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which consequently reduces cerebral blood flow and eventually results in cerebral hypoxia&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Importance</span><p id="par0010" class="elsevierStylePara elsevierViewall">Benzodiazepines &#40;BZDs&#41; have been used in the urgent care of seizures for over 40 years&#44; and are considered first-line therapy for this purpose&#46; The BZDs&#44; which act on GABA<span class="elsevierStyleInf">A</span> receptors&#44; are effective in the treatment of various types of seizure&#44; have a rapid onset of action after intravenous administration&#44; excellent penetration into the central nervous system&#44; and a good safety profile&#46; Persistent generalized seizure activity increases benzodiazepine resistance&#59; therefore&#44; there is a consensus as to the need for immediate treatment of seizures&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#8211;8</span></a> Lorazepam&#44; diazepam&#44; and midazolam are the three BZDs used in this setting&#46; Lorazepam is the drug of choice due to its rapid onset of action and prolonged effect&#44; but no parenteral formulations are available in Brazil&#46; Consequently&#44; intravenous diazepam&#44; which provides seizure control in 85&#8211;90&#37; of the cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> is the first-line drug of choice for acute treatment of seizures in Brazilian practice&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Goals of this investigation</span><p id="par0015" class="elsevierStylePara elsevierViewall">When venous access is challenging or cannot be obtained&#44; the most common alternatives have been rectal diazepam and intranasal midazolam&#44; with some studies suggesting intramuscular midazolam as an additional option&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;9</span></a> The difficulty of administering BZDs rectally or intranasally and the erratic absorption provided by these routes jeopardize anticonvulsant efficacy&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;8&#44;10&#8211;13</span></a> Median time to achievement of intravenous access in children ranges from 5 to 7<span class="elsevierStyleHsp" style=""></span>min&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;11</span></a> Difficulties in obtaining venous access delay treatment and&#44; consequently&#44; increase the risk of progression to status epilepticus&#46; Thus far&#44; no consensus has been established as to the best route for administration of BZDs in the event of failed intravenous access&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The objective of this study was to compare the therapeutic efficacy of intramuscular midazolam &#40;MDZ-IM&#41; with that of intravenous diazepam &#40;DZP-IV&#41; in children admitted to the referral service of a pediatric emergency department with epileptic seizures&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Patients and methods</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Study design and setting</span><p id="par0025" class="elsevierStylePara elsevierViewall">This randomized clinical trial was carried out between August 2010 and August 2011 in a sample of children admitted to the pediatric emergency department of Santa Maria University Hospital &#40;PSPed-HUSM&#41; with epileptic seizures&#46; PSPed is a tertiary referral center in Southern Brazil&#44; staffed by dedicated pediatricians and pediatric residents&#44; which treats approximately 4000 pediatric patients per month&#46; The study was approved by the local Research Ethics Committee &#40;protocol no&#46; 0184&#46;0&#46;243&#46;000-10&#41; in accordance with the Declaration of Helsinki 1964 revised in 2008&#46; In view of the nature of the study condition and to provide the best possible benefit in this urgent setting&#44; the committee authorized immediate patient allocation and treatment without prior consent&#46; Subjects&#8217; parents or legal guardians were then notified of the trial&#44; and those who agreed to the use of patient data for research purposes were asked to provide written informed consent&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study protocol was presented by the authors and approved by the medical officers and nursing staff of the department&#44; 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&#40;a&#41; Intravenous diazepam &#40;DZP-IV&#41;&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg IV &#40;maximum dose 10<span class="elsevierStyleHsp" style=""></span>mg&#41; at a concentration of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;ml and with an application speed of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;min&#44; or &#40;b&#41; intramuscular midazolam &#40;MDZ-IM&#41;&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg IM &#40;maximum dose 15<span class="elsevierStyleHsp" style=""></span>mg&#41; at a concentration of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;ml&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were randomized in blocks of 10&#46; Five slips of paper marked &#8220;DZP-IV&#8221; and five slips marked &#8220;MDZ-IM&#8221; were placed into a brown paper envelope&#46; At the time of admission&#44; the nurse in charge of medication administration took a slip of paper from the envelope at random and administered the corresponding drug as standardized in the study protocol&#44; after adjusting the dose for weight and age&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Methods and measurements</span><p id="par0055" class="elsevierStylePara elsevierViewall">Identifying information and physiological parameters were recorded&#46; The following variables were used as outcome measures&#58; time from admission to drug administration &#40;including time required to obtain intravenous access&#41;&#44; time from drug administration to cessation of seizures&#44; and total time from admission to cessation of seizures&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Heart rate and pulse oximetry were monitored in all patients throughout treatment&#46; Vital signs were recorded on admission and every 5<span class="elsevierStyleHsp" style=""></span>min thereafter until discharge or transfer&#46; Airway suctioning&#44; supplemental oxygen&#44; or tracheal intubation were provided as necessary or when ordered by the attending physician&#46; Immediate adverse drug reactions were assessed in the first 10<span class="elsevierStyleHsp" style=""></span>min after administration of MDZ-IM or DZP-IV&#46; The emergency department where the study was performed is equipped with crash carts containing all the necessary equipment and medications for treatment of cardiorespiratory instability&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Outcomes and analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Treatment was considered successful when cessation of seizures was achieved within 5<span class="elsevierStyleHsp" style=""></span>min of administration of a single dose of study drug &#40;DZP or MDZ&#41;&#46; Requirement of a second dose of study drug or additional medications was defined as treatment failure&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Inability to obtain venous access within 4<span class="elsevierStyleHsp" style=""></span>min was defined as &#8220;failed intravenous access&#46;&#8221; This 4-min cutoff was chosen on the basis of mean time to establish intravenous access by Pediatric Emergency nursing staff during emergency care&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistical analysis&#58;</span> continuous variables were expressed as means and standard deviations&#46; Comparisons were performed using Student&#39;s <span class="elsevierStyleItalic">t</span>-test &#40;for normally distributed variables&#41; or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test &#40;in case of wide variability&#41;&#46; Categorical variables were expressed as percentages and comparisons were performed with the chi-square or Fisher&#39;s exact tests&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Results</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Characteristics of study subjects</span><p id="par0080" class="elsevierStylePara elsevierViewall">Of the 180 children