Scientific Letter
Human T lymphotropic virus (HTLV I and II) antibodies seroprevalence among organ donors
O. Leizaola Irigoyena,b,
, B. Leoz Gordilloa,b, S. Balboa Palominoa,b, M. Rodríguez Perezb,c, B. Mahillo Duránd, D. Escudero Augustoa,b
Corresponding author
a Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
b Grupo de Investigación en Microbiología Traslacional del Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain
c Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
d Organización Nacional de Trasplantes (ONT), Madrid, Spain
Read
5953
Timeswas read the article
1886
Total PDF
4067
Total HTML
Share statistics
array:24 [ "pii" => "S2173572719301729" "issn" => "21735727" "doi" => "10.1016/j.medine.2019.06.014" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "1360" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2020;44:451-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0210569119301755" "issn" => "02105691" "doi" => "10.1016/j.medin.2019.06.005" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "1360" "copyright" => "Elsevier España, S.L.U. y SEMICYUC" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2020;44:451-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 14 "formatos" => array:2 [ "HTML" => 7 "PDF" => 7 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENTÍFICA</span>" "titulo" => "Seroprevalencia de anticuerpos frente a virus linfotrópicos humanos (HTLV I y II) en donantes de órganos" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "451" "paginaFinal" => "453" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Human T lymphotropic virus (HTLV I and II) antibodies seroprevalence among organ donors" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1056 "Ancho" => 1386 "Tamanyo" => 56650 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Muertes encefálicas, donantes y seroprevalencia de HTLV (2014-2018).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O. Leizaola Irigoyen, B. Leoz Gordillo, S. Balboa Palomino, M. Rodríguez Perez, B. Mahillo Durán, D. Escudero Augusto" "autores" => array:6 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Leizaola Irigoyen" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Leoz Gordillo" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Balboa Palomino" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Rodríguez Perez" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Mahillo Durán" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Escudero Augusto" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173572719301729" "doi" => "10.1016/j.medine.2019.06.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572719301729?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569119301755?idApp=WMIE" "url" => "/02105691/0000004400000007/v2_202012010732/S0210569119301755/v2_202012010732/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173572719301778" "issn" => "21735727" "doi" => "10.1016/j.medine.2019.06.016" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "1362" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2020;44:453-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">SCIENTIFIC LETTER</span>" "titulo" => "Translation and cultural adaptation process to Spanish of the Preschool Confusion Assessment Method for the Intensive Care Unit" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "453" "paginaFinal" => "456" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Traducción y adaptación cultural al español del" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1774 "Ancho" => 2508 "Tamanyo" => 890398 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Instructions for applying the psCAM-ICU-S.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.I. Figueroa-Ramos, C.M. Arroyo-Novoa, R.L. García-DeJesús, C.S. Sepúlveda-Santiago, S.S. Solís-Báez, E.W. Ely, H. Smith" "autores" => array:7 [ 0 => array:2 [ "nombre" => "M.I." "apellidos" => "Figueroa-Ramos" ] 1 => array:2 [ "nombre" => "C.M." "apellidos" => "Arroyo-Novoa" ] 2 => array:2 [ "nombre" => "R.L." "apellidos" => "García-DeJesús" ] 3 => array:2 [ "nombre" => "C.S." "apellidos" => "Sepúlveda-Santiago" ] 4 => array:2 [ "nombre" => "S.S." "apellidos" => "Solís-Báez" ] 5 => array:2 [ "nombre" => "E.W." "apellidos" => "Ely" ] 6 => array:2 [ "nombre" => "H." "apellidos" => "Smith" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0210569119301779" "doi" => "10.1016/j.medin.2019.06.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569119301779?idApp=WMIE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572719301778?idApp=WMIE" "url" => "/21735727/0000004400000007/v1_202010040640/S2173572719301778/v1_202010040640/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173572720301570" "issn" => "21735727" "doi" => "10.1016/j.medine.2019.06.018" "estado" => "S300" "fechaPublicacion" => "2020-10-01" "aid" => "1359" "copyright" => "Elsevier España, S.L.U. and SEMICYUC" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Intensiva. 