array:24 [
  "pii" => "S2173572718301723"
  "issn" => "21735727"
  "doi" => "10.1016/j.medine.2018.09.002"
  "estado" => "S300"
  "fechaPublicacion" => "2018-12-01"
  "aid" => "1207"
  "copyright" => "Elsevier España, S.L.U. and SEMICYUC"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Intensiva. 2018;42:561-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 648
    "formatos" => array:3 [
      "EPUB" => 147
      "HTML" => 259
      "PDF" => 242
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210569118301232"
      "issn" => "02105691"
      "doi" => "10.1016/j.medin.2018.03.009"
      "estado" => "S300"
      "fechaPublicacion" => "2018-12-01"
      "aid" => "1207"
      "copyright" => "Elsevier España, S.L.U. y SEMICYUC"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Med Intensiva. 2018;42:561-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1022
        "formatos" => array:3 [
          "EPUB" => 168
          "HTML" => 439
          "PDF" => 415
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICA</span>"
        "titulo" => "Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "561"
            "paginaFinal" => "563"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Mortality and adequacy of therapeutic effort in a tertiary pediatric intensive care department&#58; An 11-year review"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1418
                "Ancho" => 2326
                "Tamanyo" => 278792
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortalidad por grupos y actitud al final de vida en el periodo de estudio&#46; Se describen con l&#237;neas continuas y de arriba hacia abajo&#58; la mortalidad total&#44; los pacientes en los que no se indica adecuaci&#243;n y los pacientes con adecuaci&#243;n del esfuerzo terap&#233;utico&#46; En l&#237;nea discontinua se observan los pacientes en los que no consta la actitud al final de vida&#46; En las diferentes barras de frecuencias se observa de izquierda a derecha en cada a&#241;o&#58; pacientes sanos&#44; oncohematol&#243;gicos&#44; neurol&#243;gicos&#44; respiratorios e incluidos en el grupo &#8220;otros&#8221;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Leoz Gordillo, A&#46; Garc&#237;a-Salido, C&#46; Ni&#241;o Taravilla, G&#46; de Lama Caro-Pat&#243;n, M&#46;I&#46; Iglesias Bouzas, A&#46; Serrano Gonz&#225;lez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Leoz Gordillo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Garc&#237;a-Salido"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ni&#241;o Taravilla"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "de Lama Caro-Pat&#243;n"
              ]
              4 => array:2 [
                "nombre" => "M&#46;I&#46;"
                "apellidos" => "Iglesias Bouzas"
              ]
              5 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Serrano Gonz&#225;lez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173572718301723"
          "doi" => "10.1016/j.medine.2018.09.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301723?idApp=WMIE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301232?idApp=WMIE"
      "url" => "/02105691/0000004200000009/v1_201811220619/S0210569118301232/v1_201811220619/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173572718301747"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2018.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-12-01"
    "aid" => "1226"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2018;42:563-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 744
      "formatos" => array:3 [
        "EPUB" => 144
        "HTML" => 380
        "PDF" => 220
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Clinical repercussion of early cardiovascular events appearance in critically ill patients in mechanical ventilation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "563"
          "paginaFinal" => "566"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Repercusi&#243;n cl&#237;nica de la aparici&#243;n de eventos cardiovasculares precoces en pacientes cr&#237;ticos en ventilaci&#243;n mec&#225;nica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1751
              "Ancho" => 2083
              "Tamanyo" => 95192
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Survival curve of patients with and without early cardiovascular events&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Ortega-S&#225;ez, J&#46;B&#46; L&#243;pez-Messa, B&#46; Rom&#225;n-Garc&#237;a, F&#46;J&#46; Manuel-Merino, J&#46; Andr&#233;s-de-Llano, S&#46; Moradillo-Gonz&#225;lez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ortega-S&#225;ez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;B&#46;"
              "apellidos" => "L&#243;pez-Messa"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Rom&#225;n-Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Manuel-Merino"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Andr&#233;s-de-Llano"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Moradillo-Gonz&#225;lez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569118301657"
        "doi" => "10.1016/j.medin.2018.06.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301657?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301747?idApp=WMIE"
    "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301747/v1_201811250605/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173572718301863"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2018.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-12-01"
    "aid" => "1204"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2018;42:558-61"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 636
      "formatos" => array:3 [
        "EPUB" => 157
        "HTML" => 257
        "PDF" => 222
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Life-support treatments at end of life&#58; Costs and ethical aspects&#46; Point of view in an intensive care unit based on Q methodology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "558"
