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few studies have explored its measurement in patients diagnosed with sepsis or septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A previous systematic review identified only five publications that evaluated SI in patients with septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; in recent years&#44; new studies have been published that continue to highlight the importance of this index in prognosis&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and recently other forms of evaluating SI have been described&#44; such as the Modified Shock Index &#40;MSI&#41; and the Diastolic Shock Index &#40;DSI&#41;&#44; considering the pathophysiological basis of sepsis&#44; with results suggesting a benefit in using it as a prognostic tool and potentially for the management of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The latest version of the Surviving Sepsis Campaign &#40;SSC&#41; recommends measuring mean arterial pressure and establishes a therapeutic target for this measure during the initial management of patients with septic shock&#46; Additionally&#44; they suggest measuring blood lactate and capillary refill time as a way to evaluate tissue perfusion status&#44; recommending their normalization when altered&#46; Although other hemodynamic and tissue perfusion variables have been investigated&#44; the SSC does not offer recommendations on evaluating other types of physiological variables&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> SI may be a useful measure to complement patient care&#44; particularly due to its ease of measurement in any medical care setting&#46; The objective of this review is to determine the association of SI and its various derivatives with clinical outcomes and mortality in patients with septic shock&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patients and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We conducted a systematic literature review&#44; including observational studies &#40;cohorts&#44; case-controls&#44; cross-sectional&#41; and experimental studies in humans&#44; published in any language from 1969 through September 2023&#44; which included adult patients diagnosed with severe sepsis or septic shock &#40;using a standardized definition&#41;&#44; and evaluated SI &#40;heart rate&#47;systolic blood pressure&#41; or some modified version including the MSI &#40;HR&#47;MAP&#41; &#40;MAP&#44; mean arterial pressure&#41; and the DSI &#40;HR&#47;DBP&#41; &#40;DBP&#44; diastolic blood pressure&#41;&#46; Studies published in abstract format or that could not be obtained in full text&#44; studies in COVID-19 patients&#44; and obstetric populations were excluded&#46; The protocol for this systematic review was registered in PROSPERO with No&#46; CRD42023473588&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Search structure</span><p id="par0025" class="elsevierStylePara elsevierViewall">A systematic literature search was conducted across various databases including PubMed&#44; Embase&#44; Cochrane Library&#44; and Lilacs&#46; In PubMed&#44; the search structure used was&#58; &#40;&#40;&#40;&#40;shock index&#41; OR Modified shock index&#41; OR index shock&#41; OR &#40;Diastolic shock index&#41;&#41; AND &#40;&#40;&#40;&#40;&#40;&#40;&#40;&#8220;Sepsis&#8221;&#91;Mesh&#93;&#41; OR &#8220;Sepsis&#8221;&#41; OR septic shock&#41; OR severe sepsis&#41; OR &#8220;Shock&#44; Septic&#8221;&#91;Mesh&#93;&#41; OR septic&#41; OR sepsis septic&#41; Filters&#58; Humans&#46; In the Lilacs database&#44; the structure used was&#58; &#40;&#40;tw&#58;&#40;&#40;tw&#58;&#40;choque septico&#41;&#41; OR &#40;tw&#58;&#40;sepsis&#41;&#41; OR &#40;tw&#58;&#40;septico&#41;&#41; OR &#40;tw&#58;&#40;septicemia&#41;&#41; OR &#40;tw&#58;&#40;sepsis severa&#41;&#41;&#41;&#41; AND &#40;tw&#58;&#40;&#40;tw&#58;&#40;index shock&#41;&#41; OR &#40;tw&#58;&#40;shock index&#41;&#41;&#41;&#41;&#46; A manual search of all references of articles that met the inclusion criteria was also conducted&#44; and sources of grey literature including Google Scholar&#44; OpenGrey&#44; and ClinicalTrials&#46;gov were reviewed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Article selection and data curation</span><p id="par0030" class="elsevierStylePara elsevierViewall">Initially&#44; studies were selected based on titles and abstracts&#46; Studies that initially met the eligibility criteria were read in full text to confirm these criteria&#46; This process was carried out independently by JPC&#44; FD&#44; and JT&#46; Disagreements were assessed by a third author &#40;JJDF&#41; when pertinent&#46; Rayyan software &#40;R&#41; was used for the selection process&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Data curation was performed by 2 authors &#40;JJDF and JPC&#41;&#46; Data about the study objective&#44; methods including the statistical analysis plan and sample size&#44; main results related to the shock index&#44; and conclusions of each study were obtained&#46; An Excel format was designed for this process&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Risk of bias assessment</span><p id="par0040" class="elsevierStylePara elsevierViewall">The risk of bias for each study was determined using the Joanna Briggs Institute &#40;JBI&#41; checklist forms based on each