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since the patient movements may be very small&#44; inconsistent and easily exhausted&#8211;thus giving rise to erroneous diagnostic interpretations&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> It has been estimated that 40&#37; of all cases of VS actually constitute MCS<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a>&#8211;a circumstance that reflects the need to complement clinical exploration with other diagnostic methods&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Positron emission tomography&#8211;computed tomography &#40;PET&#47;CT&#41; is an emerging neuroimaging technique that can differentiate between VS and MCS&#46; Its availability is still limited&#44; however&#44; and interpretation of the findings is sometimes difficult<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a>&#46; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-2-fluoro-2-deoxy-<span class="elsevierStyleSmallCaps">d</span>-glucose &#40;<span class="elsevierStyleSup">18</span>F-FDG&#41;&#8211;a radiolabeled glucose analog&#8211;can be used to study brain activity&#46; <span class="elsevierStyleSup">18</span>F-FDG uptake is related to cell transport&#44; and thus assesses regional cerebral carbohydrate metabolism&#44; representing an <span class="elsevierStyleItalic">in vivo</span> measurement of neuronal integrity&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> In recent years&#44; several studies have correlated specific metabolic patterns to different levels of consciousness&#46; In this regard&#44; patients presenting VS show marked global frontal and parietal cortical hypometabolism&#44; while MCS is characterized by preserved metabolism of these cortical areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">7&#8211;11</span></a> One of the limitations of PET&#47;CT is that it requires the patient to be moved out of the Intensive Care Unit &#40;ICU&#41;&#44; and the exploration moreover takes about 1<span class="elsevierStyleHsp" style=""></span>h to complete&#46; Specifically&#44; the time from injection of the radiotracer to adequate distribution of the radiodrug is about 40&#8211;45<span class="elsevierStyleHsp" style=""></span>min&#44; and another 10&#8211;15<span class="elsevierStyleHsp" style=""></span>min are needed for image acquisition&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a clinical case in which PET&#47;CT was able to discard VS&#46; The patient was a 15-year-old male presenting cardiorespiratory arrest with atrial fibrillation secondary to electrocution&#46; After 10<span class="elsevierStyleHsp" style=""></span>min of basic cardiopulmonary resuscitation &#40;CPR&#41;&#44; he was attended by the out-hospital emergency service&#44; which performed advanced CPR during 15<span class="elsevierStyleHsp" style=""></span>min&#44; requiring 6 defibrillatory discharges and intravenous amiodarone&#46; Following admission to the ICU&#44; therapeutic hypothermia was carried out for 36<span class="elsevierStyleHsp" style=""></span>h&#46; The initial bispectral index &#40;BIS&#41; score was &#60;15&#44; and the brain CT findings proved normal&#46; Sedation was suspended after 72<span class="elsevierStyleHsp" style=""></span>h&#44; and the patient was able to follow simple instructions&#44; with a Glasgow coma score of 10&#46; On day 4 of admission he suffered an important worsening of consciousness and dystonic episodes&#44; with right deviation of the gaze and reactive mydriasis&#46; Antiseizure medication was prescribed&#46; The electroencephalogram &#40;EEG&#41;&#44; median nerve somatosensory evoked potentials &#40;SEPs&#41; and brainstem auditory evoked potentials were normal&#46; Repeat CT discarded ischemic&#47;hemorrhagic damage&#44; and the brain magnetic resonance imaging &#40;MRI&#41; study revealed bilateral basal ganglia and hippocampal cortical signal alterations consistent with severe anoxic encephalopathy&#46; Following the suspension of sedation&#44; status dystonicus&#44; opisthotonus and diencephalic alterations were observed with paroxysmal sympathetic hyperactivity&#44; arterial hypertension&#44; perspiration and tachycardia&#46; SPECT with <span class="elsevierStyleSup">99m</span>Tc-HMPAO revealed occipital cortical and basal ganglia hyperperfusion&#46; In the course of admission&#44; antiseizure treatment was administered in the form of levetiracetam&#44; valproic acid&#44; lacosamide&#44; phenobarbital and clonazepam&#44; with the unsuccessful evaluation of a number of combinations and dosing schemes&#46; Treatment with clonidine&#44; propranolol&#44; morphine and baclofen partially controlled the sympathetic activity&#46; In view of the extreme status dystonicus that made patient handling and care impossible&#44; barbiturate-induced coma with thiopental sodium was decided&#46; After suspending thiopental&#44; the crises returned with the same frequency and intensity&#44; with the maintenance of status dystonicus&#46; During the brief intercrisis intervals&#44; some observers had the impression that the patient seemed to follow instructions&#44; though the explorations were not reproducible&#44; and there were many doubts regarding his level of consciousness&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In view of the magnitude and severity of the crises&#44; manifesting continuously 24<span