admitted to the Pediatric Emergency Department at Santa Maria University Hospital &#40;Brazil&#41; with a chief complaint of convulsive seizures&#44; 144 were postictal on arrival&#46; The remaining 36 children were enrolled in the study&#46; Of these&#44; 16 were allocated to the MDZ-IM group and 20 to the DZP-IV group&#46; All children allocated to the midazolam group completed the study&#46; Of those allocated to the diazepam arm&#44; four &#40;20&#37;&#41; were excluded due to failed intravenous access&#44; and the remaining 16 completed the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The parents or guardians of all 32 children who completed the study had provided informed consent for participation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">There were no significant between-group differences in age&#44; weight&#44; sex&#44; seizure etiology&#44; vital signs&#44; or blood glucose levels on admission&#46; In both groups&#44; most children were under the age of 5 &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Main results</span><p id="par0090" class="elsevierStylePara elsevierViewall">In 14 patients in each group &#40;87&#46;5&#37;&#41;&#44; seizure activity ceased after administration of a single BZD dose&#44; which shows that both intramuscular midazolam and intravenous diazepam are effective anticonvulsants&#46; Two patients in each group &#40;12&#46;5&#37;&#41; required a second dose of study drug or additional medications for seizure control &#40;treatment failure&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In the MDZ-IM group&#44; active treatment was instituted significantly sooner than in the DZP-IV group &#40;2&#46;8 versus 7&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Total time to cessation of seizures was also significantly shorter in the MZD-IM group &#40;time between admission and seizure cessation&#44; 7&#46;3 versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; However&#44; time from drug administration to cessation of seizures was significantly shorter in the DZP-IV group &#40;3&#46;3 versus 4&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">As noted above&#44; two patients in each group &#40;12&#46;5&#37;&#41; were considered to have failed treatment due to persistence of seizures more than 5<span class="elsevierStyleHsp" style=""></span>min after BZD administration&#46; The between-group differences in time to active treatment and time to cessation of seizures held true regardless of inclusion or exclusion of the patients that failed treatment &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All children in both groups exhibited cyanosis and psychomotor agitation on admission and required supplemental oxygen by nasal cannula or non-rebreather mask&#46; One child in the DZP-IV group progressed to SE of 40-min duration&#44; requiring phenytoin for seizure control&#44; and one child had a seizure duration of 6<span class="elsevierStyleHsp" style=""></span>min&#44; requiring only an additional dose of IV diazepam&#46; In the MDZ-IM group&#44; one child had a seizure lasting 10<span class="elsevierStyleHsp" style=""></span>min&#44; requiring intravenous diazepam and phenytoin&#46; Additionally&#44; one child in the MDZ group had SE that lasted 55<span class="elsevierStyleHsp" style=""></span>min and did not respond to intravenous diazepam&#46; In this case&#44; cessation was achieved after rectal diazepam and an additional dose of intramuscular midazolam&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">One child &#40;6&#46;25&#37;&#41; in the MDZ group required intubation&#44; artificial ventilation&#44; and ICU admission due to respiratory failure on admission to the ED &#40;SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#37;&#41;&#46; Two children &#40;12&#46;5&#37;&#41; in the DZP group required intubation and ICU admission &#40;one due to severe head trauma and one due to respiratory failure with SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>80&#37;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">All children were monitored until cessation of seizures or discharge&#46; There were no significant between-group differences in vital signs &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Possible immediate adverse drug reactions &#40;those occurring within 10<span class="elsevierStyleHsp" style=""></span>min of study drug administration&#41; included hypotension in one child &#40;6&#46;3&#37;&#41; in the MDZ-IM group&#44; two children &#40;12&#46;6&#37;&#41; with hyperactivity and salivation&#44; one &#40;6&#46;3&#37;&#41; with nausea&#44; and two &#40;12&#46;6&#37;&#41; with vomiting in the DZP-IV group&#46; Nevertheless&#44; the between-group difference in adverse reactions did not reach statistical significance &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">In this randomized clinical trial where intramuscular midazolam was compared with intravenous diazepam for treatment of seizures in the pediatric emergency department&#44; the following findings were observed&#58; &#40;a&#41; in a reasonably high percentage of patients &#40;20&#37;&#41;&#44; intravenous access cannot be achieved within 5<span class="elsevierStyleHsp" style=""></span>min of admission&#59; &#40;b&#41; time from admission to active treatment and time from admission to cessation of seizures are significantly shorter with IM midazolam&#59; and&#44; the previous finding notwithstanding&#44; &#40;c&#41; time from drug administration to cessation of seizures is significantly shorter with IV diazepam instead of IM midazolam&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Current treatment protocols propose that all children with convulsive seizures of &#62;5-min duration should be managed according to established treatment algorithms for status epilepticus&#44; in view of the complications and risk of neurological damage associated with prolonged seizure activity&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The first 10<span class="elsevierStyleHsp" style=""></span>min of management should focus on protecting the airway and maintaining its patency&#44; providing supplemental oxygen&#44; measuring blood glucose&#44; obtaining intravenous access&#44; and treating the seizure with an intravenous benzodiazepine&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;8</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">One may presume that the minimum time required for a child to reach the emergency department after the onset of seizures&#44; when transported from the home by parents&#44; is 5<span class="elsevierStyleHsp" style=""></span>min&#46; Studies have estimated that at least 5&#8211;7<span class="elsevierStyleHsp" style=""></span>min are required to obtain intravenous access in pediatric patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;11</span></a> The sum of these times means at least 10&#8211;12<span class="elsevierStyleHsp" style=""></span>min will have elapsed between seizure onset and active treatment&#44; which increases the risk of complications&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">When intravenous access cannot be obtained&#44; buccal or intranasal administration of midazolam has been advocated&#44; with an effectiveness rate in the region of 60&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Despite good absorption through the mucous membranes of the mouth and nose&#44; administration of midazolam through these routes can be extraordinarily challenging due to the involuntary movements of the convulsing child and due to the presence of airway secretion&#44; which impedes proper absorption&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;13</span></a> Rectal administration of diazepam is associated with erratic absorption and poor therapeutic success rates &#40;27&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;12</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Midazolam has been used in the treatment of seizures since the 1980s&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> with a good safety profile in terms of respiratory depression and good absorption via several routes &#40;intranasal&#44; buccal&#44; rectal&#44; and intramuscular&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;15&#8211;17</span></a> A