array:20 [
  "pii" => "S2173572715000107"
  "issn" => "21735727"
  "doi" => "10.1016/j.medine.2013.12.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-03-01"
  "aid" => "659"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "subdocumento" => "fla"
  "cita" => "Med Intensiva. 2015;39:68-75"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2587
    "formatos" => array:3 [
      "EPUB" => 160
      "HTML" => 1184
      "PDF" => 1243
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173572715000065"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2015.02.001"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "aid" => "739"
    "copyright" => "Elsevier España, S.L.U. and SEMICYUC"
    "documento" => "article"
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2015;39:97-100"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3469
      "formatos" => array:3 [
        "EPUB" => 160
        "HTML" => 2427
        "PDF" => 882
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Point of view</span>"
      "titulo" => "Nebulized antibiotics&#46; An adequate option for treating ventilator-associated respiratory infection&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "100"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Antibi&#243;ticos nebulizados&#46; &#191;Una opci&#243;n adecuada para el tratamiento de la infecci&#243;n respiratoria relacionada con la ventilaci&#243;n mec&#225;nica&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Rodr&#237;guez, F&#46; Barcenilla"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Rodr&#237;guez"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Barcenilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569114002460"
        "doi" => "10.1016/j.medin.2014.10.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569114002460?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000065?idApp=WMIE"
    "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000065/v2_201503111049/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
    "titulo" => "Regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscle&#46; Correlation and prognosis in patients with respiratory sepsis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "68"
        "paginaFinal" => "75"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Rodr&#237;guez, L&#46; Claverias, J&#46; Mar&#237;n, M&#46; Magret, S&#46; Rosich, M&#46; Bod&#237;, S&#46; Trefler, S&#46; Pascual, J&#46; Gea"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Rodr&#237;guez"
            "email" => array:2 [
              0 => "ahr1161&#64;yahoo&#46;es"
              1 => "arodri&#46;hj23&#46;ics&#64;gencat&#46;cat"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Claverias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Mar&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Magret"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Rosich"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Bod&#237;"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Trefler"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Pascual"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Gea"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Critical Care Department&#44; Hospital Universitario de Tarragona Joan XXIII&#44; Tarragona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institut d&#8232;tm&#41;Investigaci&#243; Sanitaria Pere Virgili&#44; Universitat Rovira i Virgili&#44; Tarragona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n Biom&#232;c&#41;dica en Red de Enfermedades Respiratorias &#40;CIBERES&#41;&#44; Instituto de Salud Carlos III&#44; Bunyola&#44; Mallorca&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of CEXS&#44; UPF&#44; Servicio de Neumolog&#237;a&#44; Hospital del Mar-IMIM&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#205;ndice de saturaci&#243;n tisular de ox&#237;geno en los m&#250;sculos braquiorradial y deltoides&#46; Correlaci&#243;n y pron&#243;stico en pacientes con sepsis respiratoria"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 1230
            "Ancho" => 2204
            "Tamanyo" => 206221
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic &#40;AUROC&#41; curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission &#40;baseline&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Near-infrared spectrometry &#40;NIRS&#41; is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate skeletal muscle oxygenation&#46; This technique allows the assessment of the concentration of saturated haemoglobin and myoglobin and&#44; indirectly&#44; provides information about the state of the microcirculation&#46; Two different primary variables can be obtained&#44; depending on the device used&#58; tissue oxygenation saturation &#40;StO<span class="elsevierStyleInf">2</span>&#41;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Skeletal rSO<span class="elsevierStyleInf">2</span> muscle is equivalent to StO<span class="elsevierStyleInf">2</span>&#46; However&#44; StO<span class="elsevierStyleInf">2</span> is defined as a quantification of the OxyHb&#47;HbT ratio in microcirculation of skeletal muscle as an absolute number&#46; On the other hand&#44; skeletal rSO<span class="elsevierStyleInf">2</span> is an index of OxyHb present within a volume of tissue&#59; this index is expressed as the percentage of oxygenated haemoglobin relative to total haemoglobin &#40;HbO<span class="elsevierStyleInf">2</span>&#47;Hb sum&#41;&#46; The INVOS 510 devices employ reflectance mode probes that have one 1&#46;5<span class="elsevierStyleHsp" style=""></span>mm optical fibre to illuminate the tissue and two optical fibres &#40;30<span class="elsevierStyleHsp" style=""></span>mm and 40<span class="elsevierStyleHsp" style=""></span>mm&#41; to detect the backscattered light from the tissue&#46; The 40<span class="elsevierStyleHsp" style=""></span>mm separated fibre measures a greater and deeper tissue volume than the 30<span class="elsevierStyleHsp" style=""></span>mm separated fibre&#46; The difference between the spectral absorbance measured with these two probing depths is used to calculate rSO<span class="elsevierStyleInf">2</span>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nevertheless&#44; this technique has some difficulties&#44; mainly due to the lack of signal processing and acquisition procedures standardization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The first problem arises from the difficulty of establishing a relationship between the two variables and comparing data obtained with different devices&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover&#44; there is no standard application site for measurements&#46; Therefore&#44; using different muscles may derive different values of the variables&#46; These differences might be related&#44; to the local perfusion characteristics &#40;including its response to different stimulus&#41;&#44; the different metabolic functions and states&#44; and the morphological characteristics of each muscle&#44; among others&#46; In this regard&#44; Bezemer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported that forearm StO<span class="elsevierStyleInf">2</span> is a more sensitive parameter to haemodynamic changes than thenar StO<span class="elsevierStyleInf">2</span> and that the depth at which StO<span class="elsevierStyleInf">2</span> is measured is of minor influence&#46; On the other hand&#44; Ikossi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found no association between StO<span class="elsevierStyleInf">2</span> and tissue oxygen pressure &#40;measured directly with electrodes&#41; in deltoid muscle&#46; Recently&#44; our group reported that a brachioradialis rSO<span class="elsevierStyleInf">2</span> greater than 60&#37; at ICU admission was associated with better outcome in septic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The skeletal rSO<span class="elsevierStyleInf">2</span> seems to be an adequate variable for evaluating the microvascular status in patients with severe sepsis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; the site of application is important because there may be differences in the sensitivity of underlying muscle groups and other anatomical structures&#44; to cardiovascular challenges&#46; Unfortunately&#44; there are no studies that have determined rSO<span class="elsevierStyleInf">2</span> in different application sites simultaneously using INVOS 5100 spectroscopy technology&#46; We believe that contributing to clarifying these differences may be helpful in the management of critically ill patients&#44; particularly in those where it is crucial to try to maintain the balance between oxygen supply and demand&#46; The aim of this study was to investigate rSO<span class="elsevierStyleInf">2</span> behaviour in two different brachial muscles in septic patients&#44; a proximal one &#40;deltoid muscle&#44; D&#41; and a distal one &#40;brachioradialis muscle&#44; BR&#41;&#46; The measurements were obtained initially at ICU admission and again 24<span class="elsevierStyleHsp" style=""></span>h after starting the treatment&#46; The specific objectives of the study were&#58; &#40;1&#41; To compare rSO<span class="elsevierStyleInf">2</span> values obtained during the evolution of the patient and simultaneously in both muscles and &#40;2&#41; to determine the association between those values and ICU mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A prospective and observational study was conducted in a 30-bed medical&#8226;surgical ICU in a tertiary university hospital&#46; The investigation was conducted according to the principles outlined in the Declaration of Helsinki&#46; The study protocol was approved by the Joan XXIII University Hospital Ethics Committee &#40;MICRO2 20&#47;2010&#41; and informed consent was given by each patient or their next of kin&#46; Data obtained from rSO<span class="elsevierStyleInf">2</span> were not known by the care team and did not influence any decision about treatment or management&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">Since patients with sepsis are heterogeneous&#44; this study included only those with severe sepsis due to community-acquired pneumonia &#40;CAP&#41;&#46; Inclusion criteria were&#58; &#40;1&#41; severe CAP&#59; &#40;2&#41; age &#62;18 years&#59; &#40;3&#41; less than 6<span class="elsevierStyleHsp" style=""></span>h between ICU admission and the first measurement&#59; and &#40;4&#41; informed consent obtained from patients or relatives&#46; Patients with morbid obesity &#40;Corporal Mass Index &#62;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Severe CAP was defined as an acute lower tract infection characterized by&#58; &#40;1&#41; an acute pulmonary infiltrate evident on chest radiographs and compatible with pneumonia&#44; &#40;2&#41; confirmatory findings of clinical examination&#44; &#40;3&#41; acquisition of the infection outside a hospital&#44; long-term care facility or nursing home<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; and &#40;4&#41; ICU admission&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Procedures</span><p id="par0040" class="elsevierStylePara elsevierViewall">Once the patient has been enrolled&#44; demographic variables were registered and severity of illness was assessed using Acute Physiology and Chronic Health Evaluation II &#40;APACHE II&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; Sequential Organ Failure Assessment score &#40;SOFA&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and Simplified Acute Physiology Score 3 &#40;SAPS 3&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> measurements were taken by NIRS using system INVOS 5100 &#40;Somanetics Corporation&#44; Troy&#44; MI&#44; USA&#41;&#44; by the technique previously described&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Briefly&#44; NIRS is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate tissue oxygenation&#46; The near-infrared light easily crosses biological tissues&#44; which have a low absorption power&#44; and is absorbed only by haemoglobin&#44; myoglobin and oxidized cytochrome&#44; although the contribution of these latter two to the light attenuation signal is very small&#46; The NIRS INVOS system signal is limited to vessels that have less than 1<span class="elsevierStyleHsp" style=""></span>mm &#40;arterioles&#44; capillary and venules&#41;&#44; since the elevated blood concentration of vessels with greater diameter &#40;and greater light absorption&#41; makes the reflection less probable&#46; The NIRS INVOS technique uses reflectance mode probes that have one 1&#46;5-mm optical fibre to illuminate the tissue to a depth of 4<span class="elsevierStyleHsp" style=""></span>cm&#44; and two optical fibres to detect the backscattered light from the tissue&#46; The signal is then transformed to a digital absolute number &#40;rSO<span class="elsevierStyleInf">2</span>&#41; and carried to a display unit where the values and trends are displayed on the screen&#46; The system updates the rSO<span class="elsevierStyleInf">2</span> value at 10<span class="elsevierStyleHsp" style=""></span>s intervals&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In all patients&#44; two probes were placed on the brachioradialis muscle&#44; located on the anterior outside of the forearm&#44; 1&#8226;2<span class="elsevierStyleHsp" style=""></span>cm below its insertion on the external tip of the radius in both limbs&#44; according to the technique describe by Bezemer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the same time&#44; another two probes were placed on the deltoid muscle in both limbs&#44; 1&#8226;2<span class="elsevierStyleHsp" style=""></span>cm below the acromioclavicular joint&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a stabilization period of 30&#8226;40<span class="elsevierStyleHsp" style=""></span>s&#44; values for rSO<span class="elsevierStyleInf">2</span> were registered for each of the studied muscles&#46; Measurements were recorded at baseline &#40;ICU admission&#41; and 24<span class="elsevierStyleHsp" style=""></span>h after initiating treatment&#46; No vascular occlusion test was carried out in this study &#40;see &#8216;Discussion&#8232;tm&#41; section&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Differences between groups were assessed using chi-square or Fisher&#39;s exact test for discrete variables and the Wilcoxon test and analysis of variance &#40;ANOVA&#41;&#46; The precision of the measurements obtained in both muscle groups was studied through the determination of the coefficient of variation &#40;CV&#41;&#46; Pearson&#39;s correlation coefficient was used to assess the association between continuous variables&#46; The consistency of the values obtained in different application sites was assessed using the intraclass correlation coefficient &#40;ICC&#41;&#44; based on the model of analysis of variance for repeated measures by the process reliability&#46; The strength of the consistency was assessed according to the value of the ICC as&#44; very good &#40;&#62;0&#46;90&#41;&#44; good &#40;0&#46;71&#8226;0&#46;90&#41;&#44; moderate &#40;0&#46;51&#8226;0&#46;70&#41;&#44; mediocre &#40;0&#46;31&#8226;0&#46;50&#41; and null &#40;&#60;0&#46;30&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In addition&#44; Bland&#8226;Altman analysis was performed&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The predictive value of the variables for mortality was calculated using the Receiver Operator Characteristic &#40;ROC&#41; curve&#44; and the Area Under the ROC &#40;AUROC&#41; curve was computed&#46; The ROC graph for each variable was a plot of all the sensibility&#47;specificity pairs resulting from different cut-off points of mortality prediction&#46; AUROC close to 1 was considered as a &#8220;perfect&#8221; prediction model&#44; whilst values close to 0&#46;5 were considered poor prediction models&#46; Difference between AUROC was obtained by Hanley and McNeil analysis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Statistical significance was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nineteen patients with severe CAP were enrolled over an 18-month period&#46; Baseline characteristics are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients were relatively young&#44; with a moderate degree of