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which peaked on April 3<span class="elsevierStyleSup">rd</span>&#44; whether now we included two weeks of decreasing pressure on ICU&#58; the association between CFR and ICAR is still present&#44; but in the multivariate regression model only the incidence had a significant effect&#46; Lombardy was the epicenter of the out-break and the region with higher CFR&#58; it was an outlier&#44; probably contributing to reduce the coefficient of determination &#40;<span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span>&#41; in the correlation between CFR and ICUAR&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">During different time-frame of such a huge outbreak the key factors associated with CFR may play different roles&#58; the incidence seems to be strongly associated with CFR&#44; but the ICUAR could be associated especially during the increasing of out-break when the ICU capability could be overwhelmed&#46; According to this hypothesis different health-care resources should be implemented in different out-break time-frame&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">On behalf of all authors&#44; 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Letter to the Editor
COVID-19 mortality and health-care resources: Organization
Mortalidad de COVID-19 y recursos sanitarios: organización
P. Immovillia,
Corresponding author
paolo.immovilli.md@gmail.com

Corresponding author.
, N. Morellia, E. Rotab, D. Guidettia
a Neurology Unit, Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy
b Neurology Unit, ASL Alessandria, Italy
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the high average age of the Italian population&#44; the definition of COVID-19-related deaths&#44; the pharyngeal swab testing strategy employed and the CFR variation in different epidemic time-frame&#46; It has been postulated that the confirmed diagnosis of milder cases could increase with the number of swabs taken&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">A univariate analysis of Italian regional data showed a strong correlation between CFR and COVID-19 incidence &#40;<span class="elsevierStyleItalic">R</span> 0&#46;715&#44; <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> 0&#46;511&#44; <span class="elsevierStyleItalic">p</span>-value 0&#46;000&#41;&#44; an inverse correlation between CFR and ICUAR &#40;<span class="elsevierStyleItalic">R</span> &#8722;0&#46;466&#44; <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> 0&#46;217&#44; <span class="elsevierStyleItalic">p</span>-value 0&#46;033&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The pharyngeal swab per 10&#44;000 people did not correlate with the CFR &#40;<span class="elsevierStyleItalic">p</span>-value 0&#46;368&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The multivariate analysis showed that CFR was only associated with COVID-19 incidence &#40;<span class="elsevierStyleItalic">p</span>-value 0&#46;001&#41;&#44; but neither with ICUAR &#40;<span class="elsevierStyleItalic">p</span>-value 0&#46;172&#41;&#44; nor with pharyngeal swab per 10&#44;000 people &#40;<span class="elsevierStyleItalic">p</span>-value 0&#46;221&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The different COVID-19 incidence and ICU capability in the Italian Regions showed that mortality was linked to high incidence and ICU capability&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Our previous analysis was done during the continuous everyday increasing of ICU patients&#44; which peaked on April 3<span class="elsevierStyleSup">rd</span>&#44; whether now we included two weeks of decreasing pressure on ICU&#58; the association between CFR and ICAR is still present&#44; but in the multivariate regression model only the incidence had a significant effect&#46; Lombardy was the epicenter of the out-break and the region with higher CFR&#58; it was an outlier&#44; probably contributing to reduce the coefficient of determination &#40;<span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span>&#41; in the correlation between CFR and ICUAR&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">During different time-frame of such a huge outbreak the key factors associated with CFR may play different roles&#58; the incidence seems to be strongly associated with CFR&#44; but the ICUAR could be associated especially during the increasing of out-break when the ICU capability could be overwhelmed&#46; According to this hypothesis different health-care resources should be implemented in different out-break time-frame&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">On behalf of all authors&#44; 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ISSN: 21735727
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Idiomas
Medicina Intensiva (English Edition)
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