study design&#46; Two authors &#40;JJDF and JPC&#41; applied the tool to the various articles and categorized the overall risk of bias for each study using 3 levels&#58; high&#44; moderate&#44; and low risk&#46; The level of inter-rater agreement was calculated using the Kappa-Cohen test&#44; which was then categorized as null &#40;0&#46;0&#8211;0&#46;2&#41;&#44; low &#40;0&#46;2&#8211;0&#46;4&#41;&#44; moderate &#40;0&#46;4&#8211;0&#46;6&#41;&#44; good &#40;0&#46;6&#8211;0&#46;8&#41;&#44; and very good agreement &#40;0&#46;8&#8211;1&#46;0&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Effect measures</span><p id="par0045" class="elsevierStylePara elsevierViewall">To determine the effect of SI as a prognostic factor in different contexts and outcomes&#44; absolute and relative frequencies mentioned in the text were extracted&#44; as well as the respective measures of central tendency and dispersion&#46; When possible&#44; effect estimators including Odds Ratio &#40;OR&#41;&#44; Relative Risk &#40;RR&#41;&#44; and Hazard Ratio &#40;HR&#41; were extracted according to the context and methodological setting of each study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Ethical considerations</span><p id="par0050" class="elsevierStylePara elsevierViewall">The study was approved by the School of Medicine Research and Ethics Committee of the Health Sciences University Foundation&#44; under Act No&#46; 636 &#40;DI-I-0555-21&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The search identified a total of 601 articles&#44; 67 of which were duplicates&#46; Additionally&#44; 752 articles from grey literature sources were identified&#46; After applying the selection criteria&#44; 337 manuscripts were selected for abstract review&#46; Finally&#44; 17 articles were identified for inclusion in the review &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the characteristics&#44; methodology&#44; and objectives of the included studies&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">All included studies were observational&#44; with only one being prospective&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and 8 &#40;47&#46;1&#37;&#41; being conducted in the ER&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;15&#8211;20</span></a> Sample sizes ranged from 25 to 1266 patients&#46; Twelve articles &#40;70&#46;5&#37;&#41; evaluated the SI&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;21</span></a> 4 evaluated the MSI or DSI&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;23&#44;24</span></a> and 1 study evaluated the SI&#44; MSI&#44; and DSI&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Regarding the risk of bias assessment determined using the JBI tool&#44; two reviewers conducted a paired and independent evaluation of the risk of each included study according to the epidemiological design&#46; There was a statistically significant agreement between the reviewers &#40;p &#60; 0&#46;001&#41;&#59; however&#44; the level of this agreement was low &#40;0&#46;286&#41;&#46; We found that all included articles presented a &#8220;low risk&#8221; assessment in 60&#37; or more of the content of each&#46; Concerns identified in the included studies according to their design revealed deficiencies in the identification and management of confounding factors in cross-sectional&#44; case-control&#44; and cohort studies&#46; Additionally&#44; in cohort studies&#44; further concerns were identified related to strategies employed to address incomplete follow-up in some cases&#46; The risk of bias assessment for the studies is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Among the studies that evaluated the prognostic value of SI&#44; 4 showed statistically significant differences between the admission SI value in the survivor vs the non-survivors group&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;14&#44;15&#44;17</span></a> and one more in the evaluation of SI before the initiation of vasopressors&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Two more studies showed favorable results between the average of several SI measures in the emergency department or the variation of prehospital SI and clinical outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;21</span></a> In contrast&#44; in 4 studies&#44; prehospital SI&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a> admission SI&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> or the average SI within the first 6 hours were not associated with mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> See <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Among the 3 studies that evaluated the MSI&#44; 2 showed a favorable relationship with clinical outcomes such as myocardial depression<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> while 1 was not associated with mortality whatsoever&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Three other studies that evaluated the DSI showed a relationship with mortality<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;22</span></a> and the dose of dobutamine received&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> It is important to note that Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> conducted several statistical adjustment models to determine the association between DSI and