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One year later&#44; several agencies were recommending PCP as one of the potential therapies to treat severe cases of MERS-CoV<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The SARS-CoV-2 pandemic caused a health crisis worldwide collapsing intensive care units &#40;ICU&#41; with patients with pneumonia and acute respiratory distress syndrome &#40;ARDS&#41;&#46; Because of the lack of effective treatments&#44; the use of plasma from convalescent patients was initially suggested as a source of antibodies with the idea that it could improve the course of the disease if used early by reducing early viremia for the lack of antibodies or when the total count of antibody titers &#40;IgM and IgG&#41; is low<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">6&#44;7</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A study was conducted with patients admitted to a polyvalent ICU at a tertiary care hospital with 44 beds prior to the pandemic &#40;from September 2020 through December 2020&#41; to assess the efficacy and safety profile of PCP in severe patients with COVID-19 who had not developed antibodies&#46; To assess efficacy the days patients had been on mechanical ventilation&#44; as well as mortality were taken into consideration&#46; To assess safety the absence of clinical complications potentially attributed to the administration of plasma was considered as well&#46; Inclusion criteria were patients over 18 years-old admitted with mild&#44; moderate&#44; or severe ARDS or according to Berlin Definition and who required mechanical ventilation&#46; The presence of SARS-CoV-2 for the diagnosis of COVID-19 was confirmed after the detection of viral genome using multiple quantitative RT-PCR testing&#46; Nucleic acids were purified using the MagNa Pure 96 System &#40;Roche&#44; Geneva&#44; Switzerland&#41;&#46; Extractions underwent an amplification reaction using the TaqMan Fast 1-Step Master Mix &#40;Life technologies&#44; Carlsbad&#44; CA&#44; United States&#41; plus a mix of primers &#40;Thermo Fisher Scientific&#44; Walthman&#44; MA&#44; United States&#41; and taqman MGB probes &#40;Applied Biosystems&#44; Foster City&#44; CA&#44; United States&#41; directed against 2 different targets&#58; ORF1ab and N&#46; Amplifications and further analyses were conducted using the Applied Biosystems 7500 Real-time PCR System&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Individuals from the control group were patients matched by age&#44; sex&#44; and severity admitted to the ICU during the same study period who met some exclusion criterion &#40;presence of antibodies in plasma and date of ICU admission after the first 10 days since symptom onset&#41;&#46; Statistical analysis&#58; qualitative variables were expressed as absolute frequencies and percentages&#46; Quantitative variables were expressed as mean&#44; median&#44; and standard deviation Comparative analysis was conducted using the Student-Welch&#44; the chi-square tests&#44; and the Kaplan-Meier survival analysis calculator&#46; All <span class="elsevierStyleItalic">P</span> values and confidence intervals were estimated and assessed using a bilateral 95&#37; confidence level&#46; The study was approved by the research ethics committee of Principality of Asturias&#44; Spain &#40;code &#35;2020&#46;196&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Plasma from convalescent patients was obtained through altruistic donation from patients who had recovered from COVID-19&#46; Only convalescent patients with anti-SARS-CoV-2 antibody values 5 times higher than the cut-off value considered positive were considered eligible for donation&#46; Antibody count was conducted using the fully automated chemiluminescence analyzer LIAISONXL&#174; &#40;LIAISON&#174; SARS-CoV-2 TrimericS IgG&#44; DiaSorin&#44; VC&#44; Italy&#41;&#46; Results are presented in arbitrary units per mL &#40;AU&#47;mL&#41; with a lower limit of 13&#160;AU&#47;mL&#44; and a maximum response of 800&#160;AU&#47;mL&#46; Plasma was obtained through plasmapheresis at the Community Blood Center Regional Tissue Bank&#46; A total of 500&#8211;600&#160;mL of plasma were drawn in each donation&#46; Afterwards&#44; a process of viral inactivation with methylene blue dye followed that was frozen until used according to standard procedures in place at the blood bank&#46; Patients were infused with 2 bags of PCP for a total of 500&#160;mL&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study was conducted on a total of 81 patients&#44; 28 of whom were treated with PCP and 53 were considered controls&#46; Patients were matched according to age&#44; sex&#44; and APACHE II score at admission&#46; No significant differences were reported between both groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; A total of 35&#37; of the patients were women&#44; and the mean age was 67&#46;6 years&#46; The overall mortality rate was 38&#46;2&#37;&#46; Patients were treated with PCP for a median of 9 days since symptom onset and 2 days since ICU admission&#46; From symptom onset until intubation&#44; the mean of patients who received convalescent