          "paginaFinal" => "561"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamientos de soporte vital al final de la vida&#58; costos y aspectos &#233;ticos&#46; Punto de vista en una unidad de cuidados intensivos basado en la metodolog&#237;a Q"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Jim&#233;nez Alfonso, P&#46; Escudero Acha, M&#46; Ortiz-Lasa, E&#46; Chicote, T&#46; Dierssen-Soto, A&#46; Gonz&#225;lez-Castro"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jim&#233;nez Alfonso"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Escudero Acha"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ortiz-Lasa"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Chicote"
            ]
            4 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Dierssen-Soto"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez-Castro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569118301207"
        "doi" => "10.1016/j.medin.2018.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301207?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301863?idApp=WMIE"
    "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301863/v1_201811250605/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Mortality and adequacy of therapeutic effort in a tertiary pediatric intensive care department&#58; An 11-year review"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "561"
        "paginaFinal" => "563"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; Leoz Gordillo, A&#46; Garc&#237;a-Salido, C&#46; Ni&#241;o Taravilla, G&#46; de Lama Caro-Pat&#243;n, M&#46;I&#46; Iglesias Bouzas, A&#46; Serrano Gonz&#225;lez"
        "autores" => array:6 [
          0 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Leoz Gordillo"
          ]
          1 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Garc&#237;a-Salido"
            "email" => array:1 [
              0 => "citopensis&#64;yahoo&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ni&#241;o Taravilla"
          ]
          3 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "de Lama Caro-Pat&#243;n"
          ]
          4 => array:2 [
            "nombre" => "M&#46;I&#46;"
            "apellidos" => "Iglesias Bouzas"
          ]
          5 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Serrano Gonz&#225;lez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Cuidados Intensivos Pedi&#225;tricos&#44; Hospital Infantil Universitario Ni&#241;o Jes&#250;s&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1917
            "Ancho" => 3167
            "Tamanyo" => 419249
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortality per groups and end-of-life approach in the study period&#46; The straight lines from up to bottom represent overall mortality&#44; patients where the ATE remained unreported&#44; and patients were the ATE was actually reported&#46; The dotted lines represent patients were the end-of-life approach remained unreported&#46; The different frequency bars show&#44; from left to right&#44; and per year&#58; health patients&#44; hemato-oncological patients&#44; neurological patients&#44; respiratory patients&#44; and patients included in the group &#8220;other&#8221;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the context of the critically ill child&#44; the decisions that have to do with the adequacy of therapeutic effort &#40;ATE&#41; are&#44; at the same time&#44; cause for debate and reason for clinical interest&#46; This is particularly the case in situations where the expected improvement has not occurred and technology is key for life support purposes&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a> At present&#44; the medical literature that describes end-of-life care in pediatric intensive care units &#40;PICU&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> is scarce&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We hereby present a study that describes the characteristics of patients who have died in our PICU during the last decade&#46; It is an observational retrospective study conducted after obtaining the approval from the clinical research ethics committee&#46; The clinical reports of whose patients who died in the PICU from January 1 2006 through December 31 2016 were reviewed&#46; The variables collected were&#58; epidemiological&#44; presence of underlying disease prior to PICU admission&#44; cause for admission&#44; care received &#40;hemodynamic&#44; respiratory&#44; renal&#44; antimicrobial&#44; hematological and nutritional&#41;&#44; main cause of death&#44; days of stay at the PICU&#44; day of admission&#44; and adaptation of life support &#40;cause&#44; referral activity&#44; and participation of the family in end-of-life care&#41;&#46; A descriptive analysis of the answers was conducted using the SPSS<span class="elsevierStyleSup">&#174;</span> 19&#46;0 software for Windows&#46; Qualitative data were expressed as absolute frequencies and percentages&#44; and quantitative data as means and interquartile ranges or as means and standard deviations based on the characteristics of the variable under analysis&#46; In cases where one comparative analysis was conducted&#44; qualitative data were compared using the chi-square test&#46; <span class="elsevierStyleItalic">p</span> values &#60;0&#46;05 were considered statistically significant&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">9049 children were reviewed of which 151 &#40;1&#46;7&#37;&#41; died&#59; 147 patients &#40;77 boys&#47;70 girls&#41; with an average age of 6&#46;3 years old &#40;IQR 0&#46;05&#8211;21 years old&#41; were included in the study&#46; There were&#44; on average&#44; 13&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4 deaths per year&#46; Seventy-eight &#40;78&#41; out of the 147 patients had hemato-oncological conditions&#46; Of the total number of patients with hemato-oncological conditions who died&#44; 56&#47;78 received one hematopoietic progenitor-cell transplantation &#40;HPCT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Thirty-six &#40;36&#41; patients did not have a clinically significant disease &#40;24&#46;5&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The most common cause for admission was respiratory failure &#40;55&#47;147&#41; followed by sepsis&#47;serious infection &#40;35&#47;147&#41;&#46; Patients without a personal clinical history were admitted to the PICU following severe trauma &#40;11&#47;36&#41; and septic shock &#40;7&#47;36&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Hemodynamic support was used