study conducted in pediatric emergency departments in Australia and New Zealand showed that&#44; when venous access could not be obtained&#44; 49&#37; of the physicians used rectal diazepam and 41&#37; used intramuscular midazolam&#44; which shows increasing preference for the intramuscular route&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">As in previous studies&#44; IV diazepam has a faster onset of action than IM midazolam after administration &#40;3&#46;3<span class="elsevierStyleHsp" style=""></span>min versus 4&#46;4<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; due to the shorter time to peak serum levels and&#44; consequently&#44; earlier achievement of therapeutic levels in the CNS&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;11&#44;19</span></a> Nevertheless&#44; actual time to cessation of seizures &#40;i&#46;e&#46; time from admission to the emergency department to cessation of seizure activity&#41; was significantly shorter in the IM midazolam group &#40;7&#46;3<span class="elsevierStyleHsp" style=""></span>min versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; which corroborates the observations of a similar trial&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">These results suggest that&#44; when treating children with convulsive seizures in whom venous access is expected to be difficult or unlikely&#44; IM administration of midazolam is safe&#44; effective&#44; and perhaps superior to intravenous diazepam&#46; It bears stressing that seizure duration is directly associated with the speed of benzodiazepine administration&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Similar findings have been reported in the treatment of behavioral disturbances in adult patients &#40;where intravenous access is also challenging&#41;&#44; where IM administration was superior to IV sedation in terms of time to cessation of psychomotor agitation &#40;21<span class="elsevierStyleHsp" style=""></span>min versus 30<span class="elsevierStyleHsp" style=""></span>min&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Therefore&#44; even though BZDs act more rapidly when administered by the intravenous route&#44; early intramuscular administration of midazolam provides superior therapeutic efficacy&#44; due to faster administration as well as due to the excellent absorption of midazolam by this route&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Failed intravenous access is widely recognized as a hindrance to implementation of urgent care protocols in the pediatric emergency department&#46; It is estimated that 2&#46;5&#8211;16<span class="elsevierStyleHsp" style=""></span>min are required to obtain peripheral venous access in adults&#44; with a failure rate of 10&#8211;40&#37;&#46; In children&#44; this rate ranges from 14&#37; to 70&#37;&#44; with failure being most common in infants&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;22&#8211;24</span></a> Venous access could not be obtained in 20&#37; of the 20 children randomized to the DZP-IV arm of this study&#44; which provides further evidence of the importance of intramuscular administration of anticonvulsants in this setting&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Adverse effects were more frequent in the diazepam group&#44; as expected in view of previous comparisons with midazolam and lorazepam&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;19</span></a> although the difference did not reach statistical significance&#46; The adverse effects of BZDs are usually dose-dependent and associated with repeated administration&#44; and manifest most commonly as reduced oxygen saturation and central hypoventilation&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> These findings are rapidly reversed with administration of supplemental oxygen&#44; airway suctioning and positional maneuvers and&#44; in a minority of cases&#44; bag-valve-mask ventilation&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The etiology of seizures varies according to age and geographical region&#46; However&#44; most studies report that approximately one-third of children admitted to an emergency department with convulsions are having a febrile seizure&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#8211;27</span></a> as was the case in the present study&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">One limitation of this study is that the sample size precludes any conclusions about adverse effects and drug safety&#44; which would require a larger population&#46; Furthermore&#44; due to the design and nature of the study&#44; personnel in charge of administering drugs were not blinded to allocation&#44; which may have introduced bias&#46; Despite this limitation&#44; the times to seizure cessation obtained in this study were highly favorable&#44; especially in view of the study setting &#40;the dedicated pediatric emergency department of a large&#44; university-affiliated tertiary care center&#41;&#46; One may presume that at smaller hospitals&#44; where staff might have less skill or experience obtaining intravenous access in children&#44; the difference would be even more significant&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Another limitation of the present study is the fact that&#44; although the cause of seizure could be initially identified at the emergency room in most patients&#44; this initial identification does reach a 100&#37; level of certainty&#46; Therefore&#44; emergency room professionals may have failed to identify&#44; at first&#44; a child with an underlying neurological disease leading to unresponsiveness to seizure treatment&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The results of the study suggest that intramuscular midazolam significantly shortens seizure duration in children as compared with intravenous diazepam&#46; Therefore&#44; intramuscular midazolam is a good alternative to intravenous diazepam&#44; in view of its anticonvulsant efficacy and speed and ease of administration in the pediatric emergency care setting&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Authors&#8217; contribution</span><p id="par0195" class="elsevierStylePara elsevierViewall">All authors took part in data collection and analysis&#44; literature review&#44; and drafting of the manuscript&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Aim</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare the therapeutic efficacy of intramuscular midazolam &#40;MDZ-IM&#41; with that of intravenous diazepam &#40;DZP-IV&#41; for seizures in children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Randomized clinical trial&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pediatric emergency department&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients&#58; Children aged 2 months to 14 years admitted to the study facility with seizures&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Intervention</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patients were randomized to receive DZP-IV or MDZ-IM&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Main measurements</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Groups were compared with respect to time to treatment start &#40;min&#41;&#44; time from drug administration to seizure cessation &#40;min&#41;&#44; time to seizure cessation &#40;min&#41;&#44; and rate of treatment failure&#46; Treatment was considered successful when seizure cessation was achieved within 5<span class="elsevierStyleHsp" style=""></span>min of drug administration&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Overall&#44; 32 children &#40;16 per group&#41; completed the study&#46; Intravenous access could not be obtained within 5<span class="elsevierStyleHsp" style=""></span>min in four patients &#40;25&#37;&#41; in the DZP-IV group&#46; Time from admission to active treatment and time to seizure cessation was shorter in the MDZ-IM group &#40;2&#46;8 versus 7&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001 and 7&#46;3 versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#44; respectively&#41;&#46; In two children per group &#40;12&#46;5&#37;&#41;&#44; seizures continued after 10<span class="elsevierStyleHsp" style=""></span>min of treatment&#44; and additional medications were required&#46; There were no between-group differences in physiological parameters or adverse events &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;171&#41;&#59; one child &#40;6&#46;3&#37;&#41; developed hypotension in the MDZ-IM group and five &#40;31&#37;&#41; developed hyperactivity or vomiting in the DZP-IV group&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Given its efficacy and ease and speed of administration&#44; intramuscular midazolam is an excellent option for treatment of childhood seizures&#44; enabling earlier treatment and shortening overall seizure duration&#46; There were no differences in complications when applying MDZ-IM or DZP-IV&#46;</p></span>"
