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Available online 3 February 2025
Analgosedation and delirium practices in critically ill patients in the Pan-American and Iberian setting, and factors associated with oversedation after the COVID-19 pandemic: Results from the PANDEMIC study
Prácticas de analgosedación y delirium en pacientes críticos de la región Panamericana e Ibérica y factores asociados a la sobresedación tras la pandemia COVID-19: resultados del estudio PANDEMIC
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Carola Giménez-Esparza Vicha,&#¿;
Corresponding author
, Felipe Martínezb, Daniela Olmos Kutscherauerc, Daniel Molanod, Maria del Carmen Gallardoe, Enrique Mario Olivares-Duránf,g, Jesús Caballeroh, Rosa Reinai, Manuela García Sánchezj, Federico C. Carinik,l, Comité de Analgesia, Sedación y Delirium de la Federación Panamericana e Ibérica de Cuidados Críticos y Terapia Intensiva (FEPIMCTI)
a Servicio de Medicina Intensiva, Hospital Vega Baja, Orihuela, Alicante, Spain
b Facultad de Medicina, Escuela de Medicina, Universidad Andrés Bello, Viña del Mar, Chile
c Terapia Intensiva, Hospital Municipal Príncipe de Asturias; Profesora Asistente por Concurso de la Cátedra de Semiología UNC, Córdoba, Argentina
d Unidad de Cuidado Intensivo, Hospital de San José; Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia
e Unidad de Terapia Intensiva, Hospital Municipal La Merced, La Paz, Bolivia
f Unidad Médica de Alta Especialidad No. 1, Centro Médico Nacional del Bajío, Instituto Mexicano del Seguro Social, León, Mexico
g Departamento de Enfermería y Obstetricia Sede León; División de Ciencias de la Salud, Universidad de Guanajuato, Campus León, León, Mexico
h Servei de Medicina Intensiva, Hospital Universitari Arnau de Vilanova de Lleida, IRBLleida, Lleida, Spain
i Servicio de Terapia Intensiva, Hospital San Martín, La Plata; Docente Cátedra Terapia Intensiva, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Buenos Aires, Argentina
j Unidad de Cuidados Intensivos, Hospital Universitario Virgen Macarena, Sevilla, Spain
k Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
l Unidad de Terapia Intensiva de Adultos, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
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Tables (4)
Table 1. Sociodemographic characteristics of the study participants and centers.
Table 2. Changes in analgosedation practices during and after the COVID-19 pandemic.
Table 3. Changes in the management of delirium during the pandemic.
Table 4. Multiple logistic regression analysis: factors associated with the persistence of oversedation after the COVID-19 pandemic (pseudo R2&#¿;=&#¿;8.3%).
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Abstract

Oversedation has adverse effects on critically ill patients. The Analgosedation and Delirium Committee of the FEPIMCTI (Pan-American and Iberian Federation of Critical Care Medicine and Intensive Care) conducted a cross-sectional study through a survey addressed to ICU physicians: PANDEMIC (Pan-American and Iberian Study on the Management of Analgosedation and Delirium in Critical Care [fepImCti]).

Hypothesis

Worsening of these practices in the course of the pandemic and that continued afterwards, with further oversedation.

Objectives

Perception of analgosedation and delirium practices in Pan-American and Iberian ICUs before, during and after the COVID-19 pandemic, and factors associated with persistent oversedation after the pandemic.

Of the 1008 respondents, 25% perceived oversedation after the pandemic (95%CI 22.4–27.8). This perception was higher in South America (35.8%, P&#¿;<&#¿;.001). Main risk factor: habit acquired during the pandemic (adjusted OR [aOR] 3.16, 95%CI 2.24–4.45, P&#¿;<&#¿;.001). Main protective factor: delirium monitoring before the pandemic (aOR 0.70, 95%CI 0.50−0.98, P&#¿;=&#¿;.038).

The factors identified in this study provide a basis for targeting future interventions.

Keywords:
Analgosedation
Delirium
Critically ill patient
Oversedation
Deep sedation
COVID-19 pandemic
ABCDEF bundle
Resumen

La sobresedación tiene consecuencias negativas en pacientes críticos. Desde el Comité de Analgosedación y Delirium de la FEPIMCTI (Federación Panamericana e Ibérica de Medicina Crítica y Terapia Intensiva) diseñamos estudio transversal mediante encuesta dirigida a médicos/as de UCI: PANDEMIC [estudio Panamericano e Ibérico sobre manejo de ANalgosedación y DEliriuM en Cuidados Críticos (fepImCti)].

Hipótesis

Empeoramiento de dichas prácticas durante la pandemia que persistieron tras ella, con mayor sobresedación.

Objetivos

Percepción de prácticas de analgosedación y delirium en las UCI de la región Panamericana e Ibérica, antes, durante y después de la pandemia COVID-19 y factores asociados a persistencia sobresedación post-pandemia.

De los 1008 encuestados, 25% informó percepción de sobresedación tras la pandemia (IC95% 22.4%–27.8%), mayor en Sudamérica (35.8%, P&#¿;<&#¿;.001). Principal factor riesgo: hábito adquirido durante la pandemia (OR ajustado [aOR] 3.16, IC95% 2.24–4.45, P&#¿;<&#¿;.001). Principal factor protector: monitorización delirium (aOR 0.70, IC95% 0.50−0.98, P&#¿;=&#¿;.038) previo a la pandemia.

Estos factores identificados en el estudio ofrecen una base para dirigir intervenciones futuras.

Palabras clave:
Analgosedación
Delirium
Paciente crítico
Sobresedación
Sedación profunda
Pandemia COVID-19
Paquete medidas ABCDEF

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