mortality&#46; Among them&#44; only the model adjusted for age&#44; sex&#44; race&#44; and ICU management was significant&#46; However&#44; when also adjusting for SOFA scale values&#44; it was evident that DSI was not associated with mortality in hospitalized patients&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarizes the studies with prognostic evaluation of the MSI and DSI values in the septic shock population&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; two studies evaluated the response of SI to certain medical interventions&#46; Lanspa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> demonstrated that a CVP &#8805; 8 mmHg had an NPV of 83&#37; for predicting fluid response&#44; while for SI &#8804; 1&#44; it was 88&#37;&#44; and for the combination of CVP &#8805; 8 &#43; SI &#8804; 1&#44; the NPV increased to 93&#37;&#46; Al Aseri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> showed a lower SI in patients who responded to fluid management vs those who did not&#44; with a SI &#61; 1&#46;03 &#40;0&#46;3&#41; beats&#47;min&#47;mmHg vs 1&#46;28 &#40;0&#46;5&#41;&#44; respectively&#44; p &#61; 0&#46;007&#46; An SI &#8805; 0&#46;875 had a sensitivity of 81&#37; and specificity of 72&#37; to predict poor response to fluids and the need to initiate norepinephrine&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The present systematic review demonstrates that the IS has been studied in recent years in the context of patients with septic shock&#44; showing potential value in prognosis and utility for fluid management&#46; The main feature of this variable is its easy measurement&#44; allowing it to be obtained in any hospital care setting and repeated as often as necessary&#44; which is important for close monitoring and follow-up of patients with this disease&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">When analyzing the studies that evaluated the prognostic value of the variable&#44; we observed that the results were inconsistent&#46; Several aspects must be considered in this regard&#46; First&#44; the method of evaluating prognosis varied&#59; in some studies&#44; the IS was assessed as a continuous variable&#44; yielding median and mean differences&#44; while in other cases&#44; it was assessed as a categorical variable&#44; resulting in different outcomes depending on the type of analysis&#46; Second&#44; when analyzed as a categorical variable&#44; choosing the cutoff point is crucial&#46; Studies conducted on IS in patients with other pathologies use different cutoff points&#44; some to define normality and others to establish cutoffs related to prognosis&#46; Values from 0&#46;5 to 1&#46;3 beats&#47;min&#47;mmHg have been used&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;25</span></a> This wide range of values was seen in our results&#46; This aspect affects the operational performance of the IS in different evaluations&#44; making it difficult to compare studies&#46; Third&#44; some of the included studies did not show statistically significant differences in their results&#44; possibly due to the small sample size in some or the clinical heterogeneity of the patients given the complexity of each case&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13&#44;19</span></a> Specifically&#44; in the study by Jouffroy et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> an IS &#62; 1 was observed in 57&#37; of non-survivors vs 32&#37; of survivors &#40;p &#61; 0&#46;21&#41;&#46; Even though the p-value does not show statistical significance&#44; the percentage difference can be considered important from a clinical perspective&#46; Therefore&#44; &#8220;statistical significance&#8221; for exclusive reasons of p-values should not preclude the interpretation or clinical importance of a result&#46; Additionally&#44; while clinical relevance is crucial&#44; it is important to recognize that some studies&#44; after applying statistical adjustments for possible confounding variables&#44; indicate a lack of association between various iterations of the IS and in-hospital mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Consequently&#44; when interpreting the results&#44; it is recommended to exercise special caution and consider both clinical utility and the statistical tools applied&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The temporal progression of physiological variables during the resuscitation of a patient with septic shock is of high importance&#46; The so-called &#8220;lactate clearance&#8221; is the classic example&#44; in which the percentage reduction of lactate during the first hours of resuscitation is evaluated&#46; This variable has shown an important relationship with the patient&#39;s prognosis<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> and is recommended as a therapeutic goal by the latest Surviving Sepsis Campaign guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In this regard&#44; various studies have shown the importance of the temporal evolution of the IS&#46; Wira et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> demonstrated a worse prognosis in patients who maintained a sustained elevation of the IS during resuscitation at the ER&#46; Mohamed et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> showed greater importance of the IS measurement