severity of illness and an expected mortality of between 20 and 25&#37;&#46; The ICU crude mortality was 21&#46;1&#37;&#46; No significantly differences were observed between survivors and non-survivors&#46; Only mechanical ventilation &#40;MV&#41; and the presence of shock at ICU admission were variables associated with mortality&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> mean value at ICU admission was significantly higher in deltoid muscle than in brachioradialis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This trend was also found after 24<span class="elsevierStyleHsp" style=""></span>h of treatment &#40;65&#46;8 &#91;12&#46;6&#93; vs&#46; 69&#46;4 &#91;10&#46;5&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;19&#41;&#46; Measurements performed in both limbs allowed us to assess the variability due to this factor for each muscle&#46; Thus&#44; rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in left and right brachioradialis muscle showed a strong and significant direct correlation &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#44; and an adequate consistency &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#59; 95&#37; CI&#58;0&#46;90&#8226;0&#46;96&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Similar results were observed for deltoid muscle <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41; and ICC of 0&#46;88 &#40;95&#37; CI&#58; 0&#46;80&#8226;0&#46;90&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; The precision of the measurements obtained simultaneously in both muscular groups was good&#44; with a coefficient of variation of 3&#46;68&#37; and 4&#46;38&#37; for brachioradialis and deltoid muscles&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">On the other hand&#44; there was a good correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> between deltoid and brachioradialis muscle &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The consistency of results was good &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;84&#59; 95&#37; CI&#58; 0&#46;77&#8226;0&#46;89&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#59; however the Bland&#8226;Altman analysis shows a mean difference of &#8743;4&#46;1 percentage points with a wide limit of agreement &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Non-survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41; had values of rSO<span class="elsevierStyleInf">2</span> significantly lower than survivors&#44; both at admission and at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; Among non-survivor patients&#44; rSO<span class="elsevierStyleInf">2</span> values in deltoid muscle were higher than brachioradialis muscle &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; In contrast&#44; there were no significant differences in rSO<span class="elsevierStyleInf">2</span> between the two muscle groups in survivors&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">According to our previous findings<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> a threshold of rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37; in brachioradialis muscle on ICU admission was considered as &#8220;low&#8221; skeletal muscle oxygenation and associated with an unfavourable prognosis&#46; No patients with brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60&#37; died&#46; In contrast&#44; 3 of 17 &#40;17&#46;6&#37;&#41; patients with deltoid rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60&#37; finally died&#46; The presence of a low rSO<span class="elsevierStyleInf">2</span> &#40;&#60;60&#37;&#41; at ICU admission was associated with a mortality rate of 57&#37; and 50&#37; for brachioradialis and deltoid muscle respectively&#46; Finally&#44; even though both skeletal muscles showed consistent mortality discrimination&#44; the AUROC curve was superior in brachioradialis values at admission and at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46; However&#44; this difference does not reach statistical significance neither at ICU admission &#40;<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;41&#41; nor at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;28&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;77&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">This is the first study to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in proximal and distal skeletal muscle areas of the limbs in patients with respiratory sepsis&#46; Sepsis causes microcirculatory derangement&#44; characterized by decreased vascular density&#44; a large number of non-perfused and intermittently perfused vessels and heterogeneity of capillary transit time with an increase in the proportion of fast-flow to normal-flow times&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;15&#44;16</span></a> Our results suggest that the distal muscular area &#40;brachioradialis muscle&#41; might better reflect changes in tissue oxygenation than the proximal muscular area &#40;deltoid muscle&#41; during the first 24<span class="elsevierStyleHsp" style=""></span>h of treatment in the ICU&#44; with no differences between the left and right sides of the body&#46; In addition&#44; our findings reinforce the concept that a major alteration in the muscle tissue oxygenation assessed by NIRS is associated with a worse prognosis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Non-invasive determination of rSO<span class="elsevierStyleInf">2</span> in skeletal brachioradialis muscle has been proposed as a useful tool not only to quantify microvascular dysfunction&#44; but also to predict the evolution of critically ill patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8226;7&#44;17&#8226;20</span></a> Our group has reported that values of brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37; at ICU admission are associated with a significant increase in mortality in septic patients&#46; These findings are confirmed in the present study&#44; focused on patients with respiratory sepsis&#46; Nevertheless&#44; sepsis physiopathology brings about alterations in tissue oxygenation&#44; due to an imbalance between supply and demand&#44; and can be heterogeneous in different sites&#46; Even though some factors related to oxygen supply are relatively homogeneous &#40;i&#46;e&#46; concentration and saturation of haemoglobin&#41;&#44; others like perfusion may vary depending on local factors&#46; Factors related to oxygen muscle utilization&#44; such as tissue bioenergetics&#44; muscle fibre composition&#44; enzymatic aerobic activity and myoglobin concentration might be determinant of the heterogeneity of this metabolic imbalance&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Another important finding was that skeletal rSO<span class="elsevierStyleInf">2</span> values were higher in deltoid muscle than brachioradialis muscle over the entire study period&#44; although there was a good correlation and concordance between them&#59; the Bland&#8226;Altman plot evidences a wide limit of agreement&#46; This suggest that rSO<span class="elsevierStyleInf">2</span> in deltoid muscle cannot be used in place of the rSO<span class="elsevierStyleInf">2</span> brachioradialis determination&#46; These differences might be explained by the different metabolic activity of each muscle dependent not only on the composition of the muscle fibres &#40;oxidative or glycolytic&#41; but also the different capillary density&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> To our knowledge&#44; no studies have been published on capillary density of each muscular group&#46; However&#44; we know the phenotype of muscle fibres in humans for brachioradialis muscle &#40;40&#37; type I fibres&#41; and deltoid &#40;48&#37; type I fibres&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> We could speculate that this characteristic might result in a slightly smaller number of capillaries in brachioradialis muscle compared to deltoid&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> A different vascular reactivity resulting from sepsis could also be a differential element between the two muscle territories&#46; Considering that this is one of the elements that can be inferred with NIRS technology&#44; it is necessary to standardize measurement of the signal site&#46; On the other hand&#44; the prognostic value of the variables obtained depends on the sensitivity to changes they reflect&#46; Our hypothesis was that these changes would be more marked in distal skeletal muscle territories&#44; and our results support this idea&#46; However&#44; the discriminatory ability for mortality was similar for the rSO<span class="elsevierStyleInf">2</span> brachioradialis and deltoid muscle determinations&#46; Given the difficulty of carrying out measurements in brachioradialis for anatomical or functional reasons &#40;i&#46;e&#46; presence of catheters on the forearm&#41;&#44; the deltoid might be a second option for patients with community-acquired respiratory sepsis&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Finally&#44; another important finding of our study was the close association between early lower values of rSO<span class="elsevierStyleInf">2</span> and mortality in both muscles&#46; These results are consistent with previous findings published by Ikossi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> using another NIRS device &#40;the InSpectra&#44; Hutchinson Technology&#44; Minneapolis&#44; MN&#44; USA&#41;&#46; These authors analyzed 28 critically ill patients after a resuscitation period&#44; and obtained mean values of tissue oxygen saturation &#40;StO<span class="elsevierStyleInf">2</span>&#41; in the deltoid of 63&#37;&#44; similar to the one observed in our patients &#40;68&#37; at admission&#41;&#46; In addition&#44; StO<span class="elsevierStyleInf">2</span> values closely correlated with tissue oxygen pressure measured directly on the muscle&#46; Both variables were associated with development of complications&#46; Furthermore&#44; animal models of haemorrhagic shock<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> have shown an excellent correlation between liver and muscular &#40;deltoid&#41; tissue oxygenation&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The fact that we obtained discriminatory prognostic values without carrying out a vascular occlusion test &#40;VOT&#41; is an interesting finding of the present study that confirm what our group have previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Some authors suggest that performing a VOT &#40;interruption of the blood flow through the forearm with a pressure cuff for 3<span class="elsevierStyleHsp" style=""></span>min&#41; is a more appropriate way to assess the functionality of vascular response&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> It is not possible to realize this test in the deltoid muscle&#46; In addition&#44; the main objective of the present study was to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in two muscular groups&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As a collateral finding&#44; our results suggest that there are no significant differences between the rSO<span class="elsevierStyleInf">2</span> measured in both upper limbs&#46; Physiologically&#44; this would be due to the predictable symmetry of the factors that influence the state of tissue oxygenation&#46; The clinical conclusion would be that&#44; in the absence of local factors that contraindicate it&#44; measurements are the same for both sides of the body&#46; It also indicates that it is not necessary to obtain the measurements in the dominant limb&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;18</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The present study has several limitations that should be addressed&#44; even though the relevance of the findings is not challenged&#46; First of all&#44; there was no control group because our group had already validated rSO<span class="elsevierStyleInf">2</span> measurement techniques in healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This study only intended to compare the performance of the measurement of the rSO<span class="elsevierStyleInf">2</span> carried out in different skeletal muscle locations&#46; A second potential limitation is the small sample size&#59; therefore results need to be interpreted with caution especially those related to prognosis&#46; However&#44; results reach significance in a homogeneous group of patients &#40;CAP patients&#41; which confers internal validity&#46; Finally&#44; we were not able to carry out either morphological or metabolic tests in the muscles studied&#44; which could have explained the differences observed in rSO<span class="elsevierStyleInf">2</span> values&#46; The clinical condition of septic patients makes it difficult to conduct muscular biopsies&#46; Even so&#44; members of our group have recently published a paper about metabolic alterations that can be found in respiratory and lower limb muscles in septic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; our results reinforce the potential usefulness of the rSO<span class="elsevierStyleInf">2</span> in the assessment of the severity and prognosis of patients with community respiratory sepsis&#46; Brachioradialis and deltoid muscle were appropriate for measuring this variable&#46; Furthermore&#44; there were no significant differences between each side of the body&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Author contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Rodriguez A&#44; Mar&#237;n J&#44; Claverias L&#44; Magret M&#44; Bodi M&#44; Cos E&#44; Rosich S&#44; Trefler S and Pascual S have made substantial contributions to conception and design&#44; acquisition&#44; analysis and interpretation of data&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Rodriguez A has drafted the submitted article&#46; Mar&#237;n L&#44; Claverias L&#44; Pascual S and Gea J have revised the manuscript critically for important intellectual content&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Rodriguez A and Gea J have provided final approval of the version to be published&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to disclose&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was partially supported by grants from the <span class="elsevierStyleGrantSponsor" id="gs0005">Fondo de Investigaci&#243;n Sanitaria</span> &#40;FIS <span class="elsevierStyleGrantNumber" refid="gs0005">PI10&#47;01538</span> and <span class="elsevierStyleGrantNumber" refid="gs0005">PI13&#47;02011</span>&#41; and <span class="elsevierStyleGrantSponsor" id="gs0010">Beca SEPAR</span><span class="elsevierStyleGrantNumber" refid="gs0010">264&#47;2012</span>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The funding agency had no role in study design&#44; in collection&#44; analysis or interpretation of data&#59; in writing of the manuscript&#59; or in the decision to submit the paper for publication&#46; The content is solely the responsibility of the authors and does not necessarily represent the official views of the Institute of Health Carlos III &#40;ISC III&#41; and SEPAR from Spain&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres452109"
          "titulo" => "Abstract"
          "secciones" => array:8 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Design"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Setting"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Patients"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Interventions"
            ]
            5 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Variables"
            ]
            6 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            7 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec475073"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres452108"
          "titulo" => "Resumen"
          "secciones" => array:8 [
            0 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Dise&#241;o"
            ]
            2 => array:2 [
              "identificador" => "abst0055"
              "titulo" => "&#193;mbito"
            ]
            3 => array:2 [
              "identificador" => "abst0060"
              "titulo" => "Pacientes"
            ]
            4 => array:2 [
              "identificador" => "abst0065"