in 117&#47;147 patients&#46; In 45&#47;147 patients non-invasive mechanical ventilation was required&#44; while 138&#47;147 patients required invasive mechanical ventilation&#59; 70&#47;147 patients suffered renal failure being extra-renal depuration required in 34&#47;70 patients&#59; 115&#47;147 patients required transfusion of hemoderivatives and 60&#47;136 patients parenteral nutrition&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The most common cause of death was refractory hypoxemia &#40;51&#47;146&#59; in one patient the main cause for death was not reported&#41; followed by sepsis &#40;31&#47;146&#41; and brain death &#40;31&#47;146&#41;&#46; In patients without a significant clinical history&#44; brain death was the main cause of death &#40;18&#47;36&#41;&#59; among the patients with hemato-oncological disease &#40;43&#47;78&#41; the main cause of death was refractory hypoxemia&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">When it comes to the ATE&#44; in 88 out of the 147 patients&#44; this remained unexplained&#46; The most common cause of death in the group without ATE was brain death &#40;31&#47;88&#41; followed by sepsis&#47;septic shock &#40;26&#47;88&#41;&#46; In 41&#47;59 of the remaining patients a report was given on the ATE as well as on why and what measures implemented&#46; Twenty-seven &#40;27&#41; patients had hemato-oncological conditions being refractory hypoxemia the disease these measures were more commonly implemented against &#40;22&#47;41&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Only in 2 out of the 75 patients who died due to acute or sudden disease life support adequacy measures were implemented&#46; Only in one patient without an underlying prior disease ATE measures were implemented&#46; The ATE measures were more commonly implemented following hemodynamic instability &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#44; need for mechanical ventilation &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#44; renal failure &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; parenteral nutrition &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and transfusions of hemoderivatives &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patients whose ATE was reported had longer hospital stays &#40;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17 days versus 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;7 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; The reason why the ATE was implemented had to do with both the irreversibility of the disease that prompted the PICU admission &#40;in 18 out of 41 patients&#41; and the poor prognosis of the underlying disease &#40;in 12 out of 41 patients&#41;&#46; Both the hemodynamic and the ventilatory support were withdrawn in 8&#47;41 patients&#46; Measures focused on well-being&#44; sedation and analgesia were a priority in 7&#47;41 patients&#46; It was decided not to implement any new extraordinary measures in 6&#47;41 patients and in 4&#47;41 patients any pharmacological therapy not aimed at improving the patient&#39;s well-being was withdrawn&#46; In 16 patients&#44; the therapeutic remains unknown&#46; The family was informed at all time and involved in the decision-making process in 29&#47;41 patients&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In the series provided more than half of the patients who died suffered from hemato-oncological disease&#46; In these&#44; the HPCT was a prior common event&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> In turn&#44; the ATE is often reported in patients with a prior condition and it would determine their prognosis prior to their referral to the PICU&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This decision was barely reported in healthy children or in severe and acute processes with a quick resolution&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The ATE was associated with longer hospital stays&#46; Although we do not mean to say that in order to consider the ATE it was required that a &#8220;certain amount of time&#8221; would need to pass&#44; it does seem that this aspect was key in the decision-making process&#46; Refractory hypoxemia was the main cause of death in the group of patients where the ATE was reported&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> Parents and caregivers were included in more than half the cases of ATE&#46; It is well known that its perspective influences the therapeutic goal and defines well-being as a priority&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">This study has some limitations though&#46; Except for epidemiological data&#44; the remaining data were not collected thoroughly&#46; They do not even include information on severity assessment scales at admission and in 4 patients no variable could be collected for the study&#46; It would certainly be interesting to collect prospective and multicenter data with the exact time and moment when each change is implemented in the decision-making process&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In sum&#44; given the specific conditions of our center&#44; patients with onco-hematological conditions and&#44; in particular&#44; those with a prior history of HPCT are the main group of patients where the ATE was reported&#46; Mainly&#44; it was associated with long hospital stays&#44; being the inotropic drug and ventilatory support withdrawal the most common measures implemented&#46; We hope that this study will revitalize the debate and increase our actual knowledge on the ATE in the PICUs of our country&#46; The creation of a national registry on this regard not only seems interesting but necessary&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Leoz Gordillo I&#44; Garc&#237;a-Salido A&#44; Ni&#241;o Taravilla C&#44; de Lama Caro-Pat&#243;n G&#44; Iglesias Bouzas MI&#44; Serrano Gonz&#225;lez A&#46; Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os&#46; Med Intensiva&#46; 2018&#59;42&#58;561&#8211;563&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1917
            "Ancho" => 3167
            "Tamanyo" => 419249