two hours after ICU admission vs the admission measurement&#44; similar to Yussof et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> who showed a higher AUC for mortality of the IS measured 2 hours after the ER admission vs the admission IS&#44; while Ospina et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> showed that the IS decreased significantly in the survivor vs to non-survivors group&#44; and Xiao et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> showed that the mean IS measured 3 hours after resuscitation was higher in non-survivors vs survivors&#44; with a higher AUC for prognosis evaluation&#46; Similarly&#44; Jouffroy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> incorporated the IS delta as an independent variable for predicting the 28-day mortality rate&#46; Interestingly&#44; the authors concluded that a negative IS delta could help physicians identify patients with severe sepsis and septic shock at a higher risk regarding the 28-day mortality rate&#46; This type of analysis suggests that this measure should be used repeatedly during initial resuscitation&#44; paying special attention to patients who do not show a decrease in the variable&#44; indicating the need for closer monitoring and adjustment in management if possible&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Regarding the clinical and hemodynamic response to IV fluid volume&#44; Monnet et al&#46; reported that in a group of 37 patients&#44; a 10&#37; increase in stroke volume or a 15&#37; increase in pulse pressure were highlighted as simple and significant clinical indicators for predicting fluid responsiveness in critically ill patients during passive leg raising&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The IS was also investigated during fluid administration maneuvers&#46; Mohamed et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> provided data showing a decrease in IS measured 15 minutes after fluid administration in both survivors and non-survivors&#44; without observing significant differences between both groups&#46; Lanspa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> conducted an interesting study showing how the combined measurement of CVP with IS identifies those labeled as &#8220;non-responders to fluids&#8221;&#44; patients who do not increase cardiac output by more than 15&#37; after a fluid challenge in a short time &#40;fluid challenge&#41;&#46; This is important&#44; considering that identifying this &#8220;response&#8221; is seen as fundamental to managing these patients and is part of the recommendations of the current Surviving Sepsis Campaign guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which require the use of special monitoring that is not always available in all patient care units&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a> Al Aseri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> evaluated the IS to estimate a cutoff point that identifies the patient with hemodynamic collapse who will require vasopressors&#44; with an IS &#62; 0&#46;87 identifying the patient who will not respond to fluids&#44; meaning they will require vasopressors&#44; with greater specificity and sensitivity&#46; Similarly&#44; according to Razazi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> the IS could function as a clinical marker of response to dobutamine resuscitation in patients with septic cardiomyopathy&#44; regardless of the dose used&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In 3 studies&#44; the DSI was evaluated&#44; an index presented not only as a variable contributing to patient prognosis but also as one with potential utility in patient management as it can identify patients requiring early vasopressor intervention&#44; an important concept today&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> The proposal is based on the fact that the loss of arterial elastance is a key element in the pathophysiology of circulatory compromise in septic shock&#46; This condition leads to a decrease in DBP and&#44; therefore&#44; a compromised DSI&#46; Ospina et al&#46; identified that the risk of higher mortality was more clearly identified with DSI rather than IS or DBP&#44; suggesting that this index could be used as a variable to define interventions in the management of these patients&#46; These hypotheses on the potential clinical use of IS and DSI in management algorithms should be evaluated in studies designed for this purpose&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The limitations of IS are notable due to its static nature&#44; which makes it difficult to objectively evaluate the clinical and hemodynamic progression of patients from their admission and during treatment&#46; Additionally&#44; IS is problematic for assessing the effect of volume administration on cardiac output&#44; as other clinical variables can modify blood pressure readings&#44; indirectly affecting the IS value&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">33&#8211;35</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Moreover&#44; it is important to note that fluid responsiveness does not guarantee better oxygen consumption&#46; It is estimated that only about half &#40;56&#37;&#41; of patients who respond to fluids experience an increase in their oxygen