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array:20 [ "pii" => "S2173572715000107" "issn" => "21735727" "doi" => "10.1016/j.medine.2013.12.004" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "659" "copyrightAnyo" => "2013" "documento" => "article" "subdocumento" => "fla" "cita" => "Med Intensiva. 2015;39:68-75" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2587 "formatos" => array:3 [ "EPUB" => 160 "HTML" => 1184 "PDF" => 1243 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173572715000065" "issn" => "21735727" "doi" => "10.1016/j.medine.2015.02.001" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "739" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "documento" => "article" "subdocumento" => "sco" "cita" => "Med Intensiva. 2015;39:97-100" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3469 "formatos" => array:3 [ "EPUB" => 160 "HTML" => 2427 "PDF" => 882 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Point of view</span>" "titulo" => "Nebulized antibiotics. An adequate option for treating ventilator-associated respiratory infection?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "97" "paginaFinal" => "100" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Antibióticos nebulizados. ¿Una opción adecuada para el tratamiento de la infección respiratoria relacionada con la ventilación mecánica?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Rodríguez, F. Barcenilla" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Rodríguez" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Barcenilla" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210569114002460" "doi" => "10.1016/j.medin.2014.10.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569114002460?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000065?idApp=WMIE" "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000065/v2_201503111049/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Regional oxygen saturation index (rSO<span class="elsevierStyleInf">2</span>) in brachioradialis and deltoid muscle. Correlation and prognosis in patients with respiratory sepsis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "68" "paginaFinal" => "75" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Rodríguez, L. Claverias, J. Marín, M. Magret, S. Rosich, M. Bodí, S. Trefler, S. Pascual, J. Gea" "autores" => array:9 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Rodríguez" "email" => array:2 [ 0 => "ahr1161@yahoo.es" 1 => "arodri.hj23.ics@gencat.cat" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Claverias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Marín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Magret" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Rosich" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "M." "apellidos" => "Bodí" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "S." "apellidos" => "Trefler" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "S." "apellidos" => "Pascual" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 8 => array:3 [ "nombre" => "J." "apellidos" => "Gea" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Critical Care Department, Hospital Universitario de Tarragona Joan XXIII, Tarragona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Institut d
tm)Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Investigación Biomèc)dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Bunyola, Mallorca, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of CEXS, UPF, Servicio de Neumología, Hospital del Mar-IMIM, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Índice de saturación tisular de oxígeno en los músculos braquiorradial y deltoides. Correlación y pronóstico en pacientes con sepsis respiratoria" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1230 "Ancho" => 2204 "Tamanyo" => 206221 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic (AUROC) curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission (baseline) and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Near-infrared spectrometry (NIRS) is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate skeletal muscle oxygenation. This technique allows the assessment of the concentration of saturated haemoglobin and myoglobin and, indirectly, provides information about the state of the microcirculation. Two different primary variables can be obtained, depending on the device used: tissue oxygenation saturation (StO<span class="elsevierStyleInf">2</span>)<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> and regional oxygen saturation index (rSO<span class="elsevierStyleInf">2</span>).<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Skeletal rSO<span class="elsevierStyleInf">2</span> muscle is equivalent to StO<span class="elsevierStyleInf">2</span>. However, StO<span class="elsevierStyleInf">2</span> is defined as a quantification of the OxyHb/HbT ratio in microcirculation of skeletal muscle as an absolute number. On the other hand, skeletal rSO<span class="elsevierStyleInf">2</span> is an index of OxyHb present within a volume of tissue; this index is expressed as the percentage of oxygenated haemoglobin relative to total haemoglobin (HbO<span class="elsevierStyleInf">2</span>/Hb sum). The INVOS 510 devices employ reflectance mode probes that have one 1.5<span class="elsevierStyleHsp" style=""></span>mm optical fibre to illuminate the tissue and two optical fibres (30<span class="elsevierStyleHsp" style=""></span>mm and 40<span class="elsevierStyleHsp" style=""></span>mm) to detect the backscattered light from the tissue. The 40<span class="elsevierStyleHsp" style=""></span>mm separated fibre measures a greater and deeper tissue volume than the 30<span class="elsevierStyleHsp" style=""></span>mm separated fibre. The difference between the spectral absorbance measured with these two probing depths is used to calculate rSO<span class="elsevierStyleInf">2</span>.