        "secciones" => array:7 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Aim"
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            "titulo" => "Design"
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            "identificador" => "abst0015"
            "titulo" => "Setting"
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            "titulo" => "Intervention"
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            "titulo" => "Main measurements"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparar la eficacia de midazolam intramuscular &#40;MDZ-IM&#41; con la de diazepam intravenoso &#40;DZP-IV&#41; para convulsiones en ni&#241;os&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Ensayo cl&#237;nico aleatorizado&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de Urgencias Pedi&#225;tricas&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Ni&#241;os de entre 2 meses y 14 a&#241;os internados con convulsiones&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Intervenci&#243;n</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron aleatorizados para recibir DZP-IV o MDZ-IM&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Mediciones principales</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Tiempo hasta el inicio del tratamiento &#40;minutos&#41;&#44; tiempo entre la administraci&#243;n del medicamento y el cese de la convulsi&#243;n &#40;minutos&#41;&#44; tiempo hasta el cese de la convulsi&#243;n &#40;minutos&#41;&#44; y tasa de fallo del tratamiento&#46; El tratamiento fue considerado exitoso cuando las convulsiones cesaron en los 5<span class="elsevierStyleHsp" style=""></span>min tras la administraci&#243;n del medicamento&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Completaron el estudio 32 ni&#241;os &#40;16 por grupo&#41;&#46; No fue posible obtener acceso intravenoso en 4 pacientes &#40;25&#37;&#41; del grupo DZP-IV&#46; El tiempo entre la internaci&#243;n y el tratamiento fue menor en el grupo MDZ-IM &#40;2&#44;8 vs&#46; 7&#44;4 min&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; as&#237; como el tiempo hasta el cese de la convulsi&#243;n &#40;7&#44;3 vs&#46; 10&#44;6 min&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#46; En 2 ni&#241;os de cada grupo &#40;12&#44;5&#37;&#41;&#44; las convulsiones continuaron despu&#233;s de 10<span class="elsevierStyleHsp" style=""></span>min de tratamiento&#46; No hubo diferencias entre los grupos en los par&#225;metros fisiol&#243;gicos o eventos adversos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;171&#41;&#59; un ni&#241;o &#40;6&#44;3&#37;&#41; del grupo MDZ-IM present&#243; hipotensi&#243;n&#44; y 5 del grupo DZP-IV &#40;31&#37;&#41; presentaron hiperactividad o v&#243;mitos&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusi&#243;n</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Dada su eficacia&#44; facilidad y velocidad de administraci&#243;n&#44; MDZ-IM es una excelente opci&#243;n para el tratamiento de convulsiones infantiles&#44; posibilitando un tratamiento precoz y reduciendo la duraci&#243;n de la convulsi&#243;n&#46; No hubo diferencias en las complicaciones al aplicar MDZ-IM o DZP-IV&#46;</p></span>"
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            "identificador" => "abst0065"
            "titulo" => "Mediciones principales"
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            "identificador" => "abst0070"
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            "identificador" => "abst0075"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Work center&#58; Pediatric Emergency Department&#44; Hospital Universit&#225;rio de Santa Maria Universidade Federal de Santa Maria &#40;UFSM&#41;&#44; Av&#46; Roraima&#44; Pr&#233;dio 22&#44; Campus&#44; Bairro Camobi&#44; Zip Code&#58; 97105-900 &#8211; Santa Maria&#44; RS&#44; Brazil&#46;</p>"
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        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "mostrarDisplay" => false
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          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Vital signs &#40;systolic and diastolic blood pressure&#44; heart rate&#44; respiratory rate&#41; of children in the IM midazolam and IV diazepam groups&#44; at 5<span class="elsevierStyleHsp" style=""></span>min&#44; 10<span class="elsevierStyleHsp" style=""></span>min&#44; and discharge or transfer&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intramuscular midazolam&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intravenous diazepam&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;months&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>53&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Median &#40;range&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Weight &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;000<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;5 &#40;8&#46;1&#8211;19&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Male sex&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">99&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;670<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">149&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>31&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;289<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Respiratory rate &#40;bpm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;985<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Oxygen saturation &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;7&nbsp;\t\t\t\t\t\t\n
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                        0 => array:2 [
                          "etal" => false
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                      "titulo" => "Benzodiazepines for prolonged seizures"
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                    0 => array:2 [
                      "doi" => "10.1136/adc.2009.176321"
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                        "tituloSerie" => "Arch Dis Child Educ Pract Ed"
                        "fecha" => "2010"
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                        "tituloSerie" => "J Pediatr &#40;Rio J&#41;"
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                        "volumen" => "75"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "S197"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Paediatr Child Health"
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Original
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: A randomized clinical trial
Midazolam intramuscular frente a diazepam intravenoso para el tratamiento de convulsiones en el Servicio de Urgencias Pediátricas: ensayo clínico aleatorizado
J.L. Portelaa,b, P.C.R. Garciac,d,
Corresponding author
, J.P. Pivae,f, A. Barcelosb,g, F. Brunoc,d, R. Brancoh, R.C. Taskeri,j
a Pediatric Emergency Department, Hospital Universitário de Santa Maria, Universidade Federal de Santa Maria (UFSM), Av. Roraima, Prédio 22, Campus, Bairro Camobi, Zip Code: 97105 900, Santa Maria, RS, Brazil
b School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
c Department of Pediatrics, School of Medicine, PUCRS, Brazil
d Hospital São Lucas, PUCRS, Porto Alegre, RS, Brazil
e Department of Pediatrics, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil
f Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil
g Pediatric Emergency Department, Hospital Universitário de Santa Maria, UFSM, Brazil
