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describe its kinetic within 48<span class="elsevierStyleHsp" style=""></span>h post-bleeding and assess its role as a possible outcome predictor&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">For this purpose&#44; we included patients admitted to the NeuroCritical Care Unit &#40;NCCU&#41; at Virgen del Roc&#237;o University Hospital in Seville&#44; Spain&#44; with the diagnosis of aSAH during a 5-month long period&#46; The protocol&#44; carried out in accordance with the Declaration of Helsinki&#44; was approved by our hospital Institution Review Board&#46; Written informed consent was obtained from patients family members&#46; aSAH were eligible based on the following inclusion criteria&#58; aged 18 or over&#44; clinical history of SAH with evidence of bleeding on CT scan&#44; NCCU admission within 24<span class="elsevierStyleHsp" style=""></span>h of onset&#44; absence of tumor&#44; trauma&#44; previous episodes of SAH or any other neurological disease that could modify results&#46; Clinical and demographic variables&#44; collected prospectively&#44; included&#58; gender&#44; age&#44; Glasgow Coma Scale &#40;GCS&#41;&#44; Hunt and Hess &#40;HH&#41; classification&#44; World Federation of Neurological Surgeons &#40;WFNS&#41; scale&#44; Modified Fisher grade and 6-month mortality&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">During the recruitment period&#44; 15 aSAH patients fulfilled the inclusion criteria&#46; Venous blood samples were collected on admission and 48<span class="elsevierStyleHsp" style=""></span>h after the bleeding&#46; Additionally&#44; a group of 10 healthy subjects were volunteers to extract a blood sample&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Serum gelsolin was measured using a double-antibody sandwich commercialized by Cloud-Clone Corp&#46; &#40;CCC&#44; USA&#41;&#46; Shapiro&#8211;Wilk normality test stated that gelsolin data followed a normal distribution&#46; Hence&#44; values were presented as means and standard deviation &#40;SD&#41;&#46; Comparison of means of quantitative variables between groups were made applying Student&#39;s <span class="elsevierStyleItalic">t</span> test&#46; Correlation of gelsolin levels with other variables was assessed by Pearson&#39;s correlation coefficient&#46; Statistical significance was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; Statistical analyses were performed using SPSS V20 software &#40;IBM Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinical characteristics are recorded in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Death in the 6 non-survivors patients occurred at mean day 44 &#40;range 21&#46;75&#8211;68&#46;50&#41;&#46; All deaths were direct effect of the SAH&#46; No patient suffered hydrocephalus during the studied period&#46; aSAH patients&#8217; gelsolin serum levels at admission were significantly increased &#40;23&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;42<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; compared with healthy control subjects &#40;16&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;89<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#41;&#46; In reference to the 48-hour sample&#44; gelsolin levels significantly decreased with respect to admission sample &#40;17&#46;80<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;14<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; When we grouped patients according to 6-month mortality&#44; we found a significant difference between controls and admission samples from deceased &#40;23&#46;81<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;24<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;021&#41; and between controls and survivors &#40;23&#46;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;4<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;036&#41;&#46; The present data showed no difference on gelsolin values between survivors and non-survivors&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Correlation analysis demonstrated the existence of significant correlation between gelsolin serum levels at 48<span class="elsevierStyleHsp" style=""></span>h of the bleeding and two severity scales&#58; negative correlation with the GCS score &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;597&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#41; and positive correlation with HH scale &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;554&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;032&#41;&#46; Gelsolin values did not vary according to the development of rebleeding or the performance of neurosurgery within 48<span class="elsevierStyleHsp" style=""></span>h of the initial bleeding&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To the authors&#8217; knowledge&#44; just few studies have analyzed the role of gelsolin in aSAH&#46; Kulakowska et al&#46; measured gelsolin with two assays &#40;immunoblotting and &#64258;uorometric actin polymerization&#41; in cerebrospinal fluid &#40;CSF&#41; and serum from patients with different neurological disorders&#44; and found that patients recovering from SAH had lower gelsolin levels compared to the other neurological pathologies&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Few years later&#44; Chou et