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nevertheless, this technique has some difficulties, mainly due to the lack of signal processing and acquisition procedures standardization.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> The first problem arises from the difficulty of establishing a relationship between the two variables and comparing data obtained with different devices.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover, there is no standard application site for measurements. Therefore, using different muscles may derive different values of the variables. These differences might be related, to the local perfusion characteristics (including its response to different stimulus), the different metabolic functions and states, and the morphological characteristics of each muscle, among others. In this regard, Bezemer et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported that forearm StO<span class="elsevierStyleInf">2</span> is a more sensitive parameter to haemodynamic changes than thenar StO<span class="elsevierStyleInf">2</span> and that the depth at which StO<span class="elsevierStyleInf">2</span> is measured is of minor influence. On the other hand, Ikossi et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found no association between StO<span class="elsevierStyleInf">2</span> and tissue oxygen pressure (measured directly with electrodes) in deltoid muscle. Recently, our group reported that a brachioradialis rSO<span class="elsevierStyleInf">2</span> greater than 60% at ICU admission was associated with better outcome in septic patients.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The skeletal rSO<span class="elsevierStyleInf">2</span> seems to be an adequate variable for evaluating the microvascular status in patients with severe sepsis.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However, the site of application is important because there may be differences in the sensitivity of underlying muscle groups and other anatomical structures, to cardiovascular challenges. Unfortunately, there are no studies that have determined rSO<span class="elsevierStyleInf">2</span> in different application sites simultaneously using INVOS 5100 spectroscopy technology. We believe that contributing to clarifying these differences may be helpful in the management of critically ill patients, particularly in those where it is crucial to try to maintain the balance between oxygen supply and demand. The aim of this study was to investigate rSO<span class="elsevierStyleInf">2</span> behaviour in two different brachial muscles in septic patients, a proximal one (deltoid muscle, D) and a distal one (brachioradialis muscle, BR). The measurements were obtained initially at ICU admission and again 24<span class="elsevierStyleHsp" style=""></span>h after starting the treatment. The specific objectives of the study were: (1) To compare rSO<span class="elsevierStyleInf">2</span> values obtained during the evolution of the patient and simultaneously in both muscles and (2) to determine the association between those values and ICU mortality.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A prospective and observational study was conducted in a 30-bed medical•surgical ICU in a tertiary university hospital. The investigation was conducted according to the principles outlined in the Declaration of Helsinki. The study protocol was approved by the Joan XXIII University Hospital Ethics Committee (MICRO2 20/2010) and informed consent was given by each patient or their next of kin. Data obtained from rSO<span class="elsevierStyleInf">2</span> were not known by the care team and did not influence any decision about treatment or management.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">Since patients with sepsis are heterogeneous, this study included only those with severe sepsis due to community-acquired pneumonia (CAP). Inclusion criteria were: (1) severe CAP; (2) age >18 years; (3) less than 6<span class="elsevierStyleHsp" style=""></span>h between ICU admission and the first measurement; and (4) informed consent obtained from patients or relatives. Patients with morbid obesity (Corporal Mass Index >30<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) were excluded.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Severe CAP was defined as an acute lower tract infection characterized by: (1) an acute pulmonary infiltrate evident on chest radiographs and compatible with pneumonia, (2) confirmatory findings of clinical examination, (3) acquisition of the infection outside a hospital, long-term care facility or nursing home<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>, and (4) ICU admission.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Procedures</span><p id="par0040" class="elsevierStylePara elsevierViewall">Once the patient has been enrolled, demographic variables were registered and severity of illness was assessed using Acute Physiology and Chronic Health Evaluation II (APACHE II)<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>; Sequential Organ Failure Assessment score (SOFA)<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and Simplified Acute Physiology Score 3 (SAPS 3).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> measurements were taken by NIRS using system INVOS 5100 (Somanetics Corporation, Troy, MI, USA), by the technique previously described.