              "titulo" => "Intervenciones"
            ]
            5 => array:2 [
              "identificador" => "abst0070"
              "titulo" => "Variables"
            ]
            6 => array:2 [
              "identificador" => "abst0075"
              "titulo" => "Resultados"
            ]
            7 => array:2 [
              "identificador" => "abst0080"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec475072"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Procedures"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Author contributions"
        ]
        9 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Funding"
        ]
        11 => array:2 [
          "identificador" => "xack133948"
          "titulo" => "Acknowledgments"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-07-10"
    "fechaAceptado" => "2013-12-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec475073"
          "palabras" => array:5 [
            0 => "Microcirculation"
            1 => "Spectroscopy"
            2 => "Near-infrared"
            3 => "Community-acquired pneumonia"
            4 => "Tissue oxygenation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec475072"
          "palabras" => array:4 [
            0 => "Microcirculaci&#243;n"
            1 => "Espectroscopia cercana al infrarrojo"
            2 => "Neumon&#237;a comunitaria"
            3 => "Oxigenaci&#243;n tisular"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; obtained simultaneously in two different brachial muscles&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective and observational study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Intensive care unit&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Critically ill patients with community-acquired pneumonia&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Two probes of NIRS device &#40;INVOS 5100&#41; were simultaneously placed on the brachioradialis &#40;BR&#41; and deltoid &#40;D&#41; muscles&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Variables</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> measurements were recorded at baseline &#40;ICU admission&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h&#46; Demographic and clinical variables were registered&#46; Pearson&#39;s correlation coefficient was used to assess the association between continuous variables&#46; The consistency of the correlation was assessed using the intraclass correlation coefficient &#40;ICC&#41; and Bland&#8226;Altman plot&#46; The predictive value of the rSO<span class="elsevierStyleInf">2</span> for mortality was calculated by ROC curve&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Nineteen patients were included with an ICU mortality of 21&#46;1&#37;&#46; The rSO<span class="elsevierStyleInf">2</span> values at baseline and at 24<span class="elsevierStyleHsp" style=""></span>h were significantly higher in D than in BR muscle&#46; Values obtained simultaneously in both limbs showed a strong correlation and adequate consistency&#58; BR &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#59; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#59; 95&#37; CI&#58; 0&#46;90&#8226;0&#46;96&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; D &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#59; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; 95&#37; CI&#58; 0&#46;80&#8226;0&#46;90&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; but a wide limit of agreement&#46; Non-survivors had rSO<span class="elsevierStyleInf">2</span> values significantly lower than survivors at all times of the study&#46; No patient with rSO<span class="elsevierStyleInf">2</span> &#62;60&#37; in BR died&#44; and only 17&#46;6&#37; died with an rSO<span class="elsevierStyleInf">2</span> value &#62;60&#37; in D&#46; Both muscles showed consistent discriminatory power for mortality&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Both BR and D muscles were appropriate for measuring rSO<span class="elsevierStyleInf">2</span>&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Design"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Setting"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Patients"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Interventions"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Variables"
          ]
          6 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          7 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparar el &#237;ndice de saturaci&#243;n tisular de ox&#237;geno &#40;rSO<span class="elsevierStyleInf">2</span>&#41; medido de forma simult&#225;nea en 2 diferentes m&#250;sculos braquiales&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; observacional&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de Medicina Intensiva&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Cr&#237;ticos con neumon&#237;a comunitaria&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Dos sensores con tecnolog&#237;a NIRS &#40;INVOS&#10402; 5100&#41; fueron ubicados de forma simult&#225;nea en los m&#250;sculos braquiorradial &#40;BR&#41; y deltoides &#40;D&#41;&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Las mediciones del rSO<span class="elsevierStyleInf">2</span> se efectuaron al ingreso &#40;basal&#41; y a las 24<span class="elsevierStyleHsp" style=""></span>h&#46; Se registraron los datos demogr&#225;ficos y cl&#237;nicos&#46; La correlaci&#243;n de Pearson se utiliz&#243; para estudiar la asociaci&#243;n entre variables continuas&#46; La concordancia de la correlaci&#243;n fue valorada mediante el coeficiente de correlaci&#243;n intraclase &#40;ICC&#41; y el an&#225;lisis de Bland-Altman&#46; El valor predictivo de rSO<span class="elsevierStyleInf">2</span> para mortalidad fue calculado mediante curva ROC&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 19 pacientes con una mortalidad de 21&#44;1&#37;&#46; El valor basal y a las 24<span class="elsevierStyleHsp" style=""></span>h de rSO<span class="elsevierStyleInf">2</span> fue significativamente mayor en D respecto del BR&#46; Los valores obtenidos de forma simult&#225;nea en ambos miembros evidenciaron una buena correlaci&#243;n y una adecuada concordancia&#58; BR &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;95&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#46; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;94&#59; IC 95&#37;&#58; 0&#44;90-0&#44;96&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; D &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;88&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;88&#59; IC 95&#37;&#58; 0&#44;80-0&#44;90&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; as&#237; como un amplio rango de concordancia&#46; Los fallecidos presentaron valores de rSO<span class="elsevierStyleInf">2</span> significativamente menores que los supervivientes en todos los momentos del estudio&#46; Ning&#250;n paciente con rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60&#37; en BR falleci&#243;&#44; y solo el 17&#44;6&#37; fallecieron con un rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60&#37; en D&#46; Ambos m&#250;sculos evidenciaron un buen poder de discriminaci&#243;n para mortalidad&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Tanto el m&#250;sculo BR como el D fueron apropiados para la medici&#243;n del rSO<span class="elsevierStyleInf">2</span>&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Dise&#241;o"
          ]
          2 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "&#193;mbito"
          ]
          3 => array:2 [
            "identificador" => "abst0060"
            "titulo" => "Pacientes"
          ]
          4 => array:2 [
            "identificador" => "abst0065"
            "titulo" => "Intervenciones"
          ]
          5 => array:2 [
            "identificador" => "abst0070"
            "titulo" => "Variables"
          ]
          6 => array:2 [
            "identificador" => "abst0075"
            "titulo" => "Resultados"
          ]
          7 => array:2 [
            "identificador" => "abst0080"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1261
            "Ancho" => 1600
            "Tamanyo" => 73091
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission in brachioradialis &#40;Br&#41; and deltoid &#40;D&#41; muscles&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1135
            "Ancho" => 2613
            "Tamanyo" => 175497
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Correlation of rSO<span class="elsevierStyleInf">2</span> values in the brachioradialis &#40;Br&#41; and deltoid &#40;D&#41; muscle according to their side&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1284
            "Ancho" => 1634
            "Tamanyo" => 128778
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 900
            "Ancho" => 1675
            "Tamanyo" => 148191
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Comparison of regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscles &#40;Bland&#8226;Altman analysis&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 949
            "Ancho" => 2217
            "Tamanyo" => 138463
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in brachioradialis and deltoid muscle according outcome&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 1230
            "Ancho" => 2204
            "Tamanyo" => 206221
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic &#40;AUROC&#41; curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission &#40;baseline&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">SD&#58; standard deviation&#59; APACHE II&#58; Acute Physiologic Physiology and Chronic Health Evaluation II&#59; ICU&#58; intensive care unit&#59; SOFA&#58; sequential organ failure assessment&#59; SAPS 3&#58; Simplified Acute Physiology Score 3&#59; NA&#58; not applicable&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">All patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;yr&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&#46;0 &#40;16&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;9 &#40;17&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#46;0 &#40;14&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Men&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;73&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;80&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">APACHE II score at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;6 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;2 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;0 &#40;10&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SAPS 3 score at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;2 &#40;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;1 &#40;6&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;0 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SOFA at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;9 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;0 &#40;3&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU length of stay &#40;days&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;6 &#40;13&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;6 &#40;10&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;1 &#40;23&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mechanical ventilation at day-1&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Shock at day-1&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU mortality rate&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab700669.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristic of the 19 patients with respiratory sepsis included in the study&#46;</p>"
        ]
      ]
      7 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> values are shown as mean and standard deviation&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brchioradialis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brachioradialis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;9 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;3 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;7 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;6 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;3 &#40;8&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;5 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#46;4 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;2 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab700670.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Skeletal regional saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscle at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in survivors and non-survivors&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognostic value of muscle StO<span class="elsevierStyleInf">2</span> in septic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Creteur"
                            1 => "T&#46; Carollo"
                            2 => "G&#46; Soldati"
                            3 => "G&#46; Buchele"
                            4 => "D&#46; De Backer"
                            5 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-007-0739-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2007"
                        "volumen" => "33"
                        "paginaInicial" => "1549"
                        "paginaFinal" => "1556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17572876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous muscle tissue oxygenation in critically injured patients&#46; A prospective observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;G&#46; Ikossi"
                            1 => "M&#46;M&#46; Knudson"
                            2 => "D&#46;J&#46; Morabito"
                            3 => "M&#46;J&#46; Cohen"
                            4 => "J&#46;J&#46; Wan"
                            5 => "L&#46; Khaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ta.0000239500.71419.58"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "780"
                        "paginaFinal" => "790"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17033541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality and regional oxygen saturation index in septic shock patients&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Rodr&#237;guez"
                            1 => "T&#46; Lisboa"
                            2 => "I&#46; Mart&#237;n-Loeches"
                            3 => "E&#46; D&#237;az"
                            4 => "S&#46; Trefler"
                            5 => "M&#46;I&#46; Restrepo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TA.0b013e318216f72c"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2011"
                        "volumen" => "70"
                        "paginaInicial" => "1145"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21610429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Near-infrared spectroscopy as an index of brain and tissue oxygenation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Murkin"
                            1 => "M&#46; Arango"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aep299"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2009"
                        "volumen" => "103"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "i3"
                        "paginaFinal" => "i13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of tissue oxygen saturation and vascular occlusion test&#58; influence of measurement sites&#44; probe sizes and deflation thresholds"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Gomez"
                            1 => "J&#46; Mesquida"
                            2 => "P&#46; Simon"
                            3 => "H&#46;K&#46; Kim"
                            4 => "J&#46;C&#46; Puyana"
                            5 => "C&#46; Ince"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S3"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy&#58; the role of probe spacing and measurement site studied in healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bezemer"
                            1 => "A&#46; Lima"
                            2 => "D&#46; Myers"
                            3 => "E&#46; Klijn"
                            4 => "M&#46; Heger"