consumption&#46; Therefore&#44; even if there are increases in blood pressure or even cardiac output&#44; this does not necessarily guarantee an increase in tissue perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> For this reason&#44; it is suggested that IS should be integrated into fluid resuscitation protocols in septic patients&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">IS has been frequently studied in patients with septic shock&#59; few studies have been identified with other versions of IS&#46; The results suggest that both IS and its modified versions in single and serial evaluations can be considered for evaluating patient prognosis&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Our study presents several limitations&#46; First&#44; all studies&#44; except for one&#44; are retrospective&#44; which is associated with certain biases inherent to these designs&#44; mainly confounding bias&#46; Second&#44; there is notable clinical heterogeneity in the presentation and measurement of the variables of interest&#44; including variability in the timing of measurement during the length of stay and the different contexts and places where the variables are determined&#44; such as emergency services&#44; hospitalization wards&#44; and intensive care units&#46; Additionally&#44; there are other potentially confounding factors&#44; such as comorbidities&#44; the patients&#8217; baseline clinical status&#44; and the use of pharmacological therapies&#46; Third&#44; the lack of consistency in study selection criteria limits the generalization of the results to the entire population&#46; Due to the above-mentioned limitations&#44; it is not appropriate to perform a meta-analysis of the results&#44; which prevents providing a weighted effect estimator&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Authors&#8217; contributions</span><p id="par0145" class="elsevierStylePara elsevierViewall">Conceptualization&#58; JJDF&#44; JPCG&#44; MASO&#46; Data mining and management&#58; JJDF&#44; JPCG&#44; MASO&#44; JITZ&#44; FEDM&#46; Data analysis&#58; JJDF&#44; JPCG&#46; Project administration&#58; JJDF&#46; Manuscript writing &#40;original draft&#41;&#58; JJDF&#44; JPCG&#46; Manuscript review and editing&#58; JJDF&#44; JPCG&#44; MASO&#44; JITZ&#44; FEDM&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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    "fechaAceptado" => "2024-06-23"
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      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1853109"
          "palabras" => array:5 [
            0 => "Sepsis"
            1 => "Septic shock"
            2 => "Lactate"
            3 => "Shock index"
            4 => "Resuscitation"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1853110"
          "palabras" => array:5 [
            0 => "Sepsis"
            1 => "Choque s&#233;ptico"
            2 => "Lactato"
            3 => "&#205;ndice de shock"
            4 => "Reanimaci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To identify published research on the Shock Index &#40;SI&#41; in patients with septic shock or severe sepsis and to describe its main findings and conclusions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Systematic review of the literature following the recommendations of the PRISMA protocol &#40;Preferred Reporting Items for Systematic Reviews and Meta-Analyses&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Settings</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The following databases were consulted&#58; Pubmed&#44; Embase&#44; Library Cochrane and Lilacs&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patients older than 14 years with septic shock&#46; Pregnant women and population with COVID-19 were excluded&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Studies reporting measurement of the shock index or its modified variants&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Main variables of interest</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Absolute frequencies and relative frequencies were assessed with measures of central tendency and dispersion&#46; Effect estimators &#40;OR&#44; RR and HR&#41; were extracted according to the context of each study&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Seventeen articles were included&#44; of which 11 investigated the SI as a predictor of mortality&#46; Seven of them found significant differences in the SI when comparing survivors to non-survivors and observed a relationship between the SI evolution and clinical outcomes&#46; Additional research evidenced a relation between the Modified Shock Index and myocardial depression&#44; as well as mortality&#46; Furthermore&#44; they identified a relationship between the Diastolic Shock Index&#44; the dose of administered dobutamine&#44; and mortality&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">The results suggest that both the SI and its modified versions&#44; particularly in serial assessments&#44; can be considered for evaluating patient prognosis&#46; The SI can also aid in determining fluid management for patients&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Design"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Settings"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Patients"