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Briefly, NIRS is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate tissue oxygenation. The near-infrared light easily crosses biological tissues, which have a low absorption power, and is absorbed only by haemoglobin, myoglobin and oxidized cytochrome, although the contribution of these latter two to the light attenuation signal is very small. The NIRS INVOS system signal is limited to vessels that have less than 1<span class="elsevierStyleHsp" style=""></span>mm (arterioles, capillary and venules), since the elevated blood concentration of vessels with greater diameter (and greater light absorption) makes the reflection less probable. The NIRS INVOS technique uses reflectance mode probes that have one 1.5-mm optical fibre to illuminate the tissue to a depth of 4<span class="elsevierStyleHsp" style=""></span>cm, and two optical fibres to detect the backscattered light from the tissue. The signal is then transformed to a digital absolute number (rSO<span class="elsevierStyleInf">2</span>) and carried to a display unit where the values and trends are displayed on the screen. The system updates the rSO<span class="elsevierStyleInf">2</span> value at 10<span class="elsevierStyleHsp" style=""></span>s intervals.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In all patients, two probes were placed on the brachioradialis muscle, located on the anterior outside of the forearm, 1•2<span class="elsevierStyleHsp" style=""></span>cm below its insertion on the external tip of the radius in both limbs, according to the technique describe by Bezemer et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the same time, another two probes were placed on the deltoid muscle in both limbs, 1•2<span class="elsevierStyleHsp" style=""></span>cm below the acromioclavicular joint.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a stabilization period of 30•40<span class="elsevierStyleHsp" style=""></span>s, values for rSO<span class="elsevierStyleInf">2</span> were registered for each of the studied muscles. Measurements were recorded at baseline (ICU admission) and 24<span class="elsevierStyleHsp" style=""></span>h after initiating treatment. No vascular occlusion test was carried out in this study (see ‘Discussion
tm) section).</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Differences between groups were assessed using chi-square or Fisher's exact test for discrete variables and the Wilcoxon test and analysis of variance (ANOVA). The precision of the measurements obtained in both muscle groups was studied through the determination of the coefficient of variation (CV). Pearson's correlation coefficient was used to assess the association between continuous variables. The consistency of the values obtained in different application sites was assessed using the intraclass correlation coefficient (ICC), based on the model of analysis of variance for repeated measures by the process reliability. The strength of the consistency was assessed according to the value of the ICC as, very good (>0.90), good (0.71•0.90), moderate (0.51•0.70), mediocre (0.31•0.50) and null (<0.30).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In addition, Bland•Altman analysis was performed.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The predictive value of the variables for mortality was calculated using the Receiver Operator Characteristic (ROC) curve, and the Area Under the ROC (AUROC) curve was computed. The ROC graph for each variable was a plot of all the sensibility/specificity pairs resulting from different cut-off points of mortality prediction. AUROC close to 1 was considered as a “perfect” prediction model, whilst values close to 0.5 were considered poor prediction models. Difference between AUROC was obtained by Hanley and McNeil analysis.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Statistical significance was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nineteen patients with severe CAP were enrolled over an 18-month period. Baseline characteristics are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Patients were relatively young, with a moderate degree of severity of illness and an expected mortality of between 20 and 25%. The ICU crude mortality was 21.1%. No significantly differences were observed between survivors and non-survivors. Only mechanical ventilation (MV) and the presence of shock at ICU admission were variables associated with mortality.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> mean value at ICU admission was significantly higher in deltoid muscle than in brachioradialis muscle (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). This trend was also found after 24<span class="elsevierStyleHsp" style=""></span>h of treatment (65.8 [12.6] vs. 69.4 [10.5]; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.19). Measurements performed in both limbs allowed us to assess the variability due to this factor for each muscle. Thus, rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in left and right brachioradialis muscle showed a strong and significant direct correlation (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.95; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A), and an adequate consistency (ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.94; 95% CI:0.90•0.96; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). Similar results were observed for deltoid muscle <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.88; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.01 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B) and ICC of 0.88 (95% CI: 0.80•0.90; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). The precision of the measurements obtained simultaneously in both muscular groups was good, with a coefficient of variation of 3.68% and 4.38% for brachioradialis and deltoid muscles.