h Pediatric Intensive Care Locum Consultant, Addenbrooke's Hospital, Cambridge, UK
i Pediatric NeuroCritical Care Program, CHMC, Boston, USA
j Harvard Medical School, USA
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Introduction</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Background</span><p id="par0005" class="elsevierStylePara elsevierViewall">Epileptic seizures are a common cause of pediatric emergency department visits&#46; The vast majority of seizures cease within 5<span class="elsevierStyleHsp" style=""></span>min&#59; however&#44; some are prolonged and may progress to status epilepticus &#40;SE&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> SE&#44; defined as continuous or recurring seizure activity lasting longer than 30<span class="elsevierStyleHsp" style=""></span>min&#44; is associated with major morbidity rate and carries a mortality rate of up to 20&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Prolonged seizure activity leads to failure of cerebral autoregulation&#44; which consequently reduces cerebral blood flow and eventually results in cerebral hypoxia&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Importance</span><p id="par0010" class="elsevierStylePara elsevierViewall">Benzodiazepines &#40;BZDs&#41; have been used in the urgent care of seizures for over 40 years&#44; and are considered first-line therapy for this purpose&#46; The BZDs&#44; which act on GABA<span class="elsevierStyleInf">A</span> receptors&#44; are effective in the treatment of various types of seizure&#44; have a rapid onset of action after intravenous administration&#44; excellent penetration into the central nervous system&#44; and a good safety profile&#46; Persistent generalized seizure activity increases benzodiazepine resistance&#59; therefore&#44; there is a consensus as to the need for immediate treatment of seizures&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#8211;8</span></a> Lorazepam&#44; diazepam&#44; and midazolam are the three BZDs used in this setting&#46; Lorazepam is the drug of choice due to its rapid onset of action and prolonged effect&#44; but no parenteral formulations are available in Brazil&#46; Consequently&#44; intravenous diazepam&#44; which provides seizure control in 85&#8211;90&#37; of the cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> is the first-line drug of choice for acute treatment of seizures in Brazilian practice&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Goals of this investigation</span><p id="par0015" class="elsevierStylePara elsevierViewall">When venous access is challenging or cannot be obtained&#44; the most common alternatives have been rectal diazepam and intranasal midazolam&#44; with some studies suggesting intramuscular midazolam as an additional option&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;9</span></a> The difficulty of administering BZDs rectally or intranasally and the erratic absorption provided by these routes jeopardize anticonvulsant efficacy&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;8&#44;10&#8211;13</span></a> Median time to achievement of intravenous access in children ranges from 5 to 7<span class="elsevierStyleHsp" style=""></span>min&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;11</span></a> Difficulties in obtaining venous access delay treatment and&#44; consequently&#44; increase the risk of progression to status epilepticus&#46; Thus far&#44; no consensus has been established as to the best route for administration of BZDs in the event of failed intravenous access&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The objective of this study was to compare the therapeutic efficacy of intramuscular midazolam &#40;MDZ-IM&#41; with that of intravenous diazepam &#40;DZP-IV&#41; in children admitted to the referral service of a pediatric emergency department with epileptic seizures&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Patients and methods</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Study design and setting</span><p id="par0025" class="elsevierStylePara elsevierViewall">This randomized clinical trial was carried out between August 2010 and August 2011 in a sample of children admitted to the pediatric emergency department of Santa Maria University Hospital &#40;PSPed-HUSM&#41; with epileptic seizures&#46; PSPed is a tertiary referral center in Southern Brazil&#44; staffed by dedicated pediatricians and pediatric residents&#44; which treats approximately 4000 pediatric patients per month&#46; The study was approved by the local Research Ethics Committee &#40;protocol no&#46; 0184&#46;0&#46;243&#46;000-10&#41; in accordance with the Declaration of Helsinki 1964 revised in 2008&#46; In view of the nature of the study condition and to provide the best possible benefit in this urgent setting&#44; the committee authorized immediate patient allocation and treatment without prior consent&#46; Subjects&#8217; parents or legal guardians were then notified of the trial&#44; and those who agreed to the use of patient data for research purposes were asked to provide written informed consent&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study protocol was presented by the authors and approved by the medical officers and nursing staff of the department&#44; who received specific training in its use&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Selection of participants</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Inclusion criteria&#58;</span> children between the ages of 2 months and 14 years who were admitted to the emergency department with seizures&#44; regardless of type or potential trigger&#44; and in whom anticonvulsant medication was indicated and ordered by the attending physician&#46; Children could be enrolled in the study more than once&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Exclusion criteria&#58;</span> children in whom venous access had been obtained in the prehospital setting and those with a known history of coagulopathy or hepatic and&#47;or renal impairment&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Interventions</span><p id="par0045" class="elsevierStylePara elsevierViewall">Patients admitted to the pediatric emergency department with seizures were randomly allocated to one of the two treatment groups&#58; &#40;a&#41; Intravenous diazepam &#40;DZP-IV&#41;&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg IV &#40;maximum dose 10<span class="elsevierStyleHsp" style=""></span>mg&#41; at a concentration of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;ml and with an application speed of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;min&#44; or &#40;b&#41; intramuscular midazolam &#40;MDZ-IM&#41;&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg IM &#40;maximum dose 15<span class="elsevierStyleHsp" style=""></span>mg&#41; at a concentration of 5<span class="elsevierStyleHsp" style=""></span>mg&#47;ml&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were randomized in blocks of 10&#46; Five slips of paper marked &#8220;DZP-IV&#8221; and five slips marked &#8220;MDZ-IM&#8221; were placed into a brown paper envelope&#46; At the time of admission&#44; the nurse in charge of medication administration took a slip of paper from the envelope at random and administered the corresponding drug as standardized in the study protocol&#44; after adjusting the dose for weight and age&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Methods and measurements</span><p id="par0055" class="elsevierStylePara elsevierViewall">Identifying information and physiological parameters were recorded&#46; The following variables were used as outcome measures&#58; time from admission to drug administration &#40;including time required to obtain intravenous access&#41;&#44; time from drug administration to cessation of seizures&#44; and total time from admission to cessation of seizures&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Heart rate and pulse oximetry were monitored in all patients throughout treatment&#46; Vital signs were recorded on admission and every 5<span class="elsevierStyleHsp" style=""></span>min thereafter until discharge or transfer&#46; Airway suctioning&#44; supplemental oxygen&#44; or tracheal