class="elsevierStyleHsp" style=""></span>h a day and requiring deep sedoanalgesia and relaxation&#44; we were unable to assess the level of consciousness of the patient&#46; In this context&#44; and in order to progress in the clinical decision making process&#44; we performed PET&#47;CT with <span class="elsevierStyleSup">18</span>F-FDG &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The exploration revealed marked hypometabolism in both posterior putamina&#44; coinciding with the signal alteration described in the previous MRI scan&#44; together with preserved carbohydrate metabolism in the caudate nuclei consistent with the SPECT hyperperfusion findings&#46; Metabolism of the frontoparietal cortex was within normal limits&#46; Consequently&#44; based on the literature&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> the findings were not suggestive of a metabolic pattern consistent with VS&#46; Since the glucose-consuming cortical activity was normal&#44; we concluded that the lack of patient contact with the environment was related to the status dystonicus and sedation used to control the condition&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Given the refractory clinical condition&#44; and upon recommendation from experts in movement disorders and epilepsy&#44; we tried new antiseizure treatment schemes&#44; infiltration with botulinum toxin&#44; and the use of different drugs and drug combinations &#40;bromocriptine&#44; gabapentin&#44; dantrolene&#44; piracetam&#44; biperiden&#44; dronabinol plus cannabidiol&#44; intrathecal baclofen&#44; olanzapine&#44; chloral hydrate&#44; trihexyphenidyl&#44; clorazepate&#44; perampanel&#44; tetrabenazine&#44; tizanidine&#44; fluoxetine&#44; paroxetine&#44; benzodiazepines and cisatracurium&#41;&#8211;though without achieving dystonia control&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The control CT and MRI studies &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; in the second month of admission revealed almost complete destruction of the basal ganglia as a result of the electrocution and anoxic damage&#46; Repeat PET&#47;CT performed 6 months after the first exploration confirmed destruction of the basal ganglia and the preservation of frontoparietal cortical metabolism&#46; In order to control the status dystonicus&#44; two neurostimulators were implanted in both cerebral thalami&#46; Although this measure partially improved the clinical manifestations&#44; the crises again could not be fully controlled&#46; An intrathecal morphine pump allowed gradual reduction of the cisatracurium and benzodiazepine perfusion doses to the point of suspension of the medication&#8211;the patient at present receiving only a 5<span class="elsevierStyleHsp" style=""></span>mg diazepam dose every 8<span class="elsevierStyleHsp" style=""></span>h <span class="elsevierStyleItalic">via</span> the enteral route&#46; Status dystonicus has a very poor prognosis&#44; since all the imaging studies show catastrophic structural damage&#44; with almost complete disappearance of the basal ganglia&#46; However&#44; at present&#44; the neurostimulators&#44; morphine pump&#44; periodic botulinum toxin infiltrations&#44; rehabilitation and drug treatment with diazepam and baclofen afford an acceptable degree of control of the dystonias&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was discharged from the ICU after 11 months of admission fully conscious&#44; oriented and cooperative&#46; He preserves higher mental functions that allow him to play chess and to express and manifest complex emotions&#46; He also has a degree of motor coordination that even allows him to play with a ball and take some steps with help&#46; Within the limitations posed by the tracheostomy cannula&#44; he shows acceptable communication with his family and the health professionals&#46; The patient is currently fed through a percutaneous gastrostomy tube&#46; Phoniatric evaluation is pending for decannulation and the start of an oral diet if swallowing function is adequate&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-2-fluoro-2-deoxy-<span class="elsevierStyleSmallCaps">d</span>-glucose can be used to explore brain metabolism and cortical glucose consumption&#44; discarding or confirming VS&#8211;this being very important in deciding the limitation of life-sustaining treatment&#46; Positron emission tomography&#8211;computed tomography appears to be a very useful tool for establishing the functional outcome of critical patients with anoxic damage&#8211;such assessment being crucial in daily clinical practice&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have received no financial support for carrying out this study&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Astola I&#44; Escudero D&#44; Forcelledo L&#44; Vi&#241;a L&#44; Vigil C&#44; Gonz&#225;lez F&#46; Utilidad del estudio metab&#243;lico cerebral con PET&#47;TC <span class="elsevierStyleSup">18</span>F-fluorodeoxiglucosa para descartar estado vegetativo&#46; Med Intensiva&#46; 2017&#59;41&#58;127&#8211;129&#46;</p>"
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Scientific letter
The role of 18F-fluorodeoxyglucose PET/CT in ruling out vegetative state
Utilidad del estudio metabólico cerebral con PET/TC 18F-fluorodeoxiglucosa para descartar estado vegetativo
I. Astolaa,
Corresponding author
iastolahidalgo@gmail.com

Corresponding author.