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">On the other hand, there was a good correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> between deltoid and brachioradialis muscle (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.78; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The consistency of results was good (ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.84; 95% CI: 0.77•0.89; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001); however the Bland•Altman analysis shows a mean difference of ∧4.1 percentage points with a wide limit of agreement (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Non-survivors (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) had values of rSO<span class="elsevierStyleInf">2</span> significantly lower than survivors, both at admission and at 24<span class="elsevierStyleHsp" style=""></span>h (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). Among non-survivor patients, rSO<span class="elsevierStyleInf">2</span> values in deltoid muscle were higher than brachioradialis muscle (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). In contrast, there were no significant differences in rSO<span class="elsevierStyleInf">2</span> between the two muscle groups in survivors.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">According to our previous findings<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> a threshold of rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>60% in brachioradialis muscle on ICU admission was considered as “low” skeletal muscle oxygenation and associated with an unfavourable prognosis. No patients with brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>60% died. In contrast, 3 of 17 (17.6%) patients with deltoid rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>60% finally died. The presence of a low rSO<span class="elsevierStyleInf">2</span> (<60%) at ICU admission was associated with a mortality rate of 57% and 50% for brachioradialis and deltoid muscle respectively. Finally, even though both skeletal muscles showed consistent mortality discrimination, the AUROC curve was superior in brachioradialis values at admission and at 24<span class="elsevierStyleHsp" style=""></span>h (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>). However, this difference does not reach statistical significance neither at ICU admission (<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.81; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.41) nor at 24<span class="elsevierStyleHsp" style=""></span>h (<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.28; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.77).</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">This is the first study to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in proximal and distal skeletal muscle areas of the limbs in patients with respiratory sepsis. Sepsis causes microcirculatory derangement, characterized by decreased vascular density, a large number of non-perfused and intermittently perfused vessels and heterogeneity of capillary transit time with an increase in the proportion of fast-flow to normal-flow times.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,15,16</span></a> Our results suggest that the distal muscular area (brachioradialis muscle) might better reflect changes in tissue oxygenation than the proximal muscular area (deltoid muscle) during the first 24<span class="elsevierStyleHsp" style=""></span>h of treatment in the ICU, with no differences between the left and right sides of the body. In addition, our findings reinforce the concept that a major alteration in the muscle tissue oxygenation assessed by NIRS is associated with a worse prognosis.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Non-invasive determination of rSO<span class="elsevierStyleInf">2</span> in skeletal brachioradialis muscle has been proposed as a useful tool not only to quantify microvascular dysfunction, but also to predict the evolution of critically ill patients.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1•7,17•20</span></a> Our group has reported that values of brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>60% at ICU admission are associated with a significant increase in mortality in septic patients. These findings are confirmed in the present study, focused on patients with respiratory sepsis. Nevertheless, sepsis physiopathology brings about alterations in tissue oxygenation, due to an imbalance between supply and demand, and can be heterogeneous in different sites. Even though some factors related to oxygen supply are relatively homogeneous (i.e. concentration and saturation of haemoglobin), others like perfusion may vary depending on local factors. Factors related to oxygen muscle utilization, such as tissue bioenergetics, muscle fibre composition, enzymatic aerobic activity and myoglobin concentration might be determinant of the heterogeneity of this metabolic imbalance.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Another important finding was that skeletal rSO<span class="elsevierStyleInf">2</span> values were higher in deltoid muscle than brachioradialis muscle over the entire study period, although there was a good correlation and concordance between them; the Bland•Altman plot evidences a wide limit of agreement. This suggest that rSO<span class="elsevierStyleInf">2</span> in deltoid muscle cannot be used in place of the rSO<span class="elsevierStyleInf">2</span> brachioradialis determination. These differences might be explained by the different metabolic activity of each muscle dependent not only on the composition of the muscle fibres (oxidative or glycolytic) but also the different capillary density.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,22</span></a> To our knowledge, no studies have been published on capillary density of each muscular group. However, we know the phenotype of muscle fibres in humans for brachioradialis muscle (40% type I fibres) and deltoid (48% type I fibres).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> We could speculate that this characteristic might result in a slightly smaller number of capillaries in brachioradialis muscle compared to deltoid.