                            5 => "P&#46;T&#46; Goedhart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bezemer"
                            1 => "J&#46;M&#46; Karemaker"
                            2 => "E&#46; Klijn"
                            3 => "D&#46; Martin"
                            4 => "K&#46; Mitchell"
                            5 => "M&#46; Grocott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibiotic prescription for community-acquired pneumonia in the intensive care unit&#58; impact of adherence to Infectious Diseases Society of America guidelines on survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Bod&#237;"
                            1 => "A&#46; Rodr&#237;guez"
                            2 => "J&#46; Sol&#232;c&#41;-Viol&#225;n"
                            3 => "M&#46;C&#46; Gilavert"
                            4 => "J&#46; Garnacho"
                            5 => "J&#46; Blanquer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/498119"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "1709"
                        "paginaFinal" => "1716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16288392"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious Diseases Society of America&#47;American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults&#46; Infectious Diseases Society of America&#59; American Thoracic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Mandell"
                            1 => "R&#46;G&#46; Wunderink"
                            2 => "A&#46; Anzueto"
                            3 => "J&#46;G&#46; Bartlett"
                            4 => "G&#46;D&#46; Campbell"
                            5 => "N&#46;C&#46; Dean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/511159"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "44"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "S27"
                        "paginaFinal" => "S72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17278083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "APACHE II&#58; a severity of disease classification system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;A&#46; Knaus"
                            1 => "E&#46;A&#46; Draper"
                            2 => "D&#46;P&#46; Wagner"
                            3 => "J&#46;E&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1985"
                        "volumen" => "13"
                        "paginaInicial" => "818"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3928249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SAPS 3&#8226;from evaluation of the patient to evaluation of the intensive care unit&#46; Part 1&#58; Objectives&#44; methods and cohort description"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;G&#46; Metnitz"
                            1 => "R&#46;P&#46; Moreno"
                            2 => "E&#46; Almeida"
                            3 => "B&#46; Jordan"
                            4 => "P&#46; Bauer"
                            5 => "R&#46;A&#46; Campos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-005-2762-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2005"
                        "volumen" => "31"
                        "paginaInicial" => "1336"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16132893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The SOFA &#40;Sepsis-related Organ Failure Assessment&#41; score to describe organ dysfunction&#47;failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Vincent"
                            1 => "R&#46; Moreno"
                            2 => "J&#46; Takala"
                            3 => "S&#46; Willatts"
                            4 => "A&#46; De Mendon&#231;a"
                            5 => "H&#46; Bruining"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "707"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8844239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The design and analysis of clinical experiments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;L&#46; Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1986"
                        "editorial" => "John Willey and Sons&#44; Inc&#46;"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The meaning and use of the area under a receiver operating characteristic &#40;ROC&#41; curve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Hanley"
                            1 => "B&#46;J&#46; McNeil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.143.1.7063747"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1982"
                        "volumen" => "143"
                        "paginaInicial" => "29"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7063747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular blood flow is altered in patients with sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; De Backer"
                            1 => "J&#46; Creteur"
                            2 => "J&#46;C&#46; Preiser"
                            3 => "M&#46;J&#46; Dubois"
                            4 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "166"
                        "paginaInicial" => "98"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091178"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a maldistribution of microvascular blood flow on capillary O<span class="elsevierStyleInf">2</span> extraction in sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;G&#46; Ellis"
                            1 => "R&#46;M&#46; Baterman"
                            2 => "M&#46;D&#46; Sharpe"
                            3 => "W&#46;J&#46; Sibbald"
                            4 => "R&#46; Gill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Heart Circ Physiol"
                        "fecha" => "2002"
                        "volumen" => "282"
                        "paginaInicial" => "H156"
                        "paginaFinal" => "H164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11748059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; De Blasi"
                            1 => "S&#46; Palmasani"
                            2 => "D&#46; Alampi"
                            3 => "M&#46; Mercieri"
                            4 => "R&#46; Romano"
                            5 => "S&#46; Collini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-005-2822-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2005"
                        "volumen" => "31"
                        "paginaInicial" => "1661"
                        "paginaFinal" => "1668"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16205889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Muscle StO<span class="elsevierStyleInf">2</span> in critically ill patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Creteur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0b013e3282fad4e1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "361"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18467900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic implications of tissue oxygen saturation in human septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Mesquida"
                            1 => "C&#46; Espinal"
                            2 => "G&#46; Gruartmoner"
                            3 => "J&#46; Masip"
                            4 => "C&#46; Sabatier"
                            5 => "F&#46; Baigorri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-012-2491-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2012"
                        "volumen" => "38"
                        "paginaInicial" => "592"
                        "paginaFinal" => "597"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22310873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of near-infrared spectroscopy in early determination of irreversible hemorrhagic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;H&#46; Taylor"
                            1 => "K&#46;E&#46; Mulier"
                            2 => "D&#46;E&#46; Myers"
                            3 => "G&#46;J&#46; Beilman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2005"
                        "volumen" => "58"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15995457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of near-infrared spectroscopy in understanding skeletal muscle physiology&#58; recent developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ferrari"
                            1 => "M&#46; Muthalib"
                            2 => "V&#46; Quaresima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Philos Trans R Soc A"
                        "fecha" => "2011"
                        "volumen" => "369"
                        "paginaInicial" => "4577"
                        "paginaFinal" => "4590"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methodological validation of the dynamic heterogeneity of muscle deoxygenation within the quadriceps during cycle exercise"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Koga"
                            1 => "D&#46;C&#46; Poole"
                            2 => "Y&#46; Fukuoka"
                            3 => "L&#46;F&#46; Ferreira"
                            4 => "N&#46; Kondo"
                            5 => "E&#46; Ohmae"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00101.2011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Regul Integr Comp Physiol"
                        "fecha" => "2011"
                        "volumen" => "301"
                        "paginaInicial" => "R534"
                        "paginaFinal" => "R541"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21632845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Data on fibre size in thirty-six human muscles&#46; An autopsy study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Polgar"
                            1 => "M&#46;A&#46; Johnson"
                            2 => "D&#46; Weightman"
                            3 => "D&#46; Appleton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1973"
                        "volumen" => "19"
                        "paginaInicial" => "307"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4716847"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Gea"
                            1 => "M&#46; Pasto"
                            2 => "M&#46;A&#46; Carmona"
                            3 => "M&#46; Orozco-Levi"
                            4 => "J&#46; Palomeque"
                            5 => "J&#46; Broquetas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "939"
                        "paginaFinal" => "945"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488330"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory diseases and muscle dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Gea"
                            1 => "C&#46; Casadevall"
                            2 => "S&#46; Pascual"
                            3 => "M&#46; Orozco-Levi"
                            4 => "E&#46; Barreiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/ers.11.81"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Respir Med"
                        "fecha" => "2012"
                        "volumen" => "6"
                        "paginaInicial" => "75"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22283581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tissue oxygen monitoring during hemorrhagic shock and resuscitation&#58; a comparison of lactated Ringer&#39;s solution&#44; hypertonic saline dextran&#44; and HBOC-201"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Knudson"
                            1 => "S&#46; Lee"
                            2 => "V&#46; Erickson"
                            3 => "D&#46; Morabito"
                            4 => "N&#46; Derugin"
                            5 => "G&#46;T&#46; Manley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TA.0000037776.28201.75"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2003"
                        "volumen" => "54"
                        "paginaInicial" => "242"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12579047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O<span class="elsevierStyleInf">2</span> saturation response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; G&#243;mez"
                            1 => "A&#46; Torres"
                            2 => "P&#46; Polanco"
                            3 => "H&#46;K&#46; Kim"
                            4 => "S&#46; Zenker"
                            5 => "J&#46;C&#46; Puyana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-008-1145-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18523754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflamaci&#243;n y estr&#232;c&#41;s oxidativo en los m&#250;sculos respiratorios y de las extremidades de pacientes con sepsis grave"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Pascual-Guardia"
                            1 => "F&#46; Arbol"
                            2 => "E&#46; S&#225;nchez"
                            3 => "C&#46; Casadevall"
                            4 => "V&#46; Merlo"
                            5 => "J&#46; Gea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack133948"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0160" class="elsevierStylePara elsevierViewall">The authors wish to thank Francisco Avil&#232;c&#41;s MD&#44; PhD for statistical support and Phil Hoddy for revision of the English version of the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000107?idApp=WMIE"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original
Regional oxygen saturation index (rSO2) in brachioradialis and deltoid muscle. Correlation and prognosis in patients with respiratory sepsis
Índice de saturación tisular de oxígeno en los músculos braquiorradial y deltoides. Correlación y pronóstico en pacientes con sepsis respiratoria
A. Rodrígueza,b,c,
Corresponding author
, L. Claveriasa, J. Marína, M. Magreta, S. Rosicha, M. Bodía,b,c, S. Treflera,b, S. Pascualc,d, J. Geac,d
a Critical Care Department, Hospital Universitario de Tarragona Joan XXIII, Tarragona, Spain
b Institut d
tm)Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain
c Centro de Investigación Biomèc)dica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Bunyola, Mallorca, Spain
d Department of CEXS, UPF, Servicio de Neumología, Hospital del Mar-IMIM, Barcelona, Spain
Read
7141
Times
was read the article
3029
Total PDF
4112
Total HTML
Share statistics
 array:20 [
  "pii" => "S2173572715000107"
  "issn" => "21735727"
  "doi" => "10.1016/j.medine.2013.12.004"
  "estado" => "S300"
  "fechaPublicacion" => "2015-03-01"
  "aid" => "659"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "subdocumento" => "fla"
  "cita" => "Med Intensiva. 2015;39:68-75"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2587
    "formatos" => array:3 [
      "EPUB" => 160
      "HTML" => 1184
      "PDF" => 1243
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173572715000065"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2015.02.001"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "aid" => "739"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "article"
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2015;39:97-100"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3469
      "formatos" => array:3 [
        "EPUB" => 160
        "HTML" => 2427
        "PDF" => 882
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Point of view</span>"
      "titulo" => "Nebulized antibiotics&#46; An adequate option for treating ventilator-associated respiratory infection&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "97"
          "paginaFinal" => "100"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Antibi&#243;ticos nebulizados&#46; &#191;Una opci&#243;n adecuada para el tratamiento de la infecci&#243;n respiratoria relacionada con la ventilaci&#243;n mec&#225;nica&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Rodr&#237;guez, F&#46; Barcenilla"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Rodr&#237;guez"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Barcenilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569114002460"