intubation were provided as necessary or when ordered by the attending physician&#46; Immediate adverse drug reactions were assessed in the first 10<span class="elsevierStyleHsp" style=""></span>min after administration of MDZ-IM or DZP-IV&#46; The emergency department where the study was performed is equipped with crash carts containing all the necessary equipment and medications for treatment of cardiorespiratory instability&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Outcomes and analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Treatment was considered successful when cessation of seizures was achieved within 5<span class="elsevierStyleHsp" style=""></span>min of administration of a single dose of study drug &#40;DZP or MDZ&#41;&#46; Requirement of a second dose of study drug or additional medications was defined as treatment failure&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Inability to obtain venous access within 4<span class="elsevierStyleHsp" style=""></span>min was defined as &#8220;failed intravenous access&#46;&#8221; This 4-min cutoff was chosen on the basis of mean time to establish intravenous access by Pediatric Emergency nursing staff during emergency care&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Statistical analysis&#58;</span> continuous variables were expressed as means and standard deviations&#46; Comparisons were performed using Student&#39;s <span class="elsevierStyleItalic">t</span>-test &#40;for normally distributed variables&#41; or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test &#40;in case of wide variability&#41;&#46; Categorical variables were expressed as percentages and comparisons were performed with the chi-square or Fisher&#39;s exact tests&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Results</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Characteristics of study subjects</span><p id="par0080" class="elsevierStylePara elsevierViewall">Of the 180 children admitted to the Pediatric Emergency Department at Santa Maria University Hospital &#40;Brazil&#41; with a chief complaint of convulsive seizures&#44; 144 were postictal on arrival&#46; The remaining 36 children were enrolled in the study&#46; Of these&#44; 16 were allocated to the MDZ-IM group and 20 to the DZP-IV group&#46; All children allocated to the midazolam group completed the study&#46; Of those allocated to the diazepam arm&#44; four &#40;20&#37;&#41; were excluded due to failed intravenous access&#44; and the remaining 16 completed the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The parents or guardians of all 32 children who completed the study had provided informed consent for participation&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">There were no significant between-group differences in age&#44; weight&#44; sex&#44; seizure etiology&#44; vital signs&#44; or blood glucose levels on admission&#46; In both groups&#44; most children were under the age of 5 &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Main results</span><p id="par0090" class="elsevierStylePara elsevierViewall">In 14 patients in each group &#40;87&#46;5&#37;&#41;&#44; seizure activity ceased after administration of a single BZD dose&#44; which shows that both intramuscular midazolam and intravenous diazepam are effective anticonvulsants&#46; Two patients in each group &#40;12&#46;5&#37;&#41; required a second dose of study drug or additional medications for seizure control &#40;treatment failure&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In the MDZ-IM group&#44; active treatment was instituted significantly sooner than in the DZP-IV group &#40;2&#46;8 versus 7&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Total time to cessation of seizures was also significantly shorter in the MZD-IM group &#40;time between admission and seizure cessation&#44; 7&#46;3 versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; However&#44; time from drug administration to cessation of seizures was significantly shorter in the DZP-IV group &#40;3&#46;3 versus 4&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">As noted above&#44; two patients in each group &#40;12&#46;5&#37;&#41; were considered to have failed treatment due to persistence of seizures more than 5<span class="elsevierStyleHsp" style=""></span>min after BZD administration&#46; The between-group differences in time to active treatment and time to cessation of seizures held true regardless of inclusion or exclusion of the patients that failed treatment &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All children in both groups exhibited cyanosis and psychomotor agitation on admission and required supplemental oxygen by nasal cannula or non-rebreather mask&#46; One child in the DZP-IV group progressed to SE of 40-min duration&#44; requiring phenytoin for seizure control&#44; and one child had a seizure duration of 6<span class="elsevierStyleHsp" style=""></span>min&#44; requiring only an additional dose of IV diazepam&#46; In the MDZ-IM group&#44; one child had a seizure lasting 10<span class="elsevierStyleHsp" style=""></span>min&#44; requiring intravenous diazepam and phenytoin&#46; Additionally&#44; one child in the MDZ group had SE that lasted 55<span class="elsevierStyleHsp" style=""></span>min and did not respond to intravenous diazepam&#46; In this case&#44; cessation was achieved after rectal diazepam and an additional dose of intramuscular midazolam&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">One child &#40;6&#46;25&#37;&#41; in the MDZ group required intubation&#44; artificial ventilation&#44; and ICU admission due to respiratory failure on admission to the ED &#40;SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#37;&#41;&#46; Two children &#40;12&#46;5&#37;&#41; in the DZP group required intubation and ICU admission &#40;one due to severe head trauma and one due to respiratory failure with SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>80&#37;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">All children were monitored until cessation of seizures or discharge&#46; There were no significant between-group differences in vital signs &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Possible immediate adverse drug reactions &#40;those occurring within 10<span class="elsevierStyleHsp" style=""></span>min of study drug administration&#41; included hypotension in one child &#40;6&#46;3&#37;&#41; in the MDZ-IM group&#44; two children &#40;12&#46;6&#37;&#41; with hyperactivity and salivation&#44; one &#40;6&#46;3&#37;&#41; with nausea&#44; and two &#40;12&#46;6&#37;&#41; with vomiting in the DZP-IV group&#46; Nevertheless&#44; the between-group difference in adverse reactions did not reach statistical significance &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">In this randomized clinical trial where intramuscular midazolam was compared with intravenous diazepam for treatment of seizures in the pediatric emergency department&#44; the following findings were observed&#58; &#40;a&#41; in a reasonably high percentage of patients &#40;20&#37;&#41;&#44; intravenous access cannot be achieved within 5<span class="elsevierStyleHsp" style=""></span>min of admission&#59; &#40;b&#41; time from admission to active treatment and time from admission to cessation of seizures are significantly shorter with IM midazolam&#59; and&#44; the previous finding notwithstanding&#44; &#40;c&#41; time from drug administration to cessation of seizures is significantly shorter with IV diazepam instead of IM midazolam&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Current treatment protocols propose that all children with convulsive seizures of &#62;5-min duration should be managed according to established treatment algorithms for status epilepticus&#44; in view of the complications and risk of neurological damage associated with prolonged seizure activity&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The first 10<span class="elsevierStyleHsp" style=""></span>min of management should focus on protecting the airway and maintaining its patency&#44; providing supplemental oxygen&#44; measuring blood glucose&#44; obtaining intravenous access&#44; and treating the seizure with an intravenous