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          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Interventions"
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          5 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Main variables of interest"
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          6 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
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          7 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
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      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Identificar las investigaciones publicadas sobre el &#205;ndice de Shock &#40;IS&#41; en pacientes con choque s&#233;ptico o sepsis severa y describir sus principales resultados y conclusiones&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Dise&#241;o</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n sistem&#225;tica de la literatura siguiendo las recomendaciones del protocolo PRISMA &#40;Preferred Reporting Items for Systematic Reviews and Meta-Analyses&#41;&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">&#193;mbito</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Se consultaron las bases de datos&#58; Pubmed&#44; Embase&#44; Library Cochrane y Lilacs&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Pacientes mayores de 14 a&#241;os con choque s&#233;ptico&#46; Se excluyeron mujeres embarazadas y poblaci&#243;n con COVID-19&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Estudios que reportaran la medici&#243;n del &#237;ndice de choque o sus variantes modificadas&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables de inter&#233;s principales</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron frecuencias absolutas y frecuencias relativas con medidas de tendencia central y dispersi&#243;n&#46; Se extrajeron estimadores de efecto &#40;OR&#44; RR y HR&#41; seg&#250;n el contexto de cada estudio&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 17 art&#237;culos&#44; de los cuales 11 investigaron el IS como un predictor de mortalidad&#46; 7 encontraron diferencias significativas en el IS al comparar supervivientes de no supervivientes&#44; y observaron una relaci&#243;n entre la evoluci&#243;n del IS y los resultados cl&#237;nicos&#46; Investigaciones adicionales evidenciaron una relaci&#243;n entre el &#205;ndice de Shock Modificado y la depresi&#243;n mioc&#225;rdica&#44; as&#237; como con la mortalidad&#46; Adem&#225;s&#44; identificaron una relaci&#243;n entre el &#205;ndice de Shock Diast&#243;lico&#44; la dosis de dobutamina administrada y la mortalidad&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Los resultados sugieren que tanto el IS como sus versiones modificadas&#44; principalmente en evaluaciones seriadas&#44; pueden ser tenidos en cuenta para evaluar el pron&#243;stico del paciente&#46; El IS tambi&#233;n puede ser &#250;til en definir el uso de l&#237;quidos en los pacientes&#46;</p></span>"
        "secciones" => array:8 [
          0 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Dise&#241;o"
          ]
          2 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "&#193;mbito"
          ]
          3 => array:2 [
            "identificador" => "abst0060"
            "titulo" => "Pacientes"
          ]
          4 => array:2 [
            "identificador" => "abst0065"
            "titulo" => "Intervenciones"
          ]
          5 => array:2 [
            "identificador" => "abst0070"
            "titulo" => "Variables de inter&#233;s principales"
          ]
          6 => array:2 [
            "identificador" => "abst0075"
            "titulo" => "Resultados"
          ]
          7 => array:2 [
            "identificador" => "abst0080"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flowchart of identification&#44; evaluation&#44; and eligibility conducted in this systematic review&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Averaged risk of bias assessment by 2 independent reviewers&#44; according to the Joanna Briggs Institute recommendations<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> adjusted to each epidemiological design&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SI&#58; shock index&#59; ICU&#58; intensive care unit&#59; MSI&#58; modified shock index&#59; DSI&#58; diastolic shock index&#59; SIGARC&#58; shock index &#8805; 1&#59; Glasgow coma scale &#60; 13&#59; age &#62; 65&#59; respiratory rate &#62; 22&#59; Comorbidity&#59; PSPoT&#58; prehospital shock precautions on triage&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Author and year of publication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Methodological aspects &#40;study location&#44; n and design&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study objective related to SI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lanspa MJ&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICU of shock&#47;trauma and respiratory&#46;N &#61; 25Prospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the combination of SI and central venous pressure among fluid responders and non-responders&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yussof S&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 50Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Determine