        "doi" => "10.1016/j.medin.2014.10.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569114002460?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000065?idApp=WMIE"
    "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000065/v2_201503111049/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
    "titulo" => "Regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscle&#46; Correlation and prognosis in patients with respiratory sepsis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "68"
        "paginaFinal" => "75"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Rodr&#237;guez, L&#46; Claverias, J&#46; Mar&#237;n, M&#46; Magret, S&#46; Rosich, M&#46; Bod&#237;, S&#46; Trefler, S&#46; Pascual, J&#46; Gea"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Rodr&#237;guez"
            "email" => array:2 [
              0 => "ahr1161&#64;yahoo&#46;es"
              1 => "arodri&#46;hj23&#46;ics&#64;gencat&#46;cat"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Claverias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Mar&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Magret"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Rosich"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Bod&#237;"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Trefler"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Pascual"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Gea"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Critical Care Department&#44; Hospital Universitario de Tarragona Joan XXIII&#44; Tarragona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Institut d&#8232;tm&#41;Investigaci&#243; Sanitaria Pere Virgili&#44; Universitat Rovira i Virgili&#44; Tarragona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n Biom&#232;c&#41;dica en Red de Enfermedades Respiratorias &#40;CIBERES&#41;&#44; Instituto de Salud Carlos III&#44; Bunyola&#44; Mallorca&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of CEXS&#44; UPF&#44; Servicio de Neumolog&#237;a&#44; Hospital del Mar-IMIM&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "&#205;ndice de saturaci&#243;n tisular de ox&#237;geno en los m&#250;sculos braquiorradial y deltoides&#46; Correlaci&#243;n y pron&#243;stico en pacientes con sepsis respiratoria"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 1230
            "Ancho" => 2204
            "Tamanyo" => 206221
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic &#40;AUROC&#41; curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission &#40;baseline&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Near-infrared spectrometry &#40;NIRS&#41; is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate skeletal muscle oxygenation&#46; This technique allows the assessment of the concentration of saturated haemoglobin and myoglobin and&#44; indirectly&#44; provides information about the state of the microcirculation&#46; Two different primary variables can be obtained&#44; depending on the device used&#58; tissue oxygenation saturation &#40;StO<span class="elsevierStyleInf">2</span>&#41;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Skeletal rSO<span class="elsevierStyleInf">2</span> muscle is equivalent to StO<span class="elsevierStyleInf">2</span>&#46; However&#44; StO<span class="elsevierStyleInf">2</span> is defined as a quantification of the OxyHb&#47;HbT ratio in microcirculation of skeletal muscle as an absolute number&#46; On the other hand&#44; skeletal rSO<span class="elsevierStyleInf">2</span> is an index of OxyHb present within a volume of tissue&#59; this index is expressed as the percentage of oxygenated haemoglobin relative to total haemoglobin &#40;HbO<span class="elsevierStyleInf">2</span>&#47;Hb sum&#41;&#46; The INVOS 510 devices employ reflectance mode probes that have one 1&#46;5<span class="elsevierStyleHsp" style=""></span>mm optical fibre to illuminate the tissue and two optical fibres &#40;30<span class="elsevierStyleHsp" style=""></span>mm and 40<span class="elsevierStyleHsp" style=""></span>mm&#41; to detect the backscattered light from the tissue&#46; The 40<span class="elsevierStyleHsp" style=""></span>mm separated fibre measures a greater and deeper tissue volume than the 30<span class="elsevierStyleHsp" style=""></span>mm separated fibre&#46; The difference between the spectral absorbance measured with these two probing depths is used to calculate rSO<span class="elsevierStyleInf">2</span>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nevertheless&#44; this technique has some difficulties&#44; mainly due to the lack of signal processing and acquisition procedures standardization&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The first problem arises from the difficulty of establishing a relationship between the two variables and comparing data obtained with different devices&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Moreover&#44; there is no standard application site for measurements&#46; Therefore&#44; using different muscles may derive different values of the variables&#46; These differences might be related&#44; to the local perfusion characteristics &#40;including its response to different stimulus&#41;&#44; the different metabolic functions and states&#44; and the morphological characteristics of each muscle&#44; among others&#46; In this regard&#44; Bezemer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported that forearm StO<span class="elsevierStyleInf">2</span> is a more sensitive parameter to haemodynamic changes than thenar StO<span class="elsevierStyleInf">2</span> and that the depth at which StO<span class="elsevierStyleInf">2</span> is measured is of minor influence&#46; On the other hand&#44; Ikossi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> found no association between StO<span class="elsevierStyleInf">2</span> and tissue oxygen pressure &#40;measured directly with electrodes&#41; in deltoid muscle&#46; Recently&#44; our group reported that a brachioradialis rSO<span class="elsevierStyleInf">2</span> greater than 60&#37; at ICU admission was associated with better outcome in septic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The skeletal rSO<span class="elsevierStyleInf">2</span> seems to be an adequate variable for evaluating the microvascular status in patients with severe sepsis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; the site of application is important because there may be differences in the sensitivity of underlying muscle groups and other anatomical structures&#44; to cardiovascular challenges&#46; Unfortunately&#44; there are no studies that have determined rSO<span class="elsevierStyleInf">2</span> in different application sites simultaneously using INVOS 5100 spectroscopy technology&#46; We believe that contributing to clarifying these differences may be helpful in the management of critically ill patients&#44; particularly in those where it is crucial to try to maintain the balance between oxygen supply and demand&#46; The aim of this study was to investigate rSO<span class="elsevierStyleInf">2</span> behaviour in two different brachial muscles in septic patients&#44; a proximal one &#40;deltoid muscle&#44; D&#41; and a distal one &#40;brachioradialis muscle&#44; BR&#41;&#46; The measurements were obtained initially at ICU admission and again 24<span class="elsevierStyleHsp" style=""></span>h after starting the treatment&#46; The specific objectives of the study were&#58; &#40;1&#41; To compare rSO<span class="elsevierStyleInf">2</span> values obtained during the evolution of the patient and simultaneously in both muscles and &#40;2&#41; to determine the association between those values and ICU mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">A prospective and observational study was conducted in a 30-bed medical&#8226;surgical ICU in a tertiary university hospital&#46; The investigation was conducted according to the principles outlined in the Declaration of Helsinki&#46; The study protocol was approved by the Joan XXIII University Hospital Ethics Committee &#40;MICRO2 20&#47;2010&#41; and informed consent was given by each patient or their next of kin&#46; Data obtained from rSO<span class="elsevierStyleInf">2</span> were not known by the care team and did not influence any decision about treatment or management&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">Since patients with sepsis are heterogeneous&#44; this study included only those with severe sepsis due to community-acquired pneumonia &#40;CAP&#41;&#46; Inclusion criteria were&#58; &#40;1&#41; severe CAP&#59; &#40;2&#41; age &#62;18 years&#59; &#40;3&#41; less than 6<span class="elsevierStyleHsp" style=""></span>h between ICU admission and the first measurement&#59; and &#40;4&#41; informed consent obtained from patients or relatives&#46; Patients with morbid obesity &#40;Corporal Mass Index &#62;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Severe CAP was defined as an acute lower tract infection characterized by&#58; &#40;1&#41; an acute pulmonary infiltrate evident on chest radiographs and compatible with pneumonia&#44; &#40;2&#41; confirmatory findings of clinical examination&#44; &#40;3&#41; acquisition of the infection outside a hospital&#44; long-term care facility or nursing home<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; and &#40;4&#41; ICU admission&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Procedures</span><p id="par0040" class="elsevierStylePara elsevierViewall">Once the patient has been enrolled&#44; demographic variables were registered and severity of illness was assessed using Acute Physiology and Chronic Health Evaluation II &#40;APACHE II&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#59; Sequential Organ Failure Assessment score &#40;SOFA&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and Simplified Acute Physiology Score 3 &#40;SAPS 3&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> measurements were taken by NIRS using system INVOS 5100 &#40;Somanetics Corporation&#44; Troy&#44; MI&#44; USA&#41;&#44; by the technique previously described&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Briefly&#44; NIRS is a non-invasive technique that uses the differential absorption properties of oxygenated and deoxygenated haemoglobin to evaluate tissue oxygenation&#46; The near-infrared light easily crosses biological tissues&#44; which have a low absorption power&#44; and is absorbed only by haemoglobin&#44; myoglobin and oxidized cytochrome&#44; although the contribution of these latter two to the light attenuation signal is very small&#46; The NIRS INVOS system signal is limited to vessels that have less than 1<span class="elsevierStyleHsp" style=""></span>mm &#40;arterioles&#44; capillary and venules&#41;&#44; since the elevated blood concentration of vessels with greater diameter &#40;and greater light absorption&#41; makes the reflection less probable&#46; The NIRS INVOS technique uses reflectance mode probes that have one 1&#46;5-mm optical fibre to illuminate the tissue to a depth of 4<span class="elsevierStyleHsp" style=""></span>cm&#44; and two optical fibres to detect the backscattered light from the tissue&#46; The signal is then transformed to a digital absolute number &#40;rSO<span class="elsevierStyleInf">2</span>&#41; and carried to a display unit where the values and trends are displayed on the screen&#46; The system updates the rSO<span class="elsevierStyleInf">2</span> value at 10<span class="elsevierStyleHsp" style=""></span>s intervals&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In all patients&#44; two probes were placed on the brachioradialis muscle&#44; located on the anterior outside of the forearm&#44; 1&#8226;2<span class="elsevierStyleHsp" style=""></span>cm below its insertion on the external tip of the radius in both limbs&#44; according to the technique describe by Bezemer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> At the same time&#44; another two probes were placed on the deltoid muscle in both limbs&#44; 1&#8226;2<span class="elsevierStyleHsp" style=""></span>cm below the acromioclavicular joint&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> After a stabilization period of 30&#8226;40<span class="elsevierStyleHsp" style=""></span>s&#44; values for rSO<span class="elsevierStyleInf">2</span> were registered for each of the studied muscles&#46; Measurements were recorded at baseline &#40;ICU admission&#41; and 24<span class="elsevierStyleHsp" style=""></span>h after initiating treatment&#46; No vascular occlusion test was carried out in this study &#40;see &#8216;Discussion&#8232;tm&#41; section&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Differences between groups were assessed using chi-square or Fisher&#39;s exact test for discrete variables and the Wilcoxon test and analysis of variance &#40;ANOVA&#41;&#46; The precision of the measurements obtained in both muscle groups was studied through the determination of the coefficient of variation &#40;CV&#41;&#46; Pearson&#39;s correlation coefficient was used to assess the association between continuous variables&#46; The consistency of the values obtained in different application sites was assessed using the intraclass correlation coefficient &#40;ICC&#41;&#44; based on the model of analysis of variance for repeated measures by the process reliability&#46; The strength of the consistency was assessed according to the value of the ICC as&#44; very good &#40;&#62;0&#46;90&#41;&#44; good &#40;0&#46;71&#8226;0&#46;90&#41;&#44; moderate &#40;0&#46;51&#8226;0&#46;70&#41;&#44; mediocre &#40;0&#46;31&#8226;0&#46;50&#41; and null &#40;&#60;0&#46;30&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In addition&#44; Bland&#8226;Altman analysis was performed&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The predictive value of the variables for mortality was calculated using the Receiver Operator Characteristic &#40;ROC&#41; curve&#44; and the Area Under the ROC &#40;AUROC&#41; curve was computed&#46; The ROC graph for each variable was a plot of all the sensibility&#47;specificity pairs resulting from different cut-off points of mortality prediction&#46; AUROC close to 1 was considered as a &#8220;perfect&#8221; prediction model&#44; whilst values close to 0&#46;5 were considered poor prediction models&#46; Difference between AUROC was obtained by Hanley and McNeil analysis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Statistical significance was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">Nineteen patients with severe CAP were enrolled over an 18-month period&#46; Baseline characteristics are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Patients were relatively young&#44; with a moderate degree of severity of illness and an expected mortality of between 20 and 25&#37;&#46; The ICU crude mortality was 21&#46;1&#37;&#46; No significantly differences were observed between survivors and non-survivors&#46; Only mechanical ventilation &#40;MV&#41; and the presence of shock at ICU admission were variables associated with mortality&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> mean value at ICU admission was significantly higher in deltoid muscle than in brachioradialis muscle &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This trend was also found after 24<span class="elsevierStyleHsp" style=""></span>h of treatment &#40;65&#46;8 &#91;12&#46;6&#93; vs&#46; 69&#46;4 &#91;10&#46;5&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;19&#41;&#46; Measurements performed in both limbs allowed us to assess the variability due to this factor for each muscle&#46; Thus&#44; rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in left and right brachioradialis muscle showed a strong and significant direct correlation &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#44; and an adequate consistency &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#59; 95&#37; CI&#58;0&#46;90&#8226;0&#46;96&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Similar results were observed for deltoid muscle <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41; and ICC of 0&#46;88 &#40;95&#37; CI&#58; 0&#46;80&#8226;0&#46;90&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; The precision of the measurements obtained simultaneously in both muscular groups was good&#44; with a coefficient of variation of 3&#46;68&#37; and 4&#46;38&#37; for