al&#46; analyzed gelsolin in 42 SAH patients&#44; reporting a decrease in blood gelsolin levels in SAH patients compared with controls&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Later&#44; Pan et al&#46; performed a study with the largest SAH population to date to analyze gelsoline role&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Similarly to previous findings&#44; authors concluded that blood gelsolin levels on admission from SAH patients were significantly lower compared to healthy controls&#46; Moreover&#44; they found a significant difference in gelsolin levels depending on 6-month GOS &#40;survivors vs&#46; deceased&#59; good vs&#46; poor outcome&#41;&#46; Their correlation analysis stated a negative correlation between gelsolin and WFNS and Fisher scores&#46; These results do not agree with the ones obtained in the present study&#46; Nevertheless we should highlight the differences on the assay employed to measure gelsolin&#46; Pan et al&#46; measured gelsolin in plasma&#44; using an enzyme-linked immunosorbent assay commercialized by CoTimes &#40;Beijing&#44; China&#41;&#46; While they referred a mean value for gelsolin in healthy subjects of 126&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; our results state 16&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;89<span class="elsevierStyleHsp" style=""></span>pg&#47;mL for controls&#46; This difference rounds 5 orders of magnitude&#44; hence it should be necessary to analyze concordance and correlation between both gelsolin assays before comparing these studies results&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Additionally&#44; we measured gelsolin in serum&#44; not in plasma&#46; Besides&#44; previous to compare biochemical results from the diverse studies&#44; we should also consider differences on the recruited population&#44; based on the SAH severity degree according to the clinical scales&#46; Thus&#44; Chou et al&#46; study had almost 70&#37; SAH patients with I&#8211;III HH score&#44; while in the present work just 40&#37; SAH patients had I&#8211;III HH grade&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Studies performed in animal models have suggested that gelsolin has a neuroprotective role&#44; correlating its concentration to the cerebral infarct size&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In an attempt to explain the differences between our results and the previously published concerning gelsolin levels in SAH patients&#44; we hypothesize that the increase in gelsolin levels that we observe at admission is a reply of the organism to the primary damage&#44; in an attempt to increase the gelsolin blood pool to scavenge and neutralize circulating actin and lipopolysaccharide that would exacerbate the pro-inflammatory response&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> In reference to our correlation results&#44; we observe that higher gelsolin concentration is associated with lower GCS score and with higher HH classification&#44; that is&#44; the most severe the aSAH patients is&#44; the higher gelsolin concentration&#46; These results agree with the fact that aSAH patients had higher gelsolin levels than healthy controls&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; our preliminary results indicate that&#44; gelsolin serum levels increase at the moment of the bleeding in patients suffering aSAH and decrease within 48<span class="elsevierStyleHsp" style=""></span>h&#44; reaching healthy control levels&#46; Moreover&#44; 48-hour gelsolin serum concentration correlates with aSAH patient severity&#46; We consider it would be of great interest to enlarge the sample size and the follow-up period to analyze the potential role of gelsolin as predictor of aSAH main complications &#40;cerebral vasospasm and delayed cerebral ischemia&#41; as well as patients&#8217; outcome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study was funded by a grant from Consejer&#237;a de Igualdad&#44; Salud y Pol&#237;ticas Sociales de Andaluc&#237;a&#44; Spain &#40;PI-0136-2012&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare no conflicting interest in this work&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gelsolin serum levels &#40;pg&#47;mL&#41; from healthy controls and aneurismal subarachnoid hemorrhage &#40;aSAH&#41; patients&#46; Bars<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>mean gelsolin level&#59; error bar<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; &#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">aSAH patients<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gender&#44; male&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age&#44; median &#40;IQR&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56 &#40;50&#8211;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;44&#46;00&#8211;58&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;50 &#40;56&#46;25&#8211;65&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">GCS score&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;53&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>9&#8211;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">HH&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;26&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">WFNS&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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Scientific Letter