2020;44:449-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Double and multiple cycling in mechanical ventilation: Complex events with varying clinical effects" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "449" "paginaFinal" => "451" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Doble y múltiples ciclados en ventilación mecánica: eventos complejos con diferentes significado clínico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2276 "Ancho" => 2199 "Tamanyo" => 227565 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow dyssynchrony in volume-assist control ventilation with decelerating (a) and constant flow (b). Delivered flow is insufficient to meet the patient's demand, resulting in a strong inspiratory effort, reflected as a drop in airway pressure (Paw) (green arrows), lasting longer than ventilator inspiratory time, that triggers second and third mechanical inspirations (red arrows).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Aquino Esperanza, L. Sarlabous, C. de Haro, M. Batlle, R. Magrans, J. Lopez-Aguilar, R. Fernandez, L. Blanch" "autores" => array:8 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Aquino Esperanza" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Sarlabous" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "de Haro" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Batlle" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Magrans" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Lopez-Aguilar" ] 6 => array:2 [ "nombre" => "R." "apellidos" => "Fernandez" ] 7 => array:2 [ "nombre" => "L." "apellidos" => "Blanch" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572720301570?idApp=WMIE" "url" => "/21735727/0000004400000007/v1_202010040640/S2173572720301570/v1_202010040640/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Human T lymphotropic virus (HTLV I and II) antibodies seroprevalence among organ donors" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "451" "paginaFinal" => "453" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "O. Leizaola Irigoyen, B. Leoz Gordillo, S. Balboa Palomino, M. Rodríguez Perez, B. Mahillo Durán, D. Escudero Augusto" "autores" => array:6 [ 0 => array:4 [ "nombre" => "O." "apellidos" => "Leizaola Irigoyen" "email" => array:1 [ 0 => "lei@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Leoz Gordillo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Balboa Palomino" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Rodríguez Perez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "B." "apellidos" => "Mahillo Durán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "D." "apellidos" => "Escudero Augusto" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Grupo de Investigación en Microbiología Traslacional del Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Organización Nacional de Trasplantes (ONT), Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1080 "Ancho" => 1386 "Tamanyo" => 55046 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain deaths, donors, and seroprevalence of HTLV (2014–2018).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">T lymphotropic viruses, types <span class="elsevierStyleSmallCaps">i</span> (HTLV-I) and <span class="elsevierStyleSmallCaps">ii</span> (HTLV-II) were the very first retroviruses ever identified in human beings. The HTLV-I virus causes tropical spastic paraparesis or HTLV-I-related myelopathy (degenerative neurological disease), T-cell leukemia in the adult, and other conditions like B-cell chronic lymphocytic leukemia, uveitis, arthritis, and dermatitis.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> The HTLV-II, however, has not been clearly associated with any diseases or conditions yet, but traditionally the screening microbiologic analysis always includes the HTLV I/II. Most HTLV-I-positive patients never develop clinical signs, yet high viral loads or immunosuppression due to HIV co-infection or immunosuppressant drugs may lead to developing the disease. These viruses are endemic in places like Japan, Sub-Saharan Africa, the Caribbean, and Central and South American where between 6% and 37% of all healthy adults over 40 are HIV-positive. Transmission happens through sexual intercourse, parenteral route, and mother-to-baby contact through breastfeeding. To categorize a geographical area as endemic, some authors suggest that the prevalence of HTLV-I in some populations should be between 1% and 5%.