, D. Escuderoa, L. Forcelledoa, L. Viñaa, C. Vigilb, F. Gonzálezb
a Department of Intensive Care Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Department of Nuclear Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Patients in the vegetative state &#40;VS&#41; generally remain in the same clinical situation&#44; though some may evolve toward a minimally conscious state &#40;MCS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;2</span></a> It is very important to differentiate these two conditions&#44; since the associated clinical decisions may be very distinct and pose different ethical dilemmas&#46; In the case of permanent VS&#44; characterized by irreversible damage&#44; limitation of life-sustaining treatment may be decided&#46; In comparison&#44; patients presenting MCS are unable to maintain functional communication&#44; but are occasionally able to follow instructions&#44; utter some words&#44; visually follow moving objects or people&#44; and show emotions such as smiling&#44; laughing or even crying&#46; Neurological exploration in such cases is extremely difficult&#44; since the patient movements may be very small&#44; inconsistent and easily exhausted&#8211;thus giving rise to erroneous diagnostic interpretations&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> It has been estimated that 40&#37; of all cases of VS actually constitute MCS<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a>&#8211;a circumstance that reflects the need to complement clinical exploration with other diagnostic methods&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Positron emission tomography&#8211;computed tomography &#40;PET&#47;CT&#41; is an emerging neuroimaging technique that can differentiate between VS and MCS&#46; Its availability is still limited&#44; however&#44; and interpretation of the findings is sometimes difficult<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a>&#46; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-2-fluoro-2-deoxy-<span class="elsevierStyleSmallCaps">d</span>-glucose &#40;<span class="elsevierStyleSup">18</span>F-FDG&#41;&#8211;a radiolabeled glucose analog&#8211;can be used to study brain activity&#46; <span class="elsevierStyleSup">18</span>F-FDG uptake is related to cell transport&#44; and thus assesses regional cerebral carbohydrate metabolism&#44; representing an <span class="elsevierStyleItalic">in vivo</span> measurement of neuronal integrity&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> In recent years&#44; several studies have correlated specific metabolic patterns to different levels of consciousness&#46; In this regard&#44; patients presenting VS show marked global frontal and parietal cortical hypometabolism&#44; while MCS is characterized by preserved metabolism of these cortical areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">7&#8211;11</span></a> One of the limitations of PET&#47;CT is that it requires the patient to be moved out of the Intensive Care Unit &#40;ICU&#41;&#44; and the exploration moreover takes about 1<span class="elsevierStyleHsp" style=""></span>h to complete&#46; Specifically&#44; the time from injection of the radiotracer to adequate distribution of the radiodrug is about 40&#8211;45<span class="elsevierStyleHsp" style=""></span>min&#44; and another 10&#8211;15<span class="elsevierStyleHsp" style=""></span>min are needed for image acquisition&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a clinical case in which PET&#47;CT was able to discard VS&#46; The patient was a 15-year-old male presenting cardiorespiratory arrest with atrial fibrillation secondary to electrocution&#46; After 10<span class="elsevierStyleHsp" style=""></span>min of basic cardiopulmonary resuscitation &#40;CPR&#41;&#44; he was attended by the out-hospital emergency service&#44; which performed advanced CPR during 15<span class="elsevierStyleHsp" style=""></span>min&#44; requiring 6 defibrillatory discharges and intravenous amiodarone&#46; Following admission to the ICU&#44; therapeutic hypothermia was carried out for 36<span class="elsevierStyleHsp" style=""></span>h&#46; The initial bispectral index &#40;BIS&#41; score was &#60;15&#44; and the brain CT findings proved normal&#46; Sedation was suspended after 72<span class="elsevierStyleHsp" style=""></span>h&#44; and the patient was able to follow simple instructions&#44; with a Glasgow