plasma was 8&#46;3 days &#40;3&#8211;17&#41; compared to 9&#46;1 days &#40;1&#8211;16&#41; from the control group&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Days at the ICU or at the hospital&#44; and days on mechanical ventilation were fewer in the group of patients treated with PCP although a statistically significant difference could not be seen &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Comparing these same variables among survivors from each group&#44; patients treated with PCP had been a median of 8 days on mechanical ventilation compared to the 14 days of patients na&#239;ve to treatment &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;19&#41;&#44; ICU stays of 10 days compared to 16 days in patients na&#239;ve to treatment &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;66&#41;&#44; and hospital stays of 26 days compared to 32 days &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;50&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The mortality rate of patients treated with PCP was 46&#46;4&#37; compared to 33&#46;9&#37; of patients from the control group &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;27&#41;&#46; Analyzing the Kaplan-Meier survival chart&#44; <span class="elsevierStyleItalic">P</span> values&#160;&#61;&#160;&#46;14 were obtained &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No adverse events associated with the use of PCP were reported&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Therefore&#44; in our own experience&#44; the transfusion of plasma from convalescent patients to critically ill patients with SARS-CoV-2 induced pneumonia does not reduce mortality&#44; the days on mechanical ventilation or the ICU stay&#46; Some study limitations are its small sample size that lacks the necessary statistical power to be able to draw definitive conclusions&#44; and the method used to select both cases and control patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Despite the fact that other infectious diseases have had good results with the use of PCP our findings are consistent with those obtained from different studies conducted during the past 2 pandemic years&#46; These findings tell us that no clinical benefits have been reported in severe patients<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">8</span></a>&#44; or in patients with mild symptoms as possible inhibitor of disease progression into severe stages of the disease<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">9</span></a>&#46; However&#44; a study recently published found a lower risk of disease progression into severe forms of the disease in patients treated with PCP within the first 9 days since symptom onset<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">10</span></a>&#46; Currently&#44; although it is not recommended to administer PCP systematically in severe cases of COVID-19&#44; its efficacy in mild patients or other subgroup of immunosuppressed patients remains uncertain&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Iv&#225;n Astola and Dolores Escudero drafted the manuscript&#46; Iv&#225;n Astola&#44; Mar&#237;a Mart&#237;nez&#44; &#193;ngeles Fern&#225;ndez&#44; and Eva Mart&#237;nez were involved in data curation&#46; Ana Mar&#237;a Ojea&#44; and Pablo Herrero selected the donors&#46; All the authors reviewed the manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">This research study was funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Fundaci&#243;n para la Investigaci&#243;n Biosanitaria de Asturias</span>&#40;FIMBA&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Research Ethics Committee Approval with code &#35;2020&#46;196&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None whatsoever&#46;</p></span></span>"
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    "fechaRecibido" => "2022-04-19"
    "fechaAceptado" => "2022-06-21"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a&#8211;c&#41; Graphic representation of the comparative analysis between cases and controls&#46; DMV&#44; days on mechanical ventilation&#46; d&#41; Survival chart&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">MV&#44; mechanical ventilation&#59; PCP&#44; plasma from convalescent patients&#59; SD&#44; standard deviation&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients on PCP<span class="elsevierStyleItalic">N</span>&#160;&#61;&#160;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Women &#91;n &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;35&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Age &#91;mean &#40;SD&#41;&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;87&nbsp;\t\t\t\t\t\t\n
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Cheng"
                            1 => "R&#46; Wong"
                            2 => "Y&#46;O&#46;Y&#46; Soo"
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Scientific Letter
Clinical outcomes of using plasma in COVID-19 convalescent critically ill patients
Resultados del uso de plasma de pacientes convalecientes de COVID-19 en pacientes críticos
I. Astola Hidalgoa,
Corresponding author
iastolahidalgo@gmail.com

Corresponding author.