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortality per groups and end-of-life approach in the study period&#46; The straight lines from up to bottom represent overall mortality&#44; patients where the ATE remained unreported&#44; and patients were the ATE was actually reported&#46; The dotted lines represent patients were the end-of-life approach remained unreported&#46; The different frequency bars show&#44; from left to right&#44; and per year&#58; health patients&#44; hemato-oncological patients&#44; neurological patients&#44; respiratory patients&#44; and patients included in the group &#8220;other&#8221;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Withdrawal of assisted ventilation in the home&#58; making decisions in paediatric palliative care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garcia-Salido"
                            1 => "M&#46; Monleon-Luque"
                            2 => "M&#46; Barcelo-Escario"
                            3 => "C&#46; del Rincon-Fernandez"
                            4 => "E&#46; Cata-del Palacio"
                            5 => "R&#46; Martino-Alba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2014"
                        "volumen" => "80"
                        "paginaInicial" => "181"
                        "paginaFinal" => "183"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "End-of-life practices among tertiary care PICUs in the United States&#58; a multicenter study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;L&#46; Meert"
                            1 => "L&#46; Keele"
                            2 => "W&#46; Morrison"
                            3 => "R&#46;A&#46; Berg"
                            4 => "H&#46; Dalton"
                            5 => "C&#46;J&#46; Newth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PCC.0000000000000520"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Crit Care Med"
                        "fecha" => "2015"
                        "volumen" => "16"
                        "paginaInicial" => "e231"
                        "paginaFinal" => "e238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26335128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retrospective study of children referred from paediatric intensive care to palliative care&#58; why and for what"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garcia-Salido"
                            1 => "P&#46; Santos-Herranz"
                            2 => "V&#46; Puertas-Martin"
                            3 => "M&#46;A&#46; Garcia-Teresa"
                            4 => "R&#46; Martino-Alba"
                            5 => "A&#46; Serrano-Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2018"
                        "volumen" => "88"
                        "paginaInicial" => "3"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Withholding or withdrawing life-sustaining treatments&#58; an 8-yr retrospective review in a Spanish pediatric intensive care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Launes"
                            1 => "F&#46;J&#46; Cambra"
                            2 => "I&#46; Jordan"
                            3 => "A&#46; Palomeque"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PCC.0b013e31820aba5b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Crit Care Med"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "e383"
                        "paginaFinal" => "e385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21263365"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of death in the PICU at five U&#46;S&#46; teaching hospitals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Burns"
                            1 => "D&#46;E&#46; Sellers"
                            2 => "E&#46;C&#46; Meyer"
                            3 => "M&#46; Lewis-Newby"
                            4 => "R&#46;D&#46; Truog"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0000000000000498"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2014"
                        "volumen" => "42"
                        "paginaInicial" => "2101"
                        "paginaFinal" => "2108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24979486"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intensive Care Unit admissions among children after hematopoietic stem cell transplantation&#58; incidence&#44; outcome&#44; and prognostic factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Fernandez-Garcia"
                            1 => "M&#46; Gonzalez-Vicent"
                            2 => "I&#46; Mastro-Martinez"
                            3 => "A&#46; Serrano"
                            4 => "M&#46;A&#46; Diaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPH.0000000000000401"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Hematol Oncol"
                        "fecha" => "2015"
                        "volumen" => "37"
                        "paginaInicial" => "529"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26241722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "End-of-life care in the pediatric intensive care unit&#46; A literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Casanueva Mateos"
                            1 => "P&#46; Ruiz Lopez"
                            2 => "J&#46;I&#46; Sanchez Diaz"
                            3 => "M&#46;V&#46; Ramos Casado"
                            4 => "S&#46; Belda Hofheinz"
                            5 => "A&#46; Llorente de la Fuente"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2005"
                        "volumen" => "63"
                        "paginaInicial" => "152"
                        "paginaFinal" => "159"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301723/v1_201811250605/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "15647"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000004200000009/v1_201811250605/S2173572718301723/v1_201811250605/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301723?idApp=WMIE"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific Letter
Mortality and adequacy of therapeutic effort in a tertiary pediatric intensive care department: An 11-year review
Mortalidad y adecuación del esfuerzo terapéutico en un servicio terciario de cuidados intensivos pediátricos: revisión de 11 años
I. Leoz Gordillo, A. García-Salido
Corresponding author
citopensis@yahoo.es

Corresponding author.