brachioradialis and deltoid muscles&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">On the other hand&#44; there was a good correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> between deltoid and brachioradialis muscle &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;78&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The consistency of results was good &#40;ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;84&#59; 95&#37; CI&#58; 0&#46;77&#8226;0&#46;89&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#59; however the Bland&#8226;Altman analysis shows a mean difference of &#8743;4&#46;1 percentage points with a wide limit of agreement &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Non-survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41; had values of rSO<span class="elsevierStyleInf">2</span> significantly lower than survivors&#44; both at admission and at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; Among non-survivor patients&#44; rSO<span class="elsevierStyleInf">2</span> values in deltoid muscle were higher than brachioradialis muscle &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; In contrast&#44; there were no significant differences in rSO<span class="elsevierStyleInf">2</span> between the two muscle groups in survivors&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">According to our previous findings<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> a threshold of rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37; in brachioradialis muscle on ICU admission was considered as &#8220;low&#8221; skeletal muscle oxygenation and associated with an unfavourable prognosis&#46; No patients with brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60&#37; died&#46; In contrast&#44; 3 of 17 &#40;17&#46;6&#37;&#41; patients with deltoid rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60&#37; finally died&#46; The presence of a low rSO<span class="elsevierStyleInf">2</span> &#40;&#60;60&#37;&#41; at ICU admission was associated with a mortality rate of 57&#37; and 50&#37; for brachioradialis and deltoid muscle respectively&#46; Finally&#44; even though both skeletal muscles showed consistent mortality discrimination&#44; the AUROC curve was superior in brachioradialis values at admission and at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46; However&#44; this difference does not reach statistical significance neither at ICU admission &#40;<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;81&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;41&#41; nor at 24<span class="elsevierStyleHsp" style=""></span>h &#40;<span class="elsevierStyleItalic">z</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;28&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;77&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">This is the first study to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in proximal and distal skeletal muscle areas of the limbs in patients with respiratory sepsis&#46; Sepsis causes microcirculatory derangement&#44; characterized by decreased vascular density&#44; a large number of non-perfused and intermittently perfused vessels and heterogeneity of capillary transit time with an increase in the proportion of fast-flow to normal-flow times&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;15&#44;16</span></a> Our results suggest that the distal muscular area &#40;brachioradialis muscle&#41; might better reflect changes in tissue oxygenation than the proximal muscular area &#40;deltoid muscle&#41; during the first 24<span class="elsevierStyleHsp" style=""></span>h of treatment in the ICU&#44; with no differences between the left and right sides of the body&#46; In addition&#44; our findings reinforce the concept that a major alteration in the muscle tissue oxygenation assessed by NIRS is associated with a worse prognosis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Non-invasive determination of rSO<span class="elsevierStyleInf">2</span> in skeletal brachioradialis muscle has been proposed as a useful tool not only to quantify microvascular dysfunction&#44; but also to predict the evolution of critically ill patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8226;7&#44;17&#8226;20</span></a> Our group has reported that values of brachioradialis rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#37; at ICU admission are associated with a significant increase in mortality in septic patients&#46; These findings are confirmed in the present study&#44; focused on patients with respiratory sepsis&#46; Nevertheless&#44; sepsis physiopathology brings about alterations in tissue oxygenation&#44; due to an imbalance between supply and demand&#44; and can be heterogeneous in different sites&#46; Even though some factors related to oxygen supply are relatively homogeneous &#40;i&#46;e&#46; concentration and saturation of haemoglobin&#41;&#44; others like perfusion may vary depending on local factors&#46; Factors related to oxygen muscle utilization&#44; such as tissue bioenergetics&#44; muscle fibre composition&#44; enzymatic aerobic activity and myoglobin concentration might be determinant of the heterogeneity of this metabolic imbalance&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Another important finding was that skeletal rSO<span class="elsevierStyleInf">2</span> values were higher in deltoid muscle than brachioradialis muscle over the entire study period&#44; although there was a good correlation and concordance between them&#59; the Bland&#8226;Altman plot evidences a wide limit of agreement&#46; This suggest that rSO<span class="elsevierStyleInf">2</span> in deltoid muscle cannot be used in place of the rSO<span class="elsevierStyleInf">2</span> brachioradialis determination&#46; These differences might be explained by the different metabolic activity of each muscle dependent not only on the composition of the muscle fibres &#40;oxidative or glycolytic&#41; but also the different capillary density&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> To our knowledge&#44; no studies have been published on capillary density of each muscular group&#46; However&#44; we know the phenotype of muscle fibres in humans for brachioradialis muscle &#40;40&#37; type I fibres&#41; and deltoid &#40;48&#37; type I fibres&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> We could speculate that this characteristic might result in a slightly smaller number of capillaries in brachioradialis muscle compared to deltoid&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> A different vascular reactivity resulting from sepsis could also be a differential element between the two muscle territories&#46; Considering that this is one of the elements that can be inferred with NIRS technology&#44; it is necessary to standardize measurement of the signal site&#46; On the other hand&#44; the prognostic value of the variables obtained depends on the sensitivity to changes they reflect&#46; Our hypothesis was that these changes would be more marked in distal skeletal muscle territories&#44; and our results support this idea&#46; However&#44; the discriminatory ability for mortality was similar for the rSO<span class="elsevierStyleInf">2</span> brachioradialis and deltoid muscle determinations&#46; Given the difficulty of carrying out measurements in brachioradialis for anatomical or functional reasons &#40;i&#46;e&#46; presence of catheters on the forearm&#41;&#44; the deltoid might be a second option for patients with community-acquired respiratory sepsis&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Finally&#44; another important finding of our study was the close association between early lower values of rSO<span class="elsevierStyleInf">2</span> and mortality in both muscles&#46; These results are consistent with previous findings published by Ikossi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> using another NIRS device &#40;the InSpectra&#44; Hutchinson Technology&#44; Minneapolis&#44; MN&#44; USA&#41;&#46; These authors analyzed 28 critically ill patients after a resuscitation period&#44; and obtained mean values of tissue oxygen saturation &#40;StO<span class="elsevierStyleInf">2</span>&#41; in the deltoid of 63&#37;&#44; similar to the one observed in our patients &#40;68&#37; at admission&#41;&#46; In addition&#44; StO<span class="elsevierStyleInf">2</span> values closely correlated with tissue oxygen pressure measured directly on the muscle&#46; Both variables were associated with development of complications&#46; Furthermore&#44; animal models of haemorrhagic shock<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> have shown an excellent correlation between liver and muscular &#40;deltoid&#41; tissue oxygenation&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The fact that we obtained discriminatory prognostic values without carrying out a vascular occlusion test &#40;VOT&#41; is an interesting finding of the present study that confirm what our group have previously reported&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Some authors suggest that performing a VOT &#40;interruption of the blood flow through the forearm with a pressure cuff for 3<span class="elsevierStyleHsp" style=""></span>min&#41; is a more appropriate way to assess the functionality of vascular response&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> It is not possible to realize this test in the deltoid muscle&#46; In addition&#44; the main objective of the present study was to compare rSO<span class="elsevierStyleInf">2</span> values obtained simultaneously in two muscular groups&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As a collateral finding&#44; our results suggest that there are no significant differences between the rSO<span class="elsevierStyleInf">2</span> measured in both upper limbs&#46; Physiologically&#44; this would be due to the predictable symmetry of the factors that influence the state of tissue oxygenation&#46; The clinical conclusion would be that&#44; in the absence of local factors that contraindicate it&#44; measurements are the same for both sides of the body&#46; It also indicates that it is not necessary to obtain the measurements in the dominant limb&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;18</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The present study has several limitations that should be addressed&#44; even though the relevance of the findings is not challenged&#46; First of all&#44; there was no control group because our group had already validated rSO<span class="elsevierStyleInf">2</span> measurement techniques in healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This study only intended to compare the performance of the measurement of the rSO<span class="elsevierStyleInf">2</span> carried out in different skeletal muscle locations&#46; A second potential limitation is the small sample size&#59; therefore results need to be interpreted with caution especially those related to prognosis&#46; However&#44; results reach significance in a homogeneous group of patients &#40;CAP patients&#41; which confers internal validity&#46; Finally&#44; we were not able to carry out either morphological or metabolic tests in the muscles studied&#44; which could have explained the differences observed in rSO<span class="elsevierStyleInf">2</span> values&#46; The clinical condition of septic patients makes it difficult to conduct muscular biopsies&#46; Even so&#44; members of our group have recently published a paper about metabolic alterations that can be found in respiratory and lower limb muscles in septic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; our results reinforce the potential usefulness of the rSO<span class="elsevierStyleInf">2</span> in the assessment of the severity and prognosis of patients with community respiratory sepsis&#46; Brachioradialis and deltoid muscle were appropriate for measuring this variable&#46; Furthermore&#44; there were no significant differences between each side of the body&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Author contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Rodriguez A&#44; Mar&#237;n J&#44; Claverias L&#44; Magret M&#44; Bodi M&#44; Cos E&#44; Rosich S&#44; Trefler S and Pascual S have made substantial contributions to conception and design&#44; acquisition&#44; analysis and interpretation of data&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Rodriguez A has drafted the submitted article&#46; Mar&#237;n L&#44; Claverias L&#44; Pascual S and Gea J have revised the manuscript critically for important intellectual content&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Rodriguez A and Gea J have provided final approval of the version to be published&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to disclose&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was partially supported by grants from the <span class="elsevierStyleGrantSponsor" id="gs0005">Fondo de Investigaci&#243;n Sanitaria</span> &#40;FIS <span class="elsevierStyleGrantNumber" refid="gs0005">PI10&#47;01538</span> and <span class="elsevierStyleGrantNumber" refid="gs0005">PI13&#47;02011</span>&#41; and <span class="elsevierStyleGrantSponsor" id="gs0010">Beca SEPAR</span><span class="elsevierStyleGrantNumber" refid="gs0010">264&#47;2012</span>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The funding agency had no role in study design&#44; in collection&#44; analysis or interpretation of data&#59; in writing of the manuscript&#59; or in the decision to submit the paper for publication&#46; The content is solely the responsibility of the authors and does not necessarily represent the official views of the Institute of Health Carlos III &#40;ISC III&#41; and SEPAR from Spain&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres452109"
          "titulo" => "Abstract"
          "secciones" => array:8 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Design"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Setting"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Patients"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Interventions"
            ]
            5 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Variables"
            ]
            6 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            7 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec475073"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres452108"
          "titulo" => "Resumen"
          "secciones" => array:8 [
            0 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Dise&#241;o"
            ]
            2 => array:2 [
              "identificador" => "abst0055"
              "titulo" => "&#193;mbito"
            ]
            3 => array:2 [
              "identificador" => "abst0060"
              "titulo" => "Pacientes"
            ]
            4 => array:2 [
              "identificador" => "abst0065"
              "titulo" => "Intervenciones"
            ]
            5 => array:2 [
              "identificador" => "abst0070"
              "titulo" => "Variables"
            ]
            6 => array:2 [
              "identificador" => "abst0075"
              "titulo" => "Resultados"
            ]
            7 => array:2 [
              "identificador" => "abst0080"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec475072"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Procedures"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Author contributions"
        ]
        9 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Funding"
        ]
        11 => array:2 [
          "identificador" => "xack133948"
          "titulo" => "Acknowledgments"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-07-10"
    "fechaAceptado" => "2013-12-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec475073"
          "palabras" => array:5 [
            0 => "Microcirculation"
            1 => "Spectroscopy"
            2 => "Near-infrared"
            3 => "Community-acquired pneumonia"
            4 => "Tissue oxygenation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec475072"
          "palabras" => array:4 [
            0 => "Microcirculaci&#243;n"
            1 => "Espectroscopia cercana al infrarrojo"
            2 => "Neumon&#237;a comunitaria"