Serum gelsolin levels in aneurismal subarachnoid hemorrhage: Preliminary results
Niveles séricos de gelsolina en pacientes con hemorragia subaracnoidea de origen aneurismático: resultados preliminares
A. Rodríguez-Rodrígueza,
Corresponding author
, J.J. Egea-Guerreroa, Z. Ruiz de Azúa-Lópeza, G. Rivera-Rubialesa, Á. Vilches-Arenasb, F. Murillo-Cabezasa
a Cuidados Críticos, Hospital Universitario Virgen del Rocío, IBIS/CSIC/Universidad de Sevilla, Spain
b Servicio de Medicina Preventiva y Salud Pública,Hospital Virgen Macarena, Universidad de Sevilla, Spain
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describe its kinetic within 48<span class="elsevierStyleHsp" style=""></span>h post-bleeding and assess its role as a possible outcome predictor&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">For this purpose&#44; we included patients admitted to the NeuroCritical Care Unit &#40;NCCU&#41; at Virgen del Roc&#237;o University Hospital in Seville&#44; Spain&#44; with the diagnosis of aSAH during a 5-month long period&#46; The protocol&#44; carried out in accordance with the Declaration of Helsinki&#44; was approved by our hospital Institution Review Board&#46; Written informed consent was obtained from patients family members&#46; aSAH were eligible based on the following inclusion criteria&#58; aged 18 or over&#44; clinical history of SAH with evidence of bleeding on CT scan&#44; NCCU admission within 24<span class="elsevierStyleHsp" style=""></span>h of onset&#44; absence of tumor&#44; trauma&#44; previous episodes of SAH or any other neurological disease that could modify results&#46; 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Comparison of means of quantitative variables between groups were made applying Student&#39;s <span class="elsevierStyleItalic">t</span> test&#46; Correlation of gelsolin levels with other variables was assessed by Pearson&#39;s correlation coefficient&#46; Statistical significance was defined as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; Statistical analyses were performed using SPSS V20 software &#40;IBM Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinical characteristics are recorded in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Death in the 6 non-survivors patients occurred at mean day 44 &#40;range 21&#46;75&#8211;68&#46;50&#41;&#46; All deaths were direct effect of the SAH&#46; No patient suffered hydrocephalus during the studied period&#46; aSAH patients&#8217; gelsolin serum levels at admission were significantly increased &#40;23&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;42<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; compared with healthy control subjects &#40;16&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;89<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#41;&#46; In reference to the 48-hour sample&#44; gelsolin levels significantly decreased with respect to admission sample &#40;17&#46;80<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;14<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;031&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; When we grouped patients according to 6-month mortality&#44; we found a significant difference between controls and admission samples from deceased &#40;23&#46;81<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;24<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;021&#41; and between controls and survivors &#40;23&#46;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;4<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;036&#41;&#46; The present data showed no difference on gelsolin values between survivors and non-survivors&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Correlation analysis demonstrated the existence of significant correlation between gelsolin serum levels at 48<span class="elsevierStyleHsp" style=""></span>h of the bleeding and two severity scales&#58; negative correlation with the GCS score &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;597&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#41; and positive correlation with HH scale &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;554&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;032&#41;&#46; Gelsolin values did not vary according to the development of rebleeding or the performance of neurosurgery within 48<span class="elsevierStyleHsp" style=""></span>h of the initial bleeding&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To the authors&#8217; knowledge&#44; just few studies have analyzed the role of gelsolin in aSAH&#46; Kulakowska et al&#46; measured gelsolin with two assays &#40;immunoblotting and &#64258;uorometric actin polymerization&#41; in cerebrospinal fluid &#40;CSF&#41; and serum from patients with different neurological disorders&#44; and found that patients recovering from SAH had lower gelsolin levels compared to the other neurological pathologies&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Few years later&#44; Chou et al&#46; analyzed gelsolin in 42 SAH patients&#44; reporting a decrease in blood gelsolin levels in SAH patients compared with controls&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Later&#44; Pan et al&#46; performed a study with the largest SAH population to date to analyze gelsoline