benzodiazepine&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;8</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">One may presume that the minimum time required for a child to reach the emergency department after the onset of seizures&#44; when transported from the home by parents&#44; is 5<span class="elsevierStyleHsp" style=""></span>min&#46; Studies have estimated that at least 5&#8211;7<span class="elsevierStyleHsp" style=""></span>min are required to obtain intravenous access in pediatric patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;11</span></a> The sum of these times means at least 10&#8211;12<span class="elsevierStyleHsp" style=""></span>min will have elapsed between seizure onset and active treatment&#44; which increases the risk of complications&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">When intravenous access cannot be obtained&#44; buccal or intranasal administration of midazolam has been advocated&#44; with an effectiveness rate in the region of 60&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Despite good absorption through the mucous membranes of the mouth and nose&#44; administration of midazolam through these routes can be extraordinarily challenging due to the involuntary movements of the convulsing child and due to the presence of airway secretion&#44; which impedes proper absorption&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;13</span></a> Rectal administration of diazepam is associated with erratic absorption and poor therapeutic success rates &#40;27&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;12</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Midazolam has been used in the treatment of seizures since the 1980s&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> with a good safety profile in terms of respiratory depression and good absorption via several routes &#40;intranasal&#44; buccal&#44; rectal&#44; and intramuscular&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;15&#8211;17</span></a> A study conducted in pediatric emergency departments in Australia and New Zealand showed that&#44; when venous access could not be obtained&#44; 49&#37; of the physicians used rectal diazepam and 41&#37; used intramuscular midazolam&#44; which shows increasing preference for the intramuscular route&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">As in previous studies&#44; IV diazepam has a faster onset of action than IM midazolam after administration &#40;3&#46;3<span class="elsevierStyleHsp" style=""></span>min versus 4&#46;4<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; due to the shorter time to peak serum levels and&#44; consequently&#44; earlier achievement of therapeutic levels in the CNS&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;11&#44;19</span></a> Nevertheless&#44; actual time to cessation of seizures &#40;i&#46;e&#46; time from admission to the emergency department to cessation of seizure activity&#41; was significantly shorter in the IM midazolam group &#40;7&#46;3<span class="elsevierStyleHsp" style=""></span>min versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#41;&#44; which corroborates the observations of a similar trial&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">These results suggest that&#44; when treating children with convulsive seizures in whom venous access is expected to be difficult or unlikely&#44; IM administration of midazolam is safe&#44; effective&#44; and perhaps superior to intravenous diazepam&#46; It bears stressing that seizure duration is directly associated with the speed of benzodiazepine administration&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Similar findings have been reported in the treatment of behavioral disturbances in adult patients &#40;where intravenous access is also challenging&#41;&#44; where IM administration was superior to IV sedation in terms of time to cessation of psychomotor agitation &#40;21<span class="elsevierStyleHsp" style=""></span>min versus 30<span class="elsevierStyleHsp" style=""></span>min&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Therefore&#44; even though BZDs act more rapidly when administered by the intravenous route&#44; early intramuscular administration of midazolam provides superior therapeutic efficacy&#44; due to faster administration as well as due to the excellent absorption of midazolam by this route&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Failed intravenous access is widely recognized as a hindrance to implementation of urgent care protocols in the pediatric emergency department&#46; It is estimated that 2&#46;5&#8211;16<span class="elsevierStyleHsp" style=""></span>min are required to obtain peripheral venous access in adults&#44; with a failure rate of 10&#8211;40&#37;&#46; In children&#44; this rate ranges from 14&#37; to 70&#37;&#44; with failure being most common in infants&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;22&#8211;24</span></a> Venous access could not be obtained in 20&#37; of the 20 children randomized to the DZP-IV arm of this study&#44; which provides further evidence of the importance of intramuscular administration of anticonvulsants in this setting&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Adverse effects were more frequent in the diazepam group&#44; as expected in view of previous comparisons with midazolam and lorazepam&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;19</span></a> although the difference did not reach statistical significance&#46; The adverse effects of BZDs are usually dose-dependent and associated with repeated administration&#44; and manifest most commonly as reduced oxygen saturation and central hypoventilation&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a> These findings are rapidly reversed with administration of supplemental oxygen&#44; airway suctioning and positional maneuvers and&#44; in a minority of cases&#44; bag-valve-mask ventilation&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The etiology of seizures varies according to age and geographical region&#46; However&#44; most studies report that approximately one-third of children admitted to an emergency department with convulsions are having a febrile seizure&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#8211;27</span></a> as was the case in the present study&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">One limitation of this study is that the sample size precludes any conclusions about adverse effects and drug safety&#44; which would require a larger population&#46; Furthermore&#44; due to the design and nature of the study&#44; personnel in charge of administering drugs were not blinded to allocation&#44; which may have introduced bias&#46; Despite this limitation&#44; the times to seizure cessation obtained in this study were highly favorable&#44; especially in view of the study setting &#40;the dedicated pediatric emergency department of a large&#44; university-affiliated tertiary care center&#41;&#46; One may presume that at smaller hospitals&#44; where staff might have less skill or experience obtaining intravenous access in children&#44; the difference would be even more significant&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Another limitation of the present study is the fact that&#44; although the cause of seizure could be initially identified at the emergency room in most patients&#44; this initial identification does reach a 100&#37; level of certainty&#46; Therefore&#44; emergency room professionals may have failed to identify&#44; at first&#44; a child with an underlying neurological disease leading to unresponsiveness to seizure treatment&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The results of the study suggest that intramuscular midazolam significantly shortens seizure duration in children as compared with intravenous diazepam&#46; Therefore&#44; intramuscular midazolam is a good alternative to intravenous diazepam&#44; in view of its anticonvulsant efficacy and speed and ease of administration in the pediatric emergency care setting&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Authors&#8217; contribution</span><p id="par0195" class="elsevierStylePara elsevierViewall">All authors took part in data collection and analysis&#44; literature review&#44; and drafting of the manuscript&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Patients and methods"