coma score of 10&#46; On day 4 of admission he suffered an important worsening of consciousness and dystonic episodes&#44; with right deviation of the gaze and reactive mydriasis&#46; Antiseizure medication was prescribed&#46; The electroencephalogram &#40;EEG&#41;&#44; median nerve somatosensory evoked potentials &#40;SEPs&#41; and brainstem auditory evoked potentials were normal&#46; Repeat CT discarded ischemic&#47;hemorrhagic damage&#44; and the brain magnetic resonance imaging &#40;MRI&#41; study revealed bilateral basal ganglia and hippocampal cortical signal alterations consistent with severe anoxic encephalopathy&#46; Following the suspension of sedation&#44; status dystonicus&#44; opisthotonus and diencephalic alterations were observed with paroxysmal sympathetic hyperactivity&#44; arterial hypertension&#44; perspiration and tachycardia&#46; SPECT with <span class="elsevierStyleSup">99m</span>Tc-HMPAO revealed occipital cortical and basal ganglia hyperperfusion&#46; In the course of admission&#44; antiseizure treatment was administered in the form of levetiracetam&#44; valproic acid&#44; lacosamide&#44; phenobarbital and clonazepam&#44; with the unsuccessful evaluation of a number of combinations and dosing schemes&#46; Treatment with clonidine&#44; propranolol&#44; morphine and baclofen partially controlled the sympathetic activity&#46; In view of the extreme status dystonicus that made patient handling and care impossible&#44; barbiturate-induced coma with thiopental sodium was decided&#46; After suspending thiopental&#44; the crises returned with the same frequency and intensity&#44; with the maintenance of status dystonicus&#46; During the brief intercrisis intervals&#44; some observers had the impression that the patient seemed to follow instructions&#44; though the explorations were not reproducible&#44; and there were many doubts regarding his level of consciousness&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In view of the magnitude and severity of the crises&#44; manifesting continuously 24<span class="elsevierStyleHsp" style=""></span>h a day and requiring deep sedoanalgesia and relaxation&#44; we were unable to assess the level of consciousness of the patient&#46; In this context&#44; and in order to progress in the clinical decision making process&#44; we performed PET&#47;CT with <span class="elsevierStyleSup">18</span>F-FDG &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The exploration revealed marked hypometabolism in both posterior putamina&#44; coinciding with the signal alteration described in the previous MRI scan&#44; together with preserved carbohydrate metabolism in the caudate nuclei consistent with the SPECT hyperperfusion findings&#46; Metabolism of the frontoparietal cortex was within normal limits&#46; Consequently&#44; based on the literature&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> the findings were not suggestive of a metabolic pattern consistent with VS&#46; Since the glucose-consuming cortical activity was normal&#44; we concluded that the lack of patient contact with the environment was related to the status dystonicus and sedation used to control the condition&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Given the refractory clinical condition&#44; and upon recommendation from experts in movement disorders and epilepsy&#44; we tried new antiseizure treatment schemes&#44; infiltration with botulinum toxin&#44; and the use of different drugs and drug combinations &#40;bromocriptine&#44; gabapentin&#44; dantrolene&#44; piracetam&#44; biperiden&#44; dronabinol plus cannabidiol&#44; intrathecal baclofen&#44; olanzapine&#44; chloral hydrate&#44; trihexyphenidyl&#44; clorazepate&#44; perampanel&#44; tetrabenazine&#44; tizanidine&#44; fluoxetine&#44; paroxetine&#44; benzodiazepines and cisatracurium&#41;&#8211;though without achieving dystonia control&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The control CT and MRI studies &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; in the second month of admission revealed almost complete destruction of the basal ganglia as a result of the electrocution and anoxic damage&#46; Repeat PET&#47;CT performed 6 months after the first exploration confirmed destruction of the basal ganglia and the preservation of frontoparietal cortical metabolism&#46; In order to control the status dystonicus&#44; two