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24,25</span></a> A different vascular reactivity resulting from sepsis could also be a differential element between the two muscle territories. Considering that this is one of the elements that can be inferred with NIRS technology, it is necessary to standardize measurement of the signal site. On the other hand, the prognostic value of the variables obtained depends on the sensitivity to changes they reflect. Our hypothesis was that these changes would be more marked in distal skeletal muscle territories, and our results support this idea. However, the discriminatory ability for mortality was similar for the rSO<span class="elsevierStyleInf">2</span> brachioradialis and deltoid muscle determinations. Given the difficulty of carrying out measurements in brachioradialis for anatomical or functional reasons (i.e. presence of catheters on the forearm), the deltoid might be a second option for patients with community-acquired respiratory sepsis.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Finally, another important finding of our study was the close association between early lower values of rSO<span class="elsevierStyleInf">2</span> and mortality in both muscles. These results are consistent with previous findings published by Ikossi et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> using another NIRS device (the InSpectra, Hutchinson Technology, Minneapolis, MN, USA). These authors analyzed 28 critically ill patients after a resuscitation period, and obtained mean values of tissue oxygen saturation (StO<span class="elsevierStyleInf">2</span>) in the deltoid of 63%, similar to the one observed in our patients (68% at admission). In addition, StO<span class="elsevierStyleInf">2</span> values closely correlated with tissue oxygen pressure measured directly on the muscle. Both variables were associated with development of complications. Furthermore, animal models of haemorrhagic shock<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> have shown an excellent correlation between liver and muscular (deltoid) tissue oxygenation.</p><p id="par0110" class="elsevierStylePara elsevierViewall">The fact that we obtained discriminatory prognostic values without carrying out a vascular occlusion test (VOT) is an interesting finding of the present study that confirm what our group have previously reported.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Some authors suggest that performing a VOT (interruption of the blood flow through the forearm with a pressure cuff for 3<span class="elsevierStyleHsp" style=""></span>min) is a more appropriate way to assess the functionality of vascular response.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> It is not possible to realize this test in the deltoid muscle. In addition, the main objective of the present study was to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in two muscular groups.</p><p id="par0115" class="elsevierStylePara elsevierViewall">As a collateral finding, our results suggest that there are no significant differences between the rSO<span class="elsevierStyleInf">2</span> measured in both upper limbs. Physiologically, this would be due to the predictable symmetry of the factors that influence the state of tissue oxygenation. The clinical conclusion would be that, in the absence of local factors that contraindicate it, measurements are the same for both sides of the body. It also indicates that it is not necessary to obtain the measurements in the dominant limb.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,18</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The present study has several limitations that should be addressed, even though the relevance of the findings is not challenged. First of all, there was no control group because our group had already validated rSO<span class="elsevierStyleInf">2</span> measurement techniques in healthy controls.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This study only intended to compare the performance of the measurement of the rSO<span class="elsevierStyleInf">2</span> carried out in different skeletal muscle locations. A second potential limitation is the small sample size; therefore results need to be interpreted with caution especially those related to prognosis. However, results reach significance in a homogeneous group of patients (CAP patients) which confers internal validity. Finally, we were not able to carry out either morphological or metabolic tests in the muscles studied, which could have explained the differences observed in rSO<span class="elsevierStyleInf">2</span> values. The clinical condition of septic patients makes it difficult to conduct muscular biopsies. Even so, members of our group have recently published a paper about metabolic alterations that can be found in respiratory and lower limb muscles in septic patients.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion, our results reinforce the potential usefulness of the rSO<span class="elsevierStyleInf">2</span> in the assessment of the severity and prognosis of patients with community respiratory sepsis. Brachioradialis and deltoid muscle were appropriate for measuring this variable. Furthermore, there were no significant differences between each side of the body.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Author contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Rodriguez A, Marín J, Claverias L, Magret M, Bodi M, Cos E, Rosich S, Trefler S and Pascual S have made substantial contributions to conception and design, acquisition, analysis and interpretation of data.</p><p id="par0135" class="elsevierStylePara elsevierViewall">Rodriguez A has drafted the submitted article. Marín L, Claverias L, Pascual S and Gea J have revised the manuscript critically for important intellectual content.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Rodriguez A and Gea J have provided final approval of the version to be published.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to disclose.