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              "titulo" => "Characteristics of study subjects"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2013-12-09"
    "fechaAceptado" => "2014-04-03"
    "PalabrasClave" => array:2 [
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            0 => "Seizures"
            1 => "Benzodiazepines"
            2 => "Status epilepticus"
            3 => "Epilepsy"
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            0 => "Convulsiones"
            1 => "Benzodiazep&#237;nicos"
            2 => "Estado epil&#233;ptico"
            3 => "Epilepsia"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Aim</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare the therapeutic efficacy of intramuscular midazolam &#40;MDZ-IM&#41; with that of intravenous diazepam &#40;DZP-IV&#41; for seizures in children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Randomized clinical trial&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pediatric emergency department&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients&#58; Children aged 2 months to 14 years admitted to the study facility with seizures&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Intervention</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patients were randomized to receive DZP-IV or MDZ-IM&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Main measurements</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Groups were compared with respect to time to treatment start &#40;min&#41;&#44; time from drug administration to seizure cessation &#40;min&#41;&#44; time to seizure cessation &#40;min&#41;&#44; and rate of treatment failure&#46; Treatment was considered successful when seizure cessation was achieved within 5<span class="elsevierStyleHsp" style=""></span>min of drug administration&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Overall&#44; 32 children &#40;16 per group&#41; completed the study&#46; Intravenous access could not be obtained within 5<span class="elsevierStyleHsp" style=""></span>min in four patients &#40;25&#37;&#41; in the DZP-IV group&#46; Time from admission to active treatment and time to seizure cessation was shorter in the MDZ-IM group &#40;2&#46;8 versus 7&#46;4<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001 and 7&#46;3 versus 10&#46;6<span class="elsevierStyleHsp" style=""></span>min&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;006&#44; respectively&#41;&#46; In two children per group &#40;12&#46;5&#37;&#41;&#44; seizures continued after 10<span class="elsevierStyleHsp" style=""></span>min of treatment&#44; and additional medications were required&#46; There were no between-group differences in physiological parameters or adverse events &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;171&#41;&#59; one child &#40;6&#46;3&#37;&#41; developed hypotension in the MDZ-IM group and five &#40;31&#37;&#41; developed hyperactivity or vomiting in the DZP-IV group&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Given its efficacy and ease and speed of administration&#44; intramuscular midazolam is an excellent option for treatment of childhood seizures&#44; enabling earlier treatment and shortening overall seizure duration&#46; There were no differences in complications when applying MDZ-IM or DZP-IV&#46;</p></span>"
        "secciones" => array:7 [
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        "resumen" => "<span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparar la eficacia de midazolam intramuscular &#40;MDZ-IM&#41; con la de diazepam intravenoso &#40;DZP-IV&#41; para convulsiones en ni&#241;os&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Ensayo cl&#237;nico aleatorizado&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">&#193;mbito</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Servicio de Urgencias Pedi&#225;tricas&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Pacientes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Ni&#241;os de entre 2 meses y 14 a&#241;os internados con convulsiones&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Intervenci&#243;n</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron aleatorizados para recibir DZP-IV o MDZ-IM&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Mediciones principales</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Tiempo hasta el inicio del tratamiento &#40;minutos&#41;&#44; tiempo entre la administraci&#243;n del medicamento y el cese de la convulsi&#243;n &#40;minutos&#41;&#44; tiempo hasta el cese de la convulsi&#243;n &#40;minutos&#41;&#44; y tasa de fallo del tratamiento&#46; El tratamiento fue considerado exitoso cuando las convulsiones cesaron en los 5<span class="elsevierStyleHsp" style=""></span>min tras la administraci&#243;n del medicamento&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Completaron el estudio 32 ni&#241;os &#40;16 por grupo&#41;&#46; No fue posible obtener acceso intravenoso en 4 pacientes &#40;25&#37;&#41; del grupo DZP-IV&#46; El tiempo entre la internaci&#243;n y el tratamiento fue menor en el grupo MDZ-IM &#40;2&#44;8 vs&#46; 7&#44;4 min&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; as&#237; como el tiempo hasta el cese de la convulsi&#243;n &#40;7&#44;3 vs&#46; 10&#44;6 min&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41;&#46; En 2 ni&#241;os de cada grupo &#40;12&#44;5&#37;&#41;&#44; las convulsiones continuaron despu&#233;s de 10<span class="elsevierStyleHsp" style=""></span>min de tratamiento&#46; No hubo diferencias entre los grupos en los par&#225;metros fisiol&#243;gicos o eventos adversos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;171&#41;&#59; un ni&#241;o &#40;6&#44;3&#37;&#41; del grupo MDZ-IM present&#243; hipotensi&#243;n&#44; y 5 del grupo DZP-IV &#40;31&#37;&#41; presentaron hiperactividad o v&#243;mitos&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusi&#243;n</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Dada su eficacia&#44; facilidad y velocidad de administraci&#243;n&#44; MDZ-IM es una excelente opci&#243;n para el tratamiento de convulsiones infantiles&#44; posibilitando un tratamiento precoz y reduciendo la duraci&#243;n de la convulsi&#243;n&#46; No hubo diferencias en las complicaciones al aplicar MDZ-IM o DZP-IV&#46;</p></span>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Body temperature &#40;&#176;C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;670<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Heart rate &#40;bpm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">149&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>31&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;289<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Respiratory rate &#40;bpm&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;985<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Oxygen saturation &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;846<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Blood glucose &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;955<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Age</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">5 years&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;75&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;62&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Febrile seizures&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Time from active treatment to cessation of seizures &#40;min&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr></tbody></table>
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                    0 => array:2 [
                      "titulo" => "Midazolam versus diazepam for the treatment of status epilepticus in children and young adults&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; McMullan"
                            1 => "C&#46; Sasson"
                            2 => "A&#46; Pancioli"
                            3 => "R&#46; Silbergleit"
                          ]
                        ]
                      ]
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