role&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Similarly to previous findings&#44; authors concluded that blood gelsolin levels on admission from SAH patients were significantly lower compared to healthy controls&#46; Moreover&#44; they found a significant difference in gelsolin levels depending on 6-month GOS &#40;survivors vs&#46; deceased&#59; good vs&#46; poor outcome&#41;&#46; Their correlation analysis stated a negative correlation between gelsolin and WFNS and Fisher scores&#46; These results do not agree with the ones obtained in the present study&#46; Nevertheless we should highlight the differences on the assay employed to measure gelsolin&#46; Pan et al&#46; measured gelsolin in plasma&#44; using an enzyme-linked immunosorbent assay commercialized by CoTimes &#40;Beijing&#44; China&#41;&#46; While they referred a mean value for gelsolin in healthy subjects of 126&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; our results state 16&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;89<span class="elsevierStyleHsp" style=""></span>pg&#47;mL for controls&#46; This difference rounds 5 orders of magnitude&#44; hence it should be necessary to analyze concordance and correlation between both gelsolin assays before comparing these studies results&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Additionally&#44; we measured gelsolin in serum&#44; not in plasma&#46; Besides&#44; previous to compare biochemical results from the diverse studies&#44; we should also consider differences on the recruited population&#44; based on the SAH severity degree according to the clinical scales&#46; Thus&#44; Chou et al&#46; study had almost 70&#37; SAH patients with I&#8211;III HH score&#44; while in the present work just 40&#37; SAH patients had I&#8211;III HH grade&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Studies performed in animal models have suggested that gelsolin has a neuroprotective role&#44; correlating its concentration to the cerebral infarct size&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In an attempt to explain the differences between our results and the previously published concerning gelsolin levels in SAH patients&#44; we hypothesize that the increase in gelsolin levels that we observe at admission is a reply of the organism to the primary damage&#44; in an attempt to increase the gelsolin blood pool to scavenge and neutralize circulating actin and lipopolysaccharide that would exacerbate the pro-inflammatory response&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> In reference to our correlation results&#44; we observe that higher gelsolin concentration is associated with lower GCS score and with higher HH classification&#44; that is&#44; the most severe the aSAH patients is&#44; the higher gelsolin concentration&#46; These results agree with the fact that aSAH patients had higher gelsolin levels than healthy controls&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion&#44; our preliminary results indicate that&#44; gelsolin serum levels increase at the moment of the bleeding in patients suffering aSAH and decrease within 48<span class="elsevierStyleHsp" style=""></span>h&#44; reaching healthy control levels&#46; Moreover&#44; 48-hour gelsolin serum concentration correlates with aSAH patient severity&#46; We consider it would be of great interest to enlarge the sample size and the follow-up period to analyze the potential role of gelsolin as predictor of aSAH main complications &#40;cerebral vasospasm and delayed cerebral ischemia&#41; as well as patients&#8217; outcome&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study was funded by a grant from Consejer&#237;a de Igualdad&#44; Salud y Pol&#237;ticas Sociales de Andaluc&#237;a&#44; Spain &#40;PI-0136-2012&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare no conflicting interest in this work&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Gelsolin serum levels &#40;pg&#47;mL&#41; from healthy controls and aneurismal subarachnoid hemorrhage &#40;aSAH&#41; patients&#46; Bars<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>mean gelsolin level&#59; error bar<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; &#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">aSAH patients<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survivors<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-survivors<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gender&#44; male&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age&#44; median &#40;IQR&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56 &#40;50&#8211;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;44&#46;00&#8211;58&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;50 &#40;56&#46;25&#8211;65&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">GCS score&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;53&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>9&#8211;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">HH&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;26&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;46&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">WFNS&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;40&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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