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was partially supported by grants from the <span class="elsevierStyleGrantSponsor" id="gs0005">Fondo de Investigación Sanitaria</span> (FIS <span class="elsevierStyleGrantNumber" refid="gs0005">PI10/01538</span> and <span class="elsevierStyleGrantNumber" refid="gs0005">PI13/02011</span>) and <span class="elsevierStyleGrantSponsor" id="gs0010">Beca SEPAR</span><span class="elsevierStyleGrantNumber" refid="gs0010">264/2012</span>.</p><p id="par0155" class="elsevierStylePara elsevierViewall">The funding agency had no role in study design, in collection, analysis or interpretation of data; in writing of the manuscript; or in the decision to submit the paper for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Institute of Health Carlos III (ISC III) and SEPAR from Spain.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres452109" "titulo" => "Abstract" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Setting" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Patients" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Interventions" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec475073" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres452108" "titulo" => "Resumen" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0045" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0050" "titulo" => "Diseño" ] 2 => array:2 [ "identificador" => "abst0055" "titulo" => "Ámbito" ] 3 => array:2 [ "identificador" => "abst0060" "titulo" => "Pacientes" ] 4 => array:2 [ "identificador" => "abst0065" "titulo" => "Intervenciones" ] 5 => array:2 [ "identificador" => "abst0070" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0075" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "abst0080" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec475072" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Procedures" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Author contributions" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of interest" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "xack133948" "titulo" => "Acknowledgments" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-07-10" "fechaAceptado" => "2013-12-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec475073" "palabras" => array:5 [ 0 => "Microcirculation" 1 => "Spectroscopy" 2 => "Near-infrared" 3 => "Community-acquired pneumonia" 4 => "Tissue oxygenation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec475072" "palabras" => array:4 [ 0 => "Microcirculación" 1 => "Espectroscopia cercana al infrarrojo" 2 => "Neumonía comunitaria" 3 => "Oxigenación tisular" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare oxygen saturation index (rSO<span class="elsevierStyleInf">2</span>) obtained simultaneously in two different brachial muscles.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective and observational study.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Intensive care unit.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Critically ill patients with community-acquired pneumonia.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Two probes of NIRS device (INVOS 5100) were simultaneously placed on the brachioradialis (BR) and deltoid (D) muscles.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Variables</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> measurements were recorded at baseline (ICU admission) and at 24<span class="elsevierStyleHsp" style=""></span>h. Demographic and clinical variables were registered. Pearson's correlation coefficient was used to assess the association between continuous variables. The consistency of the correlation was assessed using the intraclass correlation coefficient (ICC) and Bland•Altman plot. The predictive value of the rSO<span class="elsevierStyleInf">2</span> for mortality was calculated by ROC curve.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Nineteen patients were included with an ICU mortality of 21.1%. The rSO<span class="elsevierStyleInf">2</span> values at baseline and at 24<span class="elsevierStyleHsp" style=""></span>h were significantly higher in D than in BR muscle. Values obtained simultaneously in both limbs showed a strong correlation and adequate consistency: BR (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.95; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001; ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.94; 95% CI: 0.90•0.96; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), D (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.88; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.01; ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.88; 95% CI: 0.80•0.90; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.001) but a wide limit of agreement. Non-survivors had rSO<span class="elsevierStyleInf">2</span> values significantly lower than survivors at all times of the study. No patient with rSO<span class="elsevierStyleInf">2</span> >60% in BR died, and only 17.6% died with an rSO<span class="elsevierStyleInf">2</span> value >60% in D. Both muscles showed consistent discriminatory power for mortality.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Both BR and D muscles were appropriate for measuring rSO<span class="elsevierStyleInf">2</span>.</p></span>" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Design" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Setting" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Patients" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Interventions" ] 5 => array:2 [ "identificador" => "abst0030" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0035" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparar el índice de saturación tisular de oxígeno (rSO<span class="elsevierStyleInf">2</span>) medido de forma simultánea en 2 diferentes músculos braquiales.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Diseño</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, observacional.</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Ámbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de Medicina Intensiva.