neurostimulators were implanted in both cerebral thalami&#46; Although this measure partially improved the clinical manifestations&#44; the crises again could not be fully controlled&#46; An intrathecal morphine pump allowed gradual reduction of the cisatracurium and benzodiazepine perfusion doses to the point of suspension of the medication&#8211;the patient at present receiving only a 5<span class="elsevierStyleHsp" style=""></span>mg diazepam dose every 8<span class="elsevierStyleHsp" style=""></span>h <span class="elsevierStyleItalic">via</span> the enteral route&#46; Status dystonicus has a very poor prognosis&#44; since all the imaging studies show catastrophic structural damage&#44; with almost complete disappearance of the basal ganglia&#46; However&#44; at present&#44; the neurostimulators&#44; morphine pump&#44; periodic botulinum toxin infiltrations&#44; rehabilitation and drug treatment with diazepam and baclofen afford an acceptable degree of control of the dystonias&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was discharged from the ICU after 11 months of admission fully conscious&#44; oriented and cooperative&#46; He preserves higher mental functions that allow him to play chess and to express and manifest complex emotions&#46; He also has a degree of motor coordination that even allows him to play with a ball and take some steps with help&#46; Within the limitations posed by the tracheostomy cannula&#44; he shows acceptable communication with his family and the health professionals&#46; The patient is currently fed through a percutaneous gastrostomy tube&#46; Phoniatric evaluation is pending for decannulation and the start of an oral diet if swallowing function is adequate&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-2-fluoro-2-deoxy-<span class="elsevierStyleSmallCaps">d</span>-glucose can be used to explore brain metabolism and cortical glucose consumption&#44; discarding or confirming VS&#8211;this being very important in deciding the limitation of life-sustaining treatment&#46; Positron emission tomography&#8211;computed tomography appears to be a very useful tool for establishing the functional outcome of critical patients with anoxic damage&#8211;such assessment being crucial in daily clinical practice&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have received no financial support for carrying out this study&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Astola I&#44; Escudero D&#44; Forcelledo L&#44; Vi&#241;a L&#44; Vigil C&#44; Gonz&#225;lez F&#46; Utilidad del estudio metab&#243;lico cerebral con PET&#47;TC <span class="elsevierStyleSup">18</span>F-fluorodeoxiglucosa para descartar estado vegetativo&#46; Med Intensiva&#46; 2017&#59;41&#58;127&#8211;129&#46;</p>"
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Article information
ISSN: 21735727
Original language: English
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2022 October 128 40 168
2022 September 87 39 126
2022 August 84 50 134
2022 July 72 44 116
2022 June 82 37 119
2022 May 83 50 133
2022 April 90 50 140
2022 March 93 71 164
2022 February 101 36 137
2022 January 107 46 153
2021 December 125 60 185
2021 November 117 66 183
2021 October 118 81 199
2021 September 104 46 150
2021 August 77 35 112
2021 July 67 38 105
2021 June 69 35 104
2021 May 122 54 176
2021 April 184 100 284
2021 March 170 34 204
2021 February 132 31 163
2021 January 115 34 149
2020 December 95 20 115
2020 November 98 30 128
2020 October 56 28 84
2020 September 78 17 95
2020 August 44 17 61
2020 July 65 27 92
2020 June 48 12 60
2020 May 47 14 61
2020 April 58 23 81
2020 March 34 18 52
2020 February 147 26 173
2020 January 57 42 99
2019 December 64 31 95
2019 November 38 26 64
2019 October 51 18 69
2019 September 44 18 62
2019 August 41 19 60
2019 July 43 24 67
2019 June 38 18 56
2019 May 73 40 113
2019 April 43 19 62
2019 March 37 26 63
2019 February 31 22 53
2019 January 55 48 103
2018 December 48 43 91
2018 November 110 83 193
2018 October 66 25 91
2018 September 47 12 59
2018 August 26 6 32
2018 July 42 12 54
2018 June 53 7 60
2018 May 37 3 40
2018 April 43 10 53
2018 March 74 3 77
2018 February 22 5 27
2018 January 52 19 71
2017 December 36 14 50
2017 November 34 8 42
2017 October 35 5 40
2017 September 26 10 36
2017 August 25 12 37
2017 July 27 21 48
2017 June 16 11 27
2017 April 1 0 1
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?