, C. Niño Taravilla, G. de Lama Caro-Patón, M.I. Iglesias Bouzas, A. Serrano González
Servicio de Cuidados Intensivos Pediátricos, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
Read
4048
Times
was read the article
1989
Total PDF
2059
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173572718301723"
  "issn" => "21735727"
  "doi" => "10.1016/j.medine.2018.09.002"
  "estado" => "S300"
  "fechaPublicacion" => "2018-12-01"
  "aid" => "1207"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Intensiva. 2018;42:561-3"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 648
    "formatos" => array:3 [
      "EPUB" => 147
      "HTML" => 259
      "PDF" => 242
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210569118301232"
      "issn" => "02105691"
      "doi" => "10.1016/j.medin.2018.03.009"
      "estado" => "S300"
      "fechaPublicacion" => "2018-12-01"
      "aid" => "1207"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y SEMICYUC"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Med Intensiva. 2018;42:561-3"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1022
        "formatos" => array:3 [
          "EPUB" => 168
          "HTML" => 439
          "PDF" => 415
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICA</span>"
        "titulo" => "Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "561"
            "paginaFinal" => "563"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Mortality and adequacy of therapeutic effort in a tertiary pediatric intensive care department&#58; An 11-year review"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1418
                "Ancho" => 2326
                "Tamanyo" => 278792
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortalidad por grupos y actitud al final de vida en el periodo de estudio&#46; Se describen con l&#237;neas continuas y de arriba hacia abajo&#58; la mortalidad total&#44; los pacientes en los que no se indica adecuaci&#243;n y los pacientes con adecuaci&#243;n del esfuerzo terap&#233;utico&#46; En l&#237;nea discontinua se observan los pacientes en los que no consta la actitud al final de vida&#46; En las diferentes barras de frecuencias se observa de izquierda a derecha en cada a&#241;o&#58; pacientes sanos&#44; oncohematol&#243;gicos&#44; neurol&#243;gicos&#44; respiratorios e incluidos en el grupo &#8220;otros&#8221;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Leoz Gordillo, A&#46; Garc&#237;a-Salido, C&#46; Ni&#241;o Taravilla, G&#46; de Lama Caro-Pat&#243;n, M&#46;I&#46; Iglesias Bouzas, A&#46; Serrano Gonz&#225;lez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Leoz Gordillo"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Garc&#237;a-Salido"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Ni&#241;o Taravilla"
              ]
              3 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "de Lama Caro-Pat&#243;n"
              ]
              4 => array:2 [
                "nombre" => "M&#46;I&#46;"
                "apellidos" => "Iglesias Bouzas"
              ]
              5 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Serrano Gonz&#225;lez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173572718301723"
          "doi" => "10.1016/j.medine.2018.09.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301723?idApp=WMIE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301232?idApp=WMIE"
      "url" => "/02105691/0000004200000009/v1_201811220619/S0210569118301232/v1_201811220619/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173572718301747"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2018.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-12-01"
    "aid" => "1226"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2018;42:563-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 744
      "formatos" => array:3 [
        "EPUB" => 144
        "HTML" => 380
        "PDF" => 220
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Clinical repercussion of early cardiovascular events appearance in critically ill patients in mechanical ventilation"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "563"
          "paginaFinal" => "566"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Repercusi&#243;n cl&#237;nica de la aparici&#243;n de eventos cardiovasculares precoces en pacientes cr&#237;ticos en ventilaci&#243;n mec&#225;nica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1751
              "Ancho" => 2083
              "Tamanyo" => 95192
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Survival curve of patients with and without early cardiovascular events&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Ortega-S&#225;ez, J&#46;B&#46; L&#243;pez-Messa, B&#46; Rom&#225;n-Garc&#237;a, F&#46;J&#46; Manuel-Merino, J&#46; Andr&#233;s-de-Llano, S&#46; Moradillo-Gonz&#225;lez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ortega-S&#225;ez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;B&#46;"
              "apellidos" => "L&#243;pez-Messa"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Rom&#225;n-Garc&#237;a"
            ]
            3 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Manuel-Merino"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Andr&#233;s-de-Llano"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Moradillo-Gonz&#225;lez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569118301657"
        "doi" => "10.1016/j.medin.2018.06.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301657?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301747?idApp=WMIE"
    "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301747/v1_201811250605/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173572718301863"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2018.03.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-12-01"
    "aid" => "1204"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2018;42:558-61"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 636
      "formatos" => array:3 [
        "EPUB" => 157
        "HTML" => 257
        "PDF" => 222
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "Life-support treatments at end of life&#58; Costs and ethical aspects&#46; Point of view in an intensive care unit based on Q methodology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "558"
          "paginaFinal" => "561"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Tratamientos de soporte vital al final de la vida&#58; costos y aspectos &#233;ticos&#46; Punto de vista en una unidad de cuidados intensivos basado en la metodolog&#237;a Q"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Jim&#233;nez Alfonso, P&#46; Escudero Acha, M&#46; Ortiz-Lasa, E&#46; Chicote, T&#46; Dierssen-Soto, A&#46; Gonz&#225;lez-Castro"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jim&#233;nez Alfonso"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Escudero Acha"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ortiz-Lasa"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Chicote"