            3 => "Oxigenaci&#243;n tisular"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; obtained simultaneously in two different brachial muscles&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective and observational study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Intensive care unit&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Critically ill patients with community-acquired pneumonia&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Two probes of NIRS device &#40;INVOS 5100&#41; were simultaneously placed on the brachioradialis &#40;BR&#41; and deltoid &#40;D&#41; muscles&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Variables</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> measurements were recorded at baseline &#40;ICU admission&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h&#46; Demographic and clinical variables were registered&#46; Pearson&#39;s correlation coefficient was used to assess the association between continuous variables&#46; The consistency of the correlation was assessed using the intraclass correlation coefficient &#40;ICC&#41; and Bland&#8226;Altman plot&#46; The predictive value of the rSO<span class="elsevierStyleInf">2</span> for mortality was calculated by ROC curve&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Nineteen patients were included with an ICU mortality of 21&#46;1&#37;&#46; The rSO<span class="elsevierStyleInf">2</span> values at baseline and at 24<span class="elsevierStyleHsp" style=""></span>h were significantly higher in D than in BR muscle&#46; Values obtained simultaneously in both limbs showed a strong correlation and adequate consistency&#58; BR &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#59; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;94&#59; 95&#37; CI&#58; 0&#46;90&#8226;0&#46;96&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; D &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#59; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;88&#59; 95&#37; CI&#58; 0&#46;80&#8226;0&#46;90&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; but a wide limit of agreement&#46; Non-survivors had rSO<span class="elsevierStyleInf">2</span> values significantly lower than survivors at all times of the study&#46; No patient with rSO<span class="elsevierStyleInf">2</span> &#62;60&#37; in BR died&#44; and only 17&#46;6&#37; died with an rSO<span class="elsevierStyleInf">2</span> value &#62;60&#37; in D&#46; Both muscles showed consistent discriminatory power for mortality&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Both BR and D muscles were appropriate for measuring rSO<span class="elsevierStyleInf">2</span>&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Design"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Setting"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Patients"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Interventions"
          ]
          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Variables"
          ]
          6 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          7 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparar el &#237;ndice de saturaci&#243;n tisular de ox&#237;geno &#40;rSO<span class="elsevierStyleInf">2</span>&#41; medido de forma simult&#225;nea en 2 diferentes m&#250;sculos braquiales&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; observacional&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de Medicina Intensiva&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Cr&#237;ticos con neumon&#237;a comunitaria&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Dos sensores con tecnolog&#237;a NIRS &#40;INVOS&#10402; 5100&#41; fueron ubicados de forma simult&#225;nea en los m&#250;sculos braquiorradial &#40;BR&#41; y deltoides &#40;D&#41;&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Las mediciones del rSO<span class="elsevierStyleInf">2</span> se efectuaron al ingreso &#40;basal&#41; y a las 24<span class="elsevierStyleHsp" style=""></span>h&#46; Se registraron los datos demogr&#225;ficos y cl&#237;nicos&#46; La correlaci&#243;n de Pearson se utiliz&#243; para estudiar la asociaci&#243;n entre variables continuas&#46; La concordancia de la correlaci&#243;n fue valorada mediante el coeficiente de correlaci&#243;n intraclase &#40;ICC&#41; y el an&#225;lisis de Bland-Altman&#46; El valor predictivo de rSO<span class="elsevierStyleInf">2</span> para mortalidad fue calculado mediante curva ROC&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 19 pacientes con una mortalidad de 21&#44;1&#37;&#46; El valor basal y a las 24<span class="elsevierStyleHsp" style=""></span>h de rSO<span class="elsevierStyleInf">2</span> fue significativamente mayor en D respecto del BR&#46; Los valores obtenidos de forma simult&#225;nea en ambos miembros evidenciaron una buena correlaci&#243;n y una adecuada concordancia&#58; BR &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;95&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#46; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;94&#59; IC 95&#37;&#58; 0&#44;90-0&#44;96&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; D &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;88&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; ICC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;88&#59; IC 95&#37;&#58; 0&#44;80-0&#44;90&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; as&#237; como un amplio rango de concordancia&#46; Los fallecidos presentaron valores de rSO<span class="elsevierStyleInf">2</span> significativamente menores que los supervivientes en todos los momentos del estudio&#46; Ning&#250;n paciente con rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60&#37; en BR falleci&#243;&#44; y solo el 17&#44;6&#37; fallecieron con un rSO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60&#37; en D&#46; Ambos m&#250;sculos evidenciaron un buen poder de discriminaci&#243;n para mortalidad&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Tanto el m&#250;sculo BR como el D fueron apropiados para la medici&#243;n del rSO<span class="elsevierStyleInf">2</span>&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Dise&#241;o"
          ]
          2 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "&#193;mbito"
          ]
          3 => array:2 [
            "identificador" => "abst0060"
            "titulo" => "Pacientes"
          ]
          4 => array:2 [
            "identificador" => "abst0065"
            "titulo" => "Intervenciones"
          ]
          5 => array:2 [
            "identificador" => "abst0070"
            "titulo" => "Variables"
          ]
          6 => array:2 [
            "identificador" => "abst0075"
            "titulo" => "Resultados"
          ]
          7 => array:2 [
            "identificador" => "abst0080"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1261
            "Ancho" => 1600
            "Tamanyo" => 73091
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission in brachioradialis &#40;Br&#41; and deltoid &#40;D&#41; muscles&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1135
            "Ancho" => 2613
            "Tamanyo" => 175497
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Correlation of rSO<span class="elsevierStyleInf">2</span> values in the brachioradialis &#40;Br&#41; and deltoid &#40;D&#41; muscle according to their side&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1284
            "Ancho" => 1634
            "Tamanyo" => 128778
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Correlation between simultaneous grouped measurements of rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 900
            "Ancho" => 1675
            "Tamanyo" => 148191
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Comparison of regional oxygen saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscles &#40;Bland&#8226;Altman analysis&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 949
            "Ancho" => 2217
            "Tamanyo" => 138463
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">The rSO<span class="elsevierStyleInf">2</span> values at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in brachioradialis and deltoid muscle according outcome&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 1230
            "Ancho" => 2204
            "Tamanyo" => 206221
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Area Under Receiver Operating Characteristic &#40;AUROC&#41; curves for skeletal muscle rSO<span class="elsevierStyleInf">2</span> in brachioradialis and deltoid muscle at ICU admission &#40;baseline&#41; and at 24<span class="elsevierStyleHsp" style=""></span>h for mortality&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">SD&#58; standard deviation&#59; APACHE II&#58; Acute Physiologic Physiology and Chronic Health Evaluation II&#59; ICU&#58; intensive care unit&#59; SOFA&#58; sequential organ failure assessment&#59; SAPS 3&#58; Simplified Acute Physiology Score 3&#59; NA&#58; not applicable&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">All patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;yr&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&#46;0 &#40;16&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;9 &#40;17&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#46;0 &#40;14&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Men&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;73&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;80&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">APACHE II score at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;6 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;2 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;0 &#40;10&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SAPS 3 score at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;2 &#40;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;1 &#40;6&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;0 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SOFA at day-1&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;9 &#40;1&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;0 &#40;3&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU length of stay &#40;days&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;6 &#40;13&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;6 &#40;10&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;1 &#40;23&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mechanical ventilation at day-1&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Shock at day-1&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU mortality rate&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab700669.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristic of the 19 patients with respiratory sepsis included in the study&#46;</p>"
        ]
      ]
      7 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">rSO<span class="elsevierStyleInf">2</span> values are shown as mean and standard deviation&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brchioradialis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> brachioradialis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">rSO<span class="elsevierStyleInf">2</span> deltoid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ICU admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;9 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;3 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;7 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;6 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;3 &#40;8&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;5 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#46;4 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;2 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab700670.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Skeletal regional saturation index &#40;rSO<span class="elsevierStyleInf">2</span>&#41; in brachioradialis and deltoid muscle at ICU admission and at 24<span class="elsevierStyleHsp" style=""></span>h in survivors and non-survivors&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognostic value of muscle StO<span class="elsevierStyleInf">2</span> in septic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Creteur"
                            1 => "T&#46; Carollo"
                            2 => "G&#46; Soldati"
                            3 => "G&#46; Buchele"
                            4 => "D&#46; De Backer"
                            5 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-007-0739-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2007"
                        "volumen" => "33"
                        "paginaInicial" => "1549"
                        "paginaFinal" => "1556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17572876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous muscle tissue oxygenation in critically injured patients&#46; A prospective observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;G&#46; Ikossi"
                            1 => "M&#46;M&#46; Knudson"
                            2 => "D&#46;J&#46; Morabito"
                            3 => "M&#46;J&#46; Cohen"
                            4 => "J&#46;J&#46; Wan"
                            5 => "L&#46; Khaw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ta.0000239500.71419.58"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "780"
                        "paginaFinal" => "790"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17033541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality and regional oxygen saturation index in septic shock patients&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Rodr&#237;guez"
                            1 => "T&#46; Lisboa"
                            2 => "I&#46; Mart&#237;n-Loeches"
                            3 => "E&#46; D&#237;az"
                            4 => "S&#46; Trefler"
                            5 => "M&#46;I&#46; Restrepo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TA.0b013e318216f72c"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2011"
                        "volumen" => "70"
                        "paginaInicial" => "1145"
                        "paginaFinal" => "1152"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21610429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Near-infrared spectroscopy as an index of brain and tissue oxygenation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Murkin"
                            1 => "M&#46; Arango"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bja/aep299"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Anaesth"
                        "fecha" => "2009"
                        "volumen" => "103"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "i3"
                        "paginaFinal" => "i13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20007987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of tissue oxygen saturation and vascular occlusion test&#58; influence of measurement sites&#44; probe sizes and deflation thresholds"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Gomez"
                            1 => "J&#46; Mesquida"
                            2 => "P&#46; Simon"
                            3 => "H&#46;K&#46; Kim"
                            4 => "J&#46;C&#46; Puyana"
                            5 => "C&#46; Ince"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S3"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy&#58; the role of probe spacing and measurement site studied in healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bezemer"
                            1 => "A&#46; Lima"
                            2 => "D&#46; Myers"
                            3 => "E&#46; Klijn"
                            4 => "M&#46; Heger"
                            5 => "P&#46;T&#46; Goedhart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S4"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bezemer"
                            1 => "J&#46;M&#46; Karemaker"
                            2 => "E&#46; Klijn"
                            3 => "D&#46; Martin"
                            4 => "K&#46; Mitchell"