, A. Fernández Rodríguezc, E. Martínez Revueltac, M. Martínez Revueltaa, A.M. Ojeae, P. Herrero Puented, D. Escudero Augustoa,b
a Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Spain
b Grupo de Investigación Microbiología Traslacional del Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain
c Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
d Servicio de Urgencias, Hospital Universitario Central de Asturias, Oviedo, Spain
e Centro Comunitario regional de Sangre y Tejidos, Oviedo, Asturias, Spain
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        "titulo" => "Resultados del uso de plasma de pacientes convalecientes de COVID-19 en pacientes cr&#237;ticos"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a&#8211;c&#41; Graphic representation of the comparative analysis between cases and controls&#46; DMV&#44; days on mechanical ventilation&#46; d&#41; Survival chart&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The use of plasma from patients who have recovered from viral infections was used for the first time back in the 20<span class="elsevierStyleSup">th</span> century to treat cases of the so-called Spanish flu<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; More recently&#44; plasma from convalescent patients &#40;PCP&#41; has been effective and safely used to treat respiratory infections due to SARS-CoV and the Middle East respiratory syndrome &#40;MERS-CoV&#41;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Some studies have demonstrated a better clinical evolution when used within the first 14 days<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Back in 2014&#44; the World Health Organization &#40;WHO&#41; recommended its use to treat Ebola virus disease categorizing it as empirical treatment<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a>&#46; One year later&#44; several agencies were recommending PCP as one of the potential therapies to treat severe cases of MERS-CoV<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The SARS-CoV-2 pandemic caused a health crisis worldwide collapsing intensive care units &#40;ICU&#41; with patients with pneumonia and acute respiratory distress syndrome &#40;ARDS&#41;&#46; Because of the lack of effective treatments&#44; the use of plasma from convalescent patients was initially suggested as a source of antibodies with the idea that it could improve the course of the disease if used early by reducing early viremia for the lack of antibodies or when the total count of antibody titers &#40;IgM and IgG&#41; is low<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">6&#44;7</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A study was conducted with patients admitted to a polyvalent ICU at a tertiary care hospital with 44 beds prior to the pandemic &#40;from September 2020 through December 2020&#41; to assess the efficacy and safety profile of PCP in severe patients with COVID-19 who had not developed antibodies&#46; To assess efficacy the days patients had been on mechanical ventilation&#44; as well as mortality were taken into consideration&#46; To assess safety the absence of clinical complications potentially attributed to the administration of plasma was considered as well&#46; Inclusion criteria were patients over 18 years-old admitted with mild&#44; moderate&#44; or severe ARDS or according to Berlin Definition and who required mechanical ventilation&#46; The presence of SARS-CoV-2 for the diagnosis of COVID-19 was confirmed after the detection of viral genome using multiple quantitative RT-PCR testing&#46; Nucleic acids were purified using the MagNa Pure 96 System &#40;Roche&#44; Geneva&#44; Switzerland&#41;&#46; Extractions underwent an amplification reaction using the TaqMan Fast 1-Step Master Mix &#40;Life technologies&#44; Carlsbad&#44; CA&#44; United States&#41; plus a mix of primers &#40;Thermo Fisher Scientific&#44; Walthman&#44; MA&#44; United States&#41; and taqman MGB probes &#40;Applied Biosystems&#44; Foster City&#44; CA&#44; United States&#41; directed against 2 different targets&#58; ORF1ab and N&#46; Amplifications and further analyses were conducted using the Applied Biosystems 7500 Real-time PCR System&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Individuals from the control group were patients matched by age&#44; sex&#44; and severity admitted to the ICU during the same study period who met some exclusion criterion &#40;presence of antibodies in plasma and date of ICU admission after the first 10 days since symptom onset&#41;&#46; Statistical analysis&#58; qualitative variables were expressed as absolute frequencies and percentages&#46; Quantitative variables were expressed as mean&#44; median&#44; and standard deviation Comparative analysis was conducted using the Student-Welch&#44; the chi-square tests&#44; and the Kaplan-Meier survival analysis calculator&#46; All <span class="elsevierStyleItalic">P</span> values and confidence intervals were estimated and assessed using a bilateral 95&#37; confidence level&#46; The study was approved by the research ethics committee of Principality of Asturias&#44; Spain &#40;code &#35;2020&#46;196&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Plasma from convalescent patients was obtained through altruistic donation from patients who had recovered from COVID-19&#46; Only convalescent patients with anti-SARS-CoV-2 antibody values 5 times higher than the cut-off value considered positive were considered eligible for donation&#46; Antibody count was conducted using the fully automated chemiluminescence analyzer LIAISONXL&#174; &#40;LIAISON&#174; SARS-CoV-2 TrimericS IgG&#44; DiaSorin&#44; VC&#44; Italy&#41;&#46; Results are presented in arbitrary units per mL &#40;AU&#47;mL&#41; with a lower limit of 13&#160;AU&#47;mL&#44; and a maximum response