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The transmission of HTLV-I through blood transfusions has been reported in multiple studies and the screening for antibodies against HTLV I/II viruses is mandatory in the blood banks of several countries.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Nowadays in Spain and other countries, only the HTLV-I is screened to look for the presence of antibodies in blood and organ donors with risk factors.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The transmission of HTLV after transplantation of solid organs from infected donors has been documented extensively.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> Back in 2003, the first 3 cases of HTLV-I transmission after transplantation of 1 liver and 2 kidneys from the same infected donor<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–11</span></a> were reported. All organ receivers presented with tropical spastic paraparesis that lead to paralysis or very high disability.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Taking into consideration the importance of the transmission of this infection through solid organ transplantation, we studied the prevalence of antibodies against HTLV I/II lymphotropic viruses in potential organ donors of Asturias, Spain. Then we analyzed all brain deaths that occurred in the intensive care units from 2014 through 2018, both years included. We collected epidemiological data and serological test results for the HTLV I/II viruses in potential organ donors after excluding negative and medical contraindications for donation. The risk factors for HTLV I/II infection analyzed were the geographical region of birth/habitual residence, drug addiction through parenteral route, and high-risk sexual activity. The screening for antibiotics was conducted using the chemiluminescent assay (CLIA) with the Liaison XL automated system (Liaison® XL murex recHTLV-I/II, DiaSorin). This system detects anti-HTLV-I and anti-HTLV-II antibodies simultaneously without discriminating HTLV-I from HTLV-II antibodies. The CLIA-positive specimens were confirmed in a second ELISA test and then sent to <span class="elsevierStyleItalic">Instituto de Salud Carlos III</span> for Western Blot confirmation test. The CLIA technique was conducted for 1<span class="elsevierStyleHsp" style=""></span>h and the cost of the chemically reactive agent were €3. Conducting this test meant no delay in the logistics of the donation process. A total of 297 brain deaths were analyzed. Of these, 11 were discarded due to medical contraindication and 23 due to refusal to donate (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Of the 263 brain deaths that were organ donors, 139 (52.9%) were males and 124 (47.1%) were women with a mean age of 62.4 years and an average hospital stay from admission until organ extraction of 4.73 days. Eight hundred and forty-one organs were extracted from these donors, out of which 610 were transplanted. Regarding nationality, only 9 donors (3.4%) were foreigners out of which 4 (1.5%) came from countries at risk (Colombia, Cuba, Dominican Republic, and Peru). Regarding other risk factors, only 1 donor (0.4%) was involved in high-risk sexual activity. Two potential donors (0.76%) tested HTLV I/II-positive in the CLIA, one of them with a threshold value of 1.3 arbitrary units (upper limit of normal: 1.0) that was considered a false positive. In the other one, the CLIA showed 4.0 arbitrary units and was discarded as a donor. The Western Blot tested negative in both cases confirming the false positive results, representative of 0.76% of all determinations. These results conditioned the loss of 1 donor. In light of our study, we concluded that the seroprevalence for HTLV I/II in potential organ donors in Asturias is low. However, the progressive increase of migration flows, the difficulty obtaining risk factors in the clinical history, and the rate of asymptomatic unaware HTLV I carriers may increase the risk of HTLV transmission through organ transplants. On the other hand, transplanted patients on immunosuppressant therapy have more chances of developing HTLV-I-related conditions that are associated with a higher mortality rate and significant disability. Therefore, to improve the quality and safety of transplanted organs, the next review of the Study Group on Infection in Compromised Hosts Consensus Document from the Transplant Infection and National Transplant Organization of the MSC on selection criteria of donors regarding the transmission of infections<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> will be recommending the universal screening for HTLV-I with serological tests of all organ donors.