</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Críticos con neumonía comunitaria.</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Dos sensores con tecnología NIRS (INVOS⢢ 5100) fueron ubicados de forma simultánea en los músculos braquiorradial (BR) y deltoides (D).</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Las mediciones del rSO<span class="elsevierStyleInf">2</span> se efectuaron al ingreso (basal) y a las 24<span class="elsevierStyleHsp" style=""></span>h. Se registraron los datos demográficos y clínicos. La correlación de Pearson se utilizó para estudiar la asociación entre variables continuas. La concordancia de la correlación fue valorada mediante el coeficiente de correlación intraclase (ICC) y el análisis de Bland-Altman. El valor predictivo de rSO<span class="elsevierStyleInf">2</span> para mortalidad fue calculado mediante curva ROC.</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 19 pacientes con una mortalidad de 21,1%. El valor basal y a las 24<span class="elsevierStyleHsp" style=""></span>h de rSO<span class="elsevierStyleInf">2</span> fue significativamente mayor en D respecto del BR. Los valores obtenidos de forma simultánea en ambos miembros evidenciaron una buena correlación y una adecuada concordancia: BR (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,95; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001. ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,94; IC 95%: 0,90-0,96; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), D (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,88; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,01. ICC<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,88; IC 95%: 0,80-0,90; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), así como un amplio rango de concordancia. Los fallecidos presentaron valores de rSO<span class="elsevierStyleInf">2</span> significativamente menores que los supervivientes en todos los momentos del estudio. Ningún paciente con rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>60% en BR falleció, y solo el 17,6% fallecieron con un rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>60% en D. Ambos músculos evidenciaron un buen poder de discriminación para mortalidad.</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Tanto el músculo BR como el D fueron apropiados para la medición del rSO<span class="elsevierStyleInf">2</span>.</p></span>" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "abst0045" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0050" "titulo" => "Diseño" ] 2 => array:2 [ "identificador" => "abst0055" "titulo" => "Ámbito" ] 3 => array:2 [ "identificador" => "abst0060" "titulo" => "Pacientes" ] 4 => array:2 [ "identificador" => "abst0065" "titulo" => "Intervenciones" ] 5 => array:2 [ "identificador" => "abst0070" "titulo" => "Variables" ] 6 => array:2 [ "identificador" => "abst0075" "titulo" => "Resultados" ] 7 => array:2 [ "identificador" => "abst0080" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1261 "Ancho" => 1600 "Tamanyo" => 73091 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission in brachioradialis (Br) and deltoid (D) muscles.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1135 "Ancho" => 2613 "Tamanyo" => 175497 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Correlation of rSO<span class="elsevierStyleInf">2</span> values in the brachioradialis (Br) and deltoid (D) muscle according to their side.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1284 "Ancho" => 1634 "Tamanyo" => 128778 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 900 "Ancho" => 1675 "Tamanyo" => 148191 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Comparison of regional oxygen saturation index (rSO<span class="elsevierStyleInf">2</span>) in brachioradialis and deltoid muscles (Bland•Altman analysis).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 949 "Ancho" => 2217 "Tamanyo" => 138463 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in brachioradialis and deltoid muscle according outcome.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1230 "Ancho" => 2204 "Tamanyo" => 206221 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic (AUROC) curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission (baseline) and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality.</p>" ] ] 6 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">SD: standard deviation; APACHE II: Acute Physiologic Physiology and Chronic Health Evaluation II; ICU: intensive care unit; SOFA: sequential organ failure assessment; SAPS 3: Simplified Acute Physiology Score 3; NA: not applicable.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">All patients (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>15) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age (yr), mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55.0 (16.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">52.9 (17.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">63.0 (14.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.89 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Men, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (73.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 (80.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 (50.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.27 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">APACHE II score at day-1, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.6 (6.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14.2 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21.0 (10.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SAPS 3 score at day-1, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.2 (7.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">51.1 (6.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">56.0 (9.