            ]
            4 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Dierssen-Soto"
            ]
            5 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez-Castro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569118301207"
        "doi" => "10.1016/j.medin.2018.03.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569118301207?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301863?idApp=WMIE"
    "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301863/v1_201811250605/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
    "titulo" => "Mortality and adequacy of therapeutic effort in a tertiary pediatric intensive care department&#58; An 11-year review"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "561"
        "paginaFinal" => "563"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; Leoz Gordillo, A&#46; Garc&#237;a-Salido, C&#46; Ni&#241;o Taravilla, G&#46; de Lama Caro-Pat&#243;n, M&#46;I&#46; Iglesias Bouzas, A&#46; Serrano Gonz&#225;lez"
        "autores" => array:6 [
          0 => array:2 [
            "nombre" => "I&#46;"
            "apellidos" => "Leoz Gordillo"
          ]
          1 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Garc&#237;a-Salido"
            "email" => array:1 [
              0 => "citopensis&#64;yahoo&#46;es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Ni&#241;o Taravilla"
          ]
          3 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "de Lama Caro-Pat&#243;n"
          ]
          4 => array:2 [
            "nombre" => "M&#46;I&#46;"
            "apellidos" => "Iglesias Bouzas"
          ]
          5 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Serrano Gonz&#225;lez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Cuidados Intensivos Pedi&#225;tricos&#44; Hospital Infantil Universitario Ni&#241;o Jes&#250;s&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1917
            "Ancho" => 3167
            "Tamanyo" => 419249
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortality per groups and end-of-life approach in the study period&#46; The straight lines from up to bottom represent overall mortality&#44; patients where the ATE remained unreported&#44; and patients were the ATE was actually reported&#46; The dotted lines represent patients were the end-of-life approach remained unreported&#46; The different frequency bars show&#44; from left to right&#44; and per year&#58; health patients&#44; hemato-oncological patients&#44; neurological patients&#44; respiratory patients&#44; and patients included in the group &#8220;other&#8221;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the context of the critically ill child&#44; the decisions that have to do with the adequacy of therapeutic effort &#40;ATE&#41; are&#44; at the same time&#44; cause for debate and reason for clinical interest&#46; This is particularly the case in situations where the expected improvement has not occurred and technology is key for life support purposes&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a> At present&#44; the medical literature that describes end-of-life care in pediatric intensive care units &#40;PICU&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> is scarce&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We hereby present a study that describes the characteristics of patients who have died in our PICU during the last decade&#46; It is an observational retrospective study conducted after obtaining the approval from the clinical research ethics committee&#46; The clinical reports of whose patients who died in the PICU from January 1 2006 through December 31 2016 were reviewed&#46; The variables collected were&#58; epidemiological&#44; presence of underlying disease prior to PICU admission&#44; cause for admission&#44; care received &#40;hemodynamic&#44; respiratory&#44; renal&#44; antimicrobial&#44; hematological and nutritional&#41;&#44; main cause of death&#44; days of stay at the PICU&#44; day of admission&#44; and adaptation of life support &#40;cause&#44; referral activity&#44; and participation of the family in end-of-life care&#41;&#46; A descriptive analysis of the answers was conducted using the SPSS<span class="elsevierStyleSup">&#174;</span> 19&#46;0 software for Windows&#46; Qualitative data were expressed as absolute frequencies and percentages&#44; and quantitative data as means and interquartile ranges or as means and standard deviations based on the characteristics of the variable under analysis&#46; In cases where one comparative analysis was conducted&#44; qualitative data were compared using the chi-square test&#46; <span class="elsevierStyleItalic">p</span> values &#60;0&#46;05 were considered statistically significant&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">9049 children were reviewed of which 151 &#40;1&#46;7&#37;&#41; died&#59; 147 patients &#40;77 boys&#47;70 girls&#41; with an average age of 6&#46;3 years old &#40;IQR 0&#46;05&#8211;21 years old&#41; were included in the study&#46; There were&#44; on average&#44; 13&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4 deaths per year&#46; Seventy-eight &#40;78&#41; out of the 147 patients had hemato-oncological conditions&#46; Of the total number of patients with hemato-oncological conditions who died&#44; 56&#47;78 received one hematopoietic progenitor-cell transplantation &#40;HPCT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Thirty-six &#40;36&#41; patients did not have a clinically significant disease &#40;24&#46;5&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The most common cause for admission was respiratory failure &#40;55&#47;147&#41; followed by sepsis&#47;serious infection &#40;35&#47;147&#41;&#46; Patients without a personal clinical history were admitted to the PICU following severe trauma &#40;11&#47;36&#41; and septic shock &#40;7&#47;36&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Hemodynamic support was used in 117&#47;147 patients&#46; In 45&#47;147 patients non-invasive mechanical ventilation was required&#44; while 138&#47;147 patients required invasive mechanical ventilation&#59; 70&#47;147 patients suffered renal failure being extra-renal depuration required in 34&#47;70 patients&#59; 115&#47;147 patients required transfusion of hemoderivatives and 60&#47;136 patients parenteral nutrition&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The most common cause of death was refractory hypoxemia &#40;51&#47;146&#59; in one patient the main cause for death was not reported&#41; followed by sepsis &#40;31&#47;146&#41; and brain death &#40;31&#47;146&#41;&#46; In patients without a significant clinical history&#44; brain death was the main cause of death &#40;18&#47;36&#41;&#59; among the patients with hemato-oncological disease &#40;43&#47;78&#41; the main cause of death was refractory hypoxemia&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">When it comes to the ATE&#44; in 88 out of the 147 patients&#44; this remained unexplained&#46; The most common cause of death in the group without ATE was brain death &#40;31&#47;88&#41; followed by sepsis&#47;septic shock &#40;26&#47;88&#41;&#46; In 41&#47;59 of the remaining patients a report was given on the ATE as well as on why and what measures implemented&#46; Twenty-seven &#40;27&#41; patients had hemato-oncological conditions being refractory hypoxemia the disease these measures were more commonly implemented against &#40;22&#47;41&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Only in 2 out of the 75 patients who died due to acute or sudden disease life support adequacy measures were implemented&#46; Only in one patient without an underlying prior disease ATE measures were implemented&#46; The ATE measures were more commonly implemented following hemodynamic instability &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#44; need for mechanical ventilation &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#44; renal failure &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; parenteral nutrition &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and transfusions of hemoderivatives &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patients whose ATE was reported had longer hospital stays &#40;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17 days versus 5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;7 days&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; The reason why the ATE was implemented had to do with both the irreversibility of the disease that prompted the PICU admission &#40;in 18 out of 41 patients&#41; and the poor prognosis of the underlying disease &#40;in 12 out of 41 patients&#41;&#46; Both the hemodynamic and the ventilatory support were withdrawn in 8&#47;41 patients&#46; Measures focused on well-being&#44; sedation and analgesia were a priority in 7&#47;41 patients&#46; It was decided not to implement any new extraordinary measures in 6&#47;41 patients and in 4&#47;41 patients any pharmacological therapy not aimed at improving the patient&#39;s well-being was withdrawn&#46; In 16 patients&#44; the therapeutic remains unknown&#46; The family was informed at all time and involved in the decision-making process in 29&#47;41 patients&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In the series provided more than half of the patients who died suffered from hemato-oncological disease&#46; In these&#44; the HPCT was a prior common event&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> In turn&#44; the ATE is often reported in patients with a prior condition and it would determine their prognosis prior to their referral to the PICU&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This decision was barely reported in healthy children or in severe and acute processes with a quick resolution&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The ATE was associated with longer hospital stays&#46; Although we do not mean to say that in order to consider the ATE it was required that a &#8220;certain amount of time&#8221; would need to pass&#44; it does seem that this aspect was key in the decision-making process&#46; Refractory hypoxemia was the main cause of death in the group of patients where the ATE was reported&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> Parents and caregivers were included in more than half the cases of ATE&#46; It is well known that its perspective influences the therapeutic goal and defines well-being as a priority&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;7</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">This study has some limitations though&#46; Except for epidemiological data&#44; the remaining data were not collected thoroughly&#46; They do not even include information on severity assessment scales at admission and in 4 patients no variable could be collected for the study&#46; It would certainly be interesting to collect prospective and multicenter data with the exact time and moment when each change is implemented in the decision-making process&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In sum&#44; given the specific conditions of our center&#44; patients with onco-hematological conditions and&#44; in particular&#44; those with a prior history of HPCT are the main group of patients where the ATE was reported&#46; Mainly&#44; it was associated with long hospital stays&#44; being the inotropic drug and ventilatory support withdrawal the most common measures implemented&#46; We hope that this study will revitalize the debate and increase our actual knowledge on the ATE in the PICUs of our country&#46; The creation of a national registry on this regard not only seems interesting but necessary&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Leoz Gordillo I&#44; Garc&#237;a-Salido A&#44; Ni&#241;o Taravilla C&#44; de Lama Caro-Pat&#243;n G&#44; Iglesias Bouzas MI&#44; Serrano Gonz&#225;lez A&#46; Mortalidad y adecuaci&#243;n del esfuerzo terap&#233;utico en un servicio terciario de cuidados intensivos pedi&#225;tricos&#58; revisi&#243;n de 11 a&#241;os&#46; Med Intensiva&#46; 2018&#59;42&#58;561&#8211;563&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1917
            "Ancho" => 3167
            "Tamanyo" => 419249
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mortality per groups and end-of-life approach in the study period&#46; The straight lines from up to bottom represent overall mortality&#44; patients where the ATE remained unreported&#44; and patients were the ATE was actually reported&#46; The dotted lines represent patients were the end-of-life approach remained unreported&#46; The different frequency bars show&#44; from left to right&#44; and per year&#58; health patients&#44; hemato-oncological patients&#44; neurological patients&#44; respiratory patients&#44; and patients included in the group &#8220;other&#8221;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Withdrawal of assisted ventilation in the home&#58; making decisions in paediatric palliative care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garcia-Salido"
                            1 => "M&#46; Monleon-Luque"
                            2 => "M&#46; Barcelo-Escario"
                            3 => "C&#46; del Rincon-Fernandez"
                            4 => "E&#46; Cata-del Palacio"