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0020" class="elsevierStylePara elsevierViewall">None reported.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Leizaola Irigoyen O, Leoz Gordillo B, Balboa Palomino S, Rodríguez Perez M, Mahillo Durán B, Escudero Augusto D. Seroprevalencia de anticuerpos frente a virus linfotrópicos humanos (HTLV I y II) en donantes de órganos. Med Intensiva. 2020;44:451–453.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1080 "Ancho" => 1386 "Tamanyo" => 55046 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Brain deaths, donors, and seroprevalence of HTLV (2014–2018).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibodies to human T-lymphotropic virustype-i in patients with tropical spastic paraparesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gessain" 1 => "F. Barin" 2 => "J.C. Vernant" 3 => "O. Gout" 4 => "L. Maurs" 5 => "A. Calen-der" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S2468-1253(17)30072-9" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1985" "volumen" => "2" "paginaInicial" => "407" "paginaFinal" => "410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28497756" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic neurodegenerative disease associatedwith HTLV-II infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Hjelle" 1 => "O. Appenzeller" 2 => "R. Mills" 3 => "S. Alexander" 4 => "N. Torrezmartinez" 5 => "R. Jahnke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0140-6736(92)90797-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1992" "volumen" => "339" "paginaInicial" => "645" "paginaFinal" => "646" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1347339" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Globalepidemiology of HTLV-1 infection and associated diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Proietti" 1 => "A. Carneiro-Proietti" 2 => "B. Catalan" 3 => "E. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Onco-gene" "fecha" => "2005" "volumen" => "24" "paginaInicial" => "6058" "paginaFinal" => "6068" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human T-cell lymphotropicvirus tipe i and ii in transfusion medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.G. Sandler" 1 => "C.T. Fang" 2 => "A.E. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0887-7963(91)70197-1" "Revista" => array:7 [ "tituloSerie" => "Transfus Med Rev" "fecha" => "1991" "volumen" => "5" "paginaInicial" => "93" "paginaFinal" => "107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1687974" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1878875015012103" "estado" => "S300" "issn" => "18788750" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HumanT-cell lymphotrophic virus in solid-organ transplant reci-pients: Guidelines from the American society of transplantationinfectious diseases community of practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.R. Kaul" 1 => "T.S. Sharma" 2 => "AST ID Community of Practice" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ctr.13575" "Revista" => array:2 [ "tituloSerie" => "Clin Transplant" "fecha" => "2019" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human T-lymphotropic virus type 1 infection andsolid organ transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.P. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/rmv.1970" "Revista" => array:4 [ "tituloSerie" => "Rev Med Virol" "fecha" => "2018" "volumen" => "28" "paginaInicial" => "e1970" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HTLV-1 myelopathy after renal transplant and antiviralprophylaxis: the need for screening" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Moreno-Ajona" 1 => "J.R. Yuste" 2 => "P. Martín" 3 => "J. Gállego Pérez-Larraya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s13365-018-0627-3" "Revista" => array:7 [ "tituloSerie" => "J Neurovirol" "fecha" => "2018" "volumen" => "24" "paginaInicial" => "523" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29532443" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1878875014005397" "estado" => "S300" "issn" => "18788750" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human T-cellleukemia virus type i infection in various recipients of trans-plants from the same donor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.P. González-Pérez" 1 => "L. Mu˜noz-Juárez" 2 => "F. Cárdenas" 3 => "J. Zarranz Imi-rizaldu" 4 => "J. Corral Carranceja" 5 => "A. García-Saiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.TP.0000058470.15921.CA" "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2003" "volumen" => "75" "paginaInicial" => "1006" "paginaFinal" => "1011" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12698089" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infección