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.24 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SOFA at day-1, mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.2 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.9 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.0 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.57 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ICU length of stay (days), mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.6 (13.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.6 (10.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20.1 (23.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Mechanical ventilation at day-1, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (47.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5 (33.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Shock at day-1, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (47.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5 (33.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ICU mortality rate, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (21.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab700669.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristic of the 19 patients with respiratory sepsis included in the study.</p>" ] ] 7 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> values are shown as mean and standard deviation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brchioradialis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brachioradialis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ICU admission \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66.9 (8.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70.3 (6.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45.7 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60.6 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">24<span class="elsevierStyleHsp" style=""></span>h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71.3 (8.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">73.5 (8.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48.4 (5.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.2 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab700670.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Skeletal regional saturation index (rSO<span class="elsevierStyleInf">2</span>) in brachioradialis and deltoid muscle at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in survivors and non-survivors.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" 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Gea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2013" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack133948" "titulo" => "Acknowledgments" "texto" => "<p id="par0160" class="elsevierStylePara elsevierViewall">The authors wish to thank Francisco Avilèc)s MD, PhD for statistical support and Phil Hoddy for revision of the English version of the manuscript.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000107?idApp=WMIE" ]
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---|---|---|---|
2024 November | 13 | 10 | 23 |
2024 October | 82 | 47 | 129 |
2024 September | 97 | 38 | 135 |
2024 August | 73 | 44 | 117 |
2024 July | 49 | 37 | 86 |
2024 June | 69 | 48 | 117 |
2024 May | 57 | 36 | 93 |
2024 April | 65 | 34 | 99 |
2024 March | 62 | 27 | 89 |
2024 February | 59 | 38 | 97 |
2024 January | 56 | 37 | 93 |
2023 December | 46 | 38 | 84 |
2023 November | 45 | 32 | 77 |
2023 October | 48 | 36 | 84 |
2023 September | 57 | 36 | 93 |
2023 August | 38 | 20 | 58 |
2023 July | 48 | 24 | 72 |
2023 June | 40 | 16 | 56 |
2023 May | 59 | 36 | 95 |
2023 April | 34 | 19 | 53 |
2023 March | 47 | 27 | 74 |
2023 February | 51 | 30 | 81 |
2023 January | 50 | 21 | 71 |
2022 December | 87 | 33 | 120 |
2022 November | 89 | 38 | 127 |
2022 October | 61 | 34 | 95 |
2022 September | 54 | 28 | 82 |
2022 August | 81 | 41 | 122 |
2022 July | 66 | 50 | 116 |
2022 June | 43 | 24 | 67 |
2022 May | 41 | 38 | 79 |
2022 April | 50 | 49 | 99 |
2022 March | 59 | 64 | 123 |
2022 February | 37 | 43 | 80 |
2022 January | 50 | 38 | 88 |
2021 December | 61 | 56 | 117 |
2021 November | 44 | 45 | 89 |
2021 October | 141 | 61 | 202 |
2021 September | 36 | 30 | 66 |
2021 August | 31 | 30 | 61 |
2021 July | 32 | 32 | 64 |
2021 June | 38 | 27 | 65 |
2021 May | 41 | 33 | 74 |
2021 April | 66 | 67 | 133 |
2021 March | 51 | 11 | 62 |
2021 February | 60 | 18 | 78 |
2021 January | 41 | 22 | 63 |
2020 December | 28 | 9 | 37 |
2020 November | 41 | 27 | 68 |
2020 October | 34 | 24 | 58 |
2020 September | 41 | 12 | 53 |
2020 August | 39 | 11 | 50 |
2020 July | 31 | 19 | 50 |
2020 June | 23 | 6 | 29 |
2020 May | 14 | 7 | 21 |
2020 April | 32 | 13 | 45 |
2020 March | 21 | 8 | 29 |
2020 February | 66 | 25 | 91 |
2020 January | 27 | 21 | 48 |
2019 December | 45 | 22 | 67 |
2019 November | 30 | 17 | 47 |
2019 October | 32 | 699 | 731 |
2019 September | 44 | 21 | 65 |
2019 August | 41 | 14 | 55 |
2019 July | 58 | 17 | 75 |
2019 June | 54 | 14 | 68 |
2019 May | 58 | 21 | 79 |
2019 April | 40 | 13 | 53 |
2019 March | 28 | 17 | 45 |
2019 February | 33 | 23 | 56 |
2019 January | 34 | 19 | 53 |
2018 December | 27 | 26 | 53 |
2018 November | 52 | 37 | 89 |
2018 October | 31 | 31 | 62 |
2018 September | 18 | 7 | 25 |
2018 August | 15 | 7 | 22 |
2018 July | 14 | 9 | 23 |
2018 June | 17 | 6 | 23 |
2018 May | 12 | 3 | 15 |
2018 April | 19 | 7 | 26 |
2018 March | 16 | 9 | 25 |
2018 February | 16 | 6 | 22 |
2018 January | 20 | 7 | 27 |
2017 December | 21 | 6 | 27 |
2017 November | 31 | 13 | 44 |
2017 October | 20 | 7 | 27 |
2017 September | 10 | 5 | 15 |
2017 August | 10 | 8 | 18 |
2017 July | 18 | 4 | 22 |
2017 June | 22 | 8 | 30 |
2017 May | 13 | 22 | 35 |
2017 April | 15 | 4 | 19 |
2017 March | 10 | 16 | 26 |
2017 February | 9 | 6 | 15 |
2017 January | 15 | 6 | 21 |
2016 December | 26 | 4 | 30 |
2016 November | 30 | 6 | 36 |
2016 October | 36 | 10 | 46 |
2016 September | 29 | 12 | 41 |
2016 August | 25 | 6 | 31 |
2016 July | 16 | 9 | 25 |