                            5 => "R&#46; Martino-Alba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2014"
                        "volumen" => "80"
                        "paginaInicial" => "181"
                        "paginaFinal" => "183"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "End-of-life practices among tertiary care PICUs in the United States&#58; a multicenter study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;L&#46; Meert"
                            1 => "L&#46; Keele"
                            2 => "W&#46; Morrison"
                            3 => "R&#46;A&#46; Berg"
                            4 => "H&#46; Dalton"
                            5 => "C&#46;J&#46; Newth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PCC.0000000000000520"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Crit Care Med"
                        "fecha" => "2015"
                        "volumen" => "16"
                        "paginaInicial" => "e231"
                        "paginaFinal" => "e238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26335128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retrospective study of children referred from paediatric intensive care to palliative care&#58; why and for what"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Garcia-Salido"
                            1 => "P&#46; Santos-Herranz"
                            2 => "V&#46; Puertas-Martin"
                            3 => "M&#46;A&#46; Garcia-Teresa"
                            4 => "R&#46; Martino-Alba"
                            5 => "A&#46; Serrano-Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2018"
                        "volumen" => "88"
                        "paginaInicial" => "3"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Withholding or withdrawing life-sustaining treatments&#58; an 8-yr retrospective review in a Spanish pediatric intensive care unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Launes"
                            1 => "F&#46;J&#46; Cambra"
                            2 => "I&#46; Jordan"
                            3 => "A&#46; Palomeque"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/PCC.0b013e31820aba5b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Crit Care Med"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "e383"
                        "paginaFinal" => "e385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21263365"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of death in the PICU at five U&#46;S&#46; teaching hospitals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Burns"
                            1 => "D&#46;E&#46; Sellers"
                            2 => "E&#46;C&#46; Meyer"
                            3 => "M&#46; Lewis-Newby"
                            4 => "R&#46;D&#46; Truog"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0000000000000498"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2014"
                        "volumen" => "42"
                        "paginaInicial" => "2101"
                        "paginaFinal" => "2108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24979486"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intensive Care Unit admissions among children after hematopoietic stem cell transplantation&#58; incidence&#44; outcome&#44; and prognostic factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Fernandez-Garcia"
                            1 => "M&#46; Gonzalez-Vicent"
                            2 => "I&#46; Mastro-Martinez"
                            3 => "A&#46; Serrano"
                            4 => "M&#46;A&#46; Diaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MPH.0000000000000401"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Hematol Oncol"
                        "fecha" => "2015"
                        "volumen" => "37"
                        "paginaInicial" => "529"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26241722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;in Spanish&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "End-of-life care in the pediatric intensive care unit&#46; A literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Casanueva Mateos"
                            1 => "P&#46; Ruiz Lopez"
                            2 => "J&#46;I&#46; Sanchez Diaz"
                            3 => "M&#46;V&#46; Ramos Casado"
                            4 => "S&#46; Belda Hofheinz"
                            5 => "A&#46; Llorente de la Fuente"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2005"
                        "volumen" => "63"
                        "paginaInicial" => "152"
                        "paginaFinal" => "159"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000004200000009/v1_201811250605/S2173572718301723/v1_201811250605/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "15647"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000004200000009/v1_201811250605/S2173572718301723/v1_201811250605/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572718301723?idApp=WMIE"
]
Article information
ISSN: 21735727
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 2 6 8
2024 October 44 40 84
2024 September 34 24 58
2024 August 53 39 92
2024 July 34 26 60
2024 June 42 48 90
2024 May 35 24 59
2024 April 50 32 82
2024 March 51 23 74
2024 February 38 41 79
2024 January 23 29 52
2023 December 29 37 66
2023 November 37 42 79
2023 October 29 27 56
2023 September 22 37 59
2023 August 20 28 48
2023 July 30 29 59
2023 June 27 19 46
2023 May 32 40 72
2023 April 37 19 56
2023 March 37 30 67
2023 February 30 31 61
2023 January 19 19 38
2022 December 46 30 76
2022 November 27 37 64
2022 October 50 40 90
2022 September 34 35 69
2022 August 43 44 87
2022 July 34 54 88
2022 June 73 25 98
2022 May 41 34 75
2022 April 24 31 55
2022 March 25 42 67
2022 February 20 22 42
2022 January 22 32 54
2021 December 30 47 77
2021 November 25 34 59
2021 October 40 75 115
2021 September 24 34 58
2021 August 15 37 52
2021 July 15 40 55
2021 June 27 24 51
2021 May 36 41 77
2021 April 68 65 133
2021 March 55 28 83
2021 February 41 23 64
2021 January 29 28 57
2020 December 31 16 47
2020 November 16 12 28
2020 October 32 25 57
2020 September 22 12 34
2020 August 16 15 31
2020 July 12 18 30
2020 June 19 14 33
2020 May 15 12 27
2020 April 20 15 35
2020 March 7 4 11
2020 February 35 37 72
2020 January 24 23 47
2019 December 22 20 42
2019 November 18 21 39
2019 October 23 16 39
2019 September 27 18 45
2019 August 30 24 54
2019 July 22 19 41
2019 June 21 10 31
2019 May 30 23 53
2019 April 13 19 32
2019 March 3 4 7
2019 February 0 5 5
2019 January 1 15 16
2018 December 1 0 1
Show all

Follow this link to access the full text of the article

Idiomas
Medicina Intensiva (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?