por HTLV post-trasplante renal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Villafruela" 1 => "A. Arruza" 2 => "J. Martín" 3 => "I. Azurmendi" 4 => "J.A. Zabala" 5 => "C. Per-tusa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4321/s0004-06142005001000011" "Revista" => array:6 [ "tituloSerie" => "Arch Esp Urol" "fecha" => "2005" "volumen" => "58" "paginaInicial" => "1064" "paginaFinal" => "1068" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16482858" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid development ofsubacute myelopathy in three organ transplant recipients altertransmision of human T-cell lymphotropic virus type i from asingle donor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Toro" 1 => "B. Rodés" 2 => "E. Poveda" 3 => "V. Soriano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00007890-200301150-00019" "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2003" "volumen" => "75" "paginaInicial" => "102" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12544880" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HumanT-lymphotropic virus type I (HTLV-I) associated myelopathyacquired through a liver transplant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.J. Zarranz" 1 => "I. Rouco" 2 => "J.C. Gómez-Esteban" 3 => "J. Corral" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp.71.6.818a" "Revista" => array:5 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2001" "volumen" => "71" "paginaInicial" => "818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11762320" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Documento de Consenso sobre Criterios de selección deldonante de órganos respecto a la transmisión de infeccio-nes. 2.a edición. 2004. Available from: <a target="_blank" href="http://www.ont.es/infesp/DocumentosDeConsenso/infecciondonante.pdf">http://www.ont.es/infesp/DocumentosDeConsenso/infecciondonante.pdf</a>. (accessed 10 Apr 2019)." ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human T-lymphotropic virus type 1 infectionand disease in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. De Mendoza" 1 => "E. Caballero" 2 => "A. Aguilera" 3 => "S. Requena" 4 => "R.O. de Leiarazu" 5 => "M. Pirón" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/QAD.0000000000001527" "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "2017" "volumen" => "31" "paginaInicial" => "1653" "paginaFinal" => "1663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28700391" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735727/0000004400000007/v1_202010040640/S2173572719301729/v1_202010040640/en/main.assets" "Apartado" => array:4 [ "identificador" => "15647" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735727/0000004400000007/v1_202010040640/S2173572719301729/v1_202010040640/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572719301729?idApp=WMIE" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 55 | 32 | 87 |
| 2024 September | 63 | 39 | 102 |
| 2024 August | 76 | 38 | 114 |
| 2024 July | 77 | 34 | 111 |
| 2024 June | 58 | 38 | 96 |
| 2024 May | 57 | 39 | 96 |
| 2024 April | 63 | 36 | 99 |
| 2024 March | 64 | 33 | 97 |
| 2024 February | 94 | 46 | 140 |
| 2024 January | 70 | 36 | 106 |
| 2023 December | 94 | 48 | 142 |
| 2023 November | 72 | 45 | 117 |
| 2023 October | 77 | 35 | 112 |
| 2023 September | 78 | 38 | 116 |
| 2023 August | 54 | 23 | 77 |
| 2023 July | 76 | 24 | 100 |
| 2023 June | 72 | 16 | 88 |
| 2023 May | 77 | 39 | 116 |
| 2023 April | 63 | 24 | 87 |
| 2023 March | 84 | 27 | 111 |
| 2023 February | 89 | 30 | 119 |
| 2023 January | 59 | 24 | 83 |
| 2022 December | 85 | 38 | 123 |
| 2022 November | 78 | 46 | 124 |
| 2022 October | 93 | 40 | 133 |
| 2022 September | 69 | 38 | 107 |
| 2022 August | 69 | 45 | 114 |
| 2022 July | 62 | 41 | 103 |
| 2022 June | 46 | 27 | 73 |
| 2022 May | 68 | 34 | 102 |
| 2022 April | 81 | 47 | 128 |
| 2022 March | 94 | 47 | 141 |
| 2022 February | 66 | 51 | 117 |
| 2022 January | 99 | 42 | 141 |
| 2021 December | 89 | 54 | 143 |
| 2021 November | 116 | 45 | 161 |
| 2021 October | 93 | 92 | 185 |
| 2021 September | 70 | 40 | 110 |
| 2021 August | 95 | 51 | 146 |
| 2021 July | 57 | 40 | 97 |
| 2021 June | 55 | 36 | 91 |
| 2021 May | 103 | 51 | 154 |
| 2021 April | 281 | 74 | 355 |
| 2021 March | 182 | 41 | 223 |
| 2021 February | 147 | 35 | 182 |
| 2021 January | 189 | 32 | 221 |
| 2020 December | 2 | 0 | 2 |
| 2020 July | 22 | 13 | 35 |
| 2020 June | 37 | 21 | 58 |
| 2020 May | 19 | 10 | 29 |
| 2020 April | 27 | 11 | 38 |
| 2020 March | 1 | 0 | 1 |
Show all