                            5 => "M&#46; Grocott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/cc8003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2009"
                        "volumen" => "13"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "S5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19951389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antibiotic prescription for community-acquired pneumonia in the intensive care unit&#58; impact of adherence to Infectious Diseases Society of America guidelines on survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Bod&#237;"
                            1 => "A&#46; Rodr&#237;guez"
                            2 => "J&#46; Sol&#232;c&#41;-Viol&#225;n"
                            3 => "M&#46;C&#46; Gilavert"
                            4 => "J&#46; Garnacho"
                            5 => "J&#46; Blanquer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/498119"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2005"
                        "volumen" => "41"
                        "paginaInicial" => "1709"
                        "paginaFinal" => "1716"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16288392"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious Diseases Society of America&#47;American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults&#46; Infectious Diseases Society of America&#59; American Thoracic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Mandell"
                            1 => "R&#46;G&#46; Wunderink"
                            2 => "A&#46; Anzueto"
                            3 => "J&#46;G&#46; Bartlett"
                            4 => "G&#46;D&#46; Campbell"
                            5 => "N&#46;C&#46; Dean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/511159"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "44"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "S27"
                        "paginaFinal" => "S72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17278083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "APACHE II&#58; a severity of disease classification system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;A&#46; Knaus"
                            1 => "E&#46;A&#46; Draper"
                            2 => "D&#46;P&#46; Wagner"
                            3 => "J&#46;E&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1985"
                        "volumen" => "13"
                        "paginaInicial" => "818"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3928249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SAPS 3&#8226;from evaluation of the patient to evaluation of the intensive care unit&#46; Part 1&#58; Objectives&#44; methods and cohort description"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;G&#46; Metnitz"
                            1 => "R&#46;P&#46; Moreno"
                            2 => "E&#46; Almeida"
                            3 => "B&#46; Jordan"
                            4 => "P&#46; Bauer"
                            5 => "R&#46;A&#46; Campos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-005-2762-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2005"
                        "volumen" => "31"
                        "paginaInicial" => "1336"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16132893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The SOFA &#40;Sepsis-related Organ Failure Assessment&#41; score to describe organ dysfunction&#47;failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Vincent"
                            1 => "R&#46; Moreno"
                            2 => "J&#46; Takala"
                            3 => "S&#46; Willatts"
                            4 => "A&#46; De Mendon&#231;a"
                            5 => "H&#46; Bruining"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "707"
                        "paginaFinal" => "710"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8844239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The design and analysis of clinical experiments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;L&#46; Fleiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1986"
                        "editorial" => "John Willey and Sons&#44; Inc&#46;"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The meaning and use of the area under a receiver operating characteristic &#40;ROC&#41; curve"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Hanley"
                            1 => "B&#46;J&#46; McNeil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.143.1.7063747"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1982"
                        "volumen" => "143"
                        "paginaInicial" => "29"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7063747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular blood flow is altered in patients with sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; De Backer"
                            1 => "J&#46; Creteur"
                            2 => "J&#46;C&#46; Preiser"
                            3 => "M&#46;J&#46; Dubois"
                            4 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "166"
                        "paginaInicial" => "98"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091178"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of a maldistribution of microvascular blood flow on capillary O<span class="elsevierStyleInf">2</span> extraction in sepsis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;G&#46; Ellis"
                            1 => "R&#46;M&#46; Baterman"
                            2 => "M&#46;D&#46; Sharpe"
                            3 => "W&#46;J&#46; Sibbald"
                            4 => "R&#46; Gill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Heart Circ Physiol"
                        "fecha" => "2002"
                        "volumen" => "282"
                        "paginaInicial" => "H156"
                        "paginaFinal" => "H164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11748059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;A&#46; De Blasi"
                            1 => "S&#46; Palmasani"
                            2 => "D&#46; Alampi"
                            3 => "M&#46; Mercieri"
                            4 => "R&#46; Romano"
                            5 => "S&#46; Collini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-005-2822-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2005"
                        "volumen" => "31"
                        "paginaInicial" => "1661"
                        "paginaFinal" => "1668"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16205889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Muscle StO<span class="elsevierStyleInf">2</span> in critically ill patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Creteur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0b013e3282fad4e1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "361"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18467900"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic implications of tissue oxygen saturation in human septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Mesquida"
                            1 => "C&#46; Espinal"
                            2 => "G&#46; Gruartmoner"
                            3 => "J&#46; Masip"
                            4 => "C&#46; Sabatier"
                            5 => "F&#46; Baigorri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-012-2491-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2012"
                        "volumen" => "38"
                        "paginaInicial" => "592"
                        "paginaFinal" => "597"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22310873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of near-infrared spectroscopy in early determination of irreversible hemorrhagic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;H&#46; Taylor"
                            1 => "K&#46;E&#46; Mulier"
                            2 => "D&#46;E&#46; Myers"
                            3 => "G&#46;J&#46; Beilman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2005"
                        "volumen" => "58"
                        "paginaInicial" => "1119"
                        "paginaFinal" => "1125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15995457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of near-infrared spectroscopy in understanding skeletal muscle physiology&#58; recent developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ferrari"
                            1 => "M&#46; Muthalib"
                            2 => "V&#46; Quaresima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Philos Trans R Soc A"
                        "fecha" => "2011"
                        "volumen" => "369"
                        "paginaInicial" => "4577"
                        "paginaFinal" => "4590"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methodological validation of the dynamic heterogeneity of muscle deoxygenation within the quadriceps during cycle exercise"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Koga"
                            1 => "D&#46;C&#46; Poole"
                            2 => "Y&#46; Fukuoka"
                            3 => "L&#46;F&#46; Ferreira"
                            4 => "N&#46; Kondo"
                            5 => "E&#46; Ohmae"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00101.2011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Regul Integr Comp Physiol"
                        "fecha" => "2011"
                        "volumen" => "301"
                        "paginaInicial" => "R534"
                        "paginaFinal" => "R541"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21632845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Data on fibre size in thirty-six human muscles&#46; An autopsy study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Polgar"
                            1 => "M&#46;A&#46; Johnson"
                            2 => "D&#46; Weightman"
                            3 => "D&#46; Appleton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "1973"
                        "volumen" => "19"
                        "paginaInicial" => "307"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4716847"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Gea"
                            1 => "M&#46; Pasto"
                            2 => "M&#46;A&#46; Carmona"
                            3 => "M&#46; Orozco-Levi"
                            4 => "J&#46; Palomeque"
                            5 => "J&#46; Broquetas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2001"
                        "volumen" => "17"
                        "paginaInicial" => "939"
                        "paginaFinal" => "945"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488330"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory diseases and muscle dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Gea"
                            1 => "C&#46; Casadevall"
                            2 => "S&#46; Pascual"
                            3 => "M&#46; Orozco-Levi"
                            4 => "E&#46; Barreiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/ers.11.81"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Respir Med"
                        "fecha" => "2012"
                        "volumen" => "6"
                        "paginaInicial" => "75"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22283581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tissue oxygen monitoring during hemorrhagic shock and resuscitation&#58; a comparison of lactated Ringer&#39;s solution&#44; hypertonic saline dextran&#44; and HBOC-201"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Knudson"
                            1 => "S&#46; Lee"
                            2 => "V&#46; Erickson"
                            3 => "D&#46; Morabito"
                            4 => "N&#46; Derugin"
                            5 => "G&#46;T&#46; Manley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TA.0000037776.28201.75"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2003"
                        "volumen" => "54"
                        "paginaInicial" => "242"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12579047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O<span class="elsevierStyleInf">2</span> saturation response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; G&#243;mez"
                            1 => "A&#46; Torres"
                            2 => "P&#46; Polanco"
                            3 => "H&#46;K&#46; Kim"
                            4 => "S&#46; Zenker"
                            5 => "J&#46;C&#46; Puyana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-008-1145-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18523754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflamaci&#243;n y estr&#232;c&#41;s oxidativo en los m&#250;sculos respiratorios y de las extremidades de pacientes con sepsis grave"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Pascual-Guardia"
                            1 => "F&#46; Arbol"
                            2 => "E&#46; S&#225;nchez"
                            3 => "C&#46; Casadevall"
                            4 => "V&#46; Merlo"
                            5 => "J&#46; Gea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack133948"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0160" class="elsevierStylePara elsevierViewall">The authors wish to thank Francisco Avil&#232;c&#41;s MD&#44; PhD for statistical support and Phil Hoddy for revision of the English version of the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000003900000002/v2_201503111049/S2173572715000107/v2_201503111049/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572715000107?idApp=WMIE"
]
Article information
ISSN: 21735727
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 13 10 23
2024 October 82 47 129
2024 September 97 38 135
2024 August 73 44 117
2024 July 49 37 86
2024 June 69 48 117
2024 May 57 36 93
2024 April 65 34 99
2024 March 62 27 89
2024 February 59 38 97
2024 January 56 37 93
2023 December 46 38 84
2023 November 45 32 77
2023 October 48 36 84
2023 September 57 36 93
2023 August 38 20 58
2023 July 48 24 72
2023 June 40 16 56
2023 May 59 36 95
2023 April 34 19 53
2023 March 47 27 74
2023 February 51 30 81
2023 January 50 21 71
2022 December 87 33 120
2022 November 89 38 127
2022 October 61 34 95
2022 September 54 28 82
2022 August 81 41 122
2022 July 66 50 116
2022 June 43 24 67
2022 May 41 38 79
2022 April 50 49 99
2022 March 59 64 123
2022 February 37 43 80
2022 January 50 38 88
2021 December 61 56 117
2021 November 44 45 89
2021 October 141 61 202
2021 September 36 30 66
2021 August 31 30 61
2021 July 32 32 64
2021 June 38 27 65
2021 May 41 33 74
2021 April 66 67 133
2021 March 51 11 62
2021 February 60 18 78
2021 January 41 22 63
2020 December 28 9 37
2020 November 41 27 68
2020 October 34 24 58
2020 September 41 12 53
2020 August 39 11 50
2020 July 31 19 50
2020 June 23 6 29
2020 May 14 7 21
2020 April 32 13 45
2020 March 21 8 29
2020 February 66 25 91
2020 January 27 21 48
2019 December 45 22 67
2019 November 30 17 47
2019 October 32 699 731
2019 September 44 21 65
2019 August 41 14 55
2019 July 58 17 75
2019 June 54 14 68
2019 May 58 21 79
2019 April 40 13 53
2019 March 28 17 45
2019 February 33 23 56
2019 January 34 19 53
2018 December 27 26 53
2018 November 52 37 89
2018 October 31 31 62
2018 September 18 7 25
2018 August 15 7 22
2018 July 14 9 23
2018 June 17 6 23
2018 May 12 3 15
2018 April 19 7 26
2018 March 16 9 25
2018 February 16 6 22
2018 January 20 7 27
2017 December 21 6 27
2017 November 31 13 44
2017 October 20 7 27
2017 September 10 5 15
2017 August 10 8 18
2017 July 18 4 22
2017 June 22 8 30
2017 May 13 22 35
2017 April 15 4 19
2017 March 10 16 26
2017 February 9 6 15
2017 January 15 6 21
2016 December 26 4 30
2016 November 30 6 36
2016 October 36 10 46
2016 September 29 12 41
2016 August 25 6 31
2016 July 16 9 25
Show all

Follow this link to access the full text of the article

Idiomas
Medicina Intensiva (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?