of 800&#160;AU&#47;mL&#46; Plasma was obtained through plasmapheresis at the Community Blood Center Regional Tissue Bank&#46; A total of 500&#8211;600&#160;mL of plasma were drawn in each donation&#46; Afterwards&#44; a process of viral inactivation with methylene blue dye followed that was frozen until used according to standard procedures in place at the blood bank&#46; Patients were infused with 2 bags of PCP for a total of 500&#160;mL&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study was conducted on a total of 81 patients&#44; 28 of whom were treated with PCP and 53 were considered controls&#46; Patients were matched according to age&#44; sex&#44; and APACHE II score at admission&#46; No significant differences were reported between both groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; A total of 35&#37; of the patients were women&#44; and the mean age was 67&#46;6 years&#46; The overall mortality rate was 38&#46;2&#37;&#46; Patients were treated with PCP for a median of 9 days since symptom onset and 2 days since ICU admission&#46; From symptom onset until intubation&#44; the mean of patients who received convalescent plasma was 8&#46;3 days &#40;3&#8211;17&#41; compared to 9&#46;1 days &#40;1&#8211;16&#41; from the control group&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Days at the ICU or at the hospital&#44; and days on mechanical ventilation were fewer in the group of patients treated with PCP although a statistically significant difference could not be seen &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Comparing these same variables among survivors from each group&#44; patients treated with PCP had been a median of 8 days on mechanical ventilation compared to the 14 days of patients na&#239;ve to treatment &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;19&#41;&#44; ICU stays of 10 days compared to 16 days in patients na&#239;ve to treatment &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;66&#41;&#44; and hospital stays of 26 days compared to 32 days &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;50&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The mortality rate of patients treated with PCP was 46&#46;4&#37; compared to 33&#46;9&#37; of patients from the control group &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;27&#41;&#46; Analyzing the Kaplan-Meier survival chart&#44; <span class="elsevierStyleItalic">P</span> values&#160;&#61;&#160;&#46;14 were obtained &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No adverse events associated with the use of PCP were reported&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Therefore&#44; in our own experience&#44; the transfusion of plasma from convalescent patients to critically ill patients with SARS-CoV-2 induced pneumonia does not reduce mortality&#44; the days on mechanical ventilation or the ICU stay&#46; Some study limitations are its small sample size that lacks the necessary statistical power to be able to draw definitive conclusions&#44; and the method used to select both cases and control patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Despite the fact that other infectious diseases have had good results with the use of PCP our findings are consistent with those obtained from different studies conducted during the past 2 pandemic years&#46; These findings tell us that no clinical benefits have been reported in severe patients<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">8</span></a>&#44; or in patients with mild symptoms as possible inhibitor of disease progression into severe stages of the disease<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">9</span></a>&#46; However&#44; a study recently published found a lower risk of disease progression into severe forms of the disease in patients treated with PCP within the first 9 days since symptom onset<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">10</span></a>&#46; Currently&#44; although it is not recommended to administer PCP systematically in severe cases of COVID-19&#44; its efficacy in mild patients or other subgroup of immunosuppressed patients remains uncertain&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Iv&#225;n Astola and Dolores Escudero drafted the manuscript&#46; Iv&#225;n Astola&#44; Mar&#237;a Mart&#237;nez&#44; &#193;ngeles Fern&#225;ndez&#44; and Eva Mart&#237;nez were involved in data curation&#46; Ana Mar&#237;a Ojea&#44; and Pablo Herrero selected the donors&#46; All the authors reviewed the manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">This research study was funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Fundaci&#243;n para la Investigaci&#243;n Biosanitaria de Asturias</span>&#40;FIMBA&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Research Ethics Committee Approval with code &#35;2020&#46;196&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None whatsoever&#46;</p></span></span>"
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          "titulo" => "References"
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    "fechaRecibido" => "2022-04-19"
    "fechaAceptado" => "2022-06-21"
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        "texto" => "<p id="par0080" class="elsevierStylePara elsevierViewall">We wish to thank all COVID-19 convalescent patients who donated their plasma for their generosity that made this study possible&#46; Our gratitude also goes to the Spanish Society of Medicine and Plastic Surgery for the donation made on behalf of Fundaci&#243;n para la Investigaci&#243;n Biosanitaria de Asturias &#40;FIMBA&#41; to be able to conduct this study&#46;</p>"
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ISSN: 21735727
Original language: English
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