the prognostic value of SI measured upon arrival at the ER and 2 hours after IV fluid resuscitation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wira C&#46; et al&#46; &#40;2014&#41;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 295Cross-sectional&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate sustained elevation of SI as a predictor of short-term cardiovascular collapse&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mohamed A&#46; et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical ICUN &#61; 58Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate changes in SI&#44; vascular permeability index&#44; and lactate&#47;pyruvate ratio in response to fluid challenge&#44; and their relation to ICU survival and non-invasive monitoring predictability&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jayaprakash N&#46; et al&#46; &#40;2017&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 578Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Explore the association of elevated MSI and myocardial dysfunction&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wu A&#46; et al&#46; &#40;2018&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 127Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the correlation between SI and severity and prognostic values&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 114Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between SI and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ospina-Tasc&#243;n G&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 761Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate MSI and clinical outcomes&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Al Aseri Z&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emergency Department N &#61; 98 Cross-sectional&#44; Single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the utility of SI as a predictive tool for poor response to IV fluid management&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xiao J&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 154Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observe the correlation among SI&#44; pulmonary vascular permeability index&#44; and clinical severity&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 406Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between SI&#44; prehospital SIGARC score&#44; and in-hospital mortality at 30 and 90 days&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 181Prospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between the prehospital PSPoT score and hospital mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lee S&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 340Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observe the association between time-weighted mean hemodynamic parameters during initial resuscitation and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prehospital mobile ICUN &#61; 406Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the association between prehospital SI variation and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 1266Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the relationship between SI&#44; MSI&#44; and DSI with 3-day mortality and initiation of vasopressors&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#225;nchez-D&#237;az JS&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 60Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the association between MSI and in-hospital mortality in patients with sepsis of abdominal origin&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Razazi K&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 32Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Characterize the hemodynamic response&#44; including DSI in patients with septic cardiomyopathy on dobutamine&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Descriptive data of included studies&#46;</p>"
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          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">SI&#58; shock index&#59; AUC&#58; area under the ROC Curve&#59; OR&#58; odds ratio&#59; PPV&#58; positive predictive value&#59; NPV&#58; negative predictive value&#59; HR&#58; hazard ratio&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lead author&#44; year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Main Results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yussof S&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- SI at admission and in-hospital mortality&#58;Survivors &#61; 1&#46;2Deceased &#61; 1&#46;4&#44; p &#61; 0&#46;009<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1 two hours post-admission&#58;</span></span>Sensitivity &#61; 80&#46;8&#37;&#44; Specificity &#61; 79&#46;2&#37;&#44; AUC &#61; 0&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wira C&#46; et al&#46; &#40;2014&#41;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Sustained SI elevation &#62; 0&#46;8 during more than 80&#37; of vital sign measurements at the ER and clinical outcomes</span></span>&#58;Higher vasopressor requirement &#40;OR&#44; 4&#46;42&#44; 95&#37; CI&#44; 2&#46;28&#8211;8&#46;55&#41; and a greater number of total organ failures cs the group without such sustained elevation &#40;4&#46;0 &#177; 2&#46;1 vs 3&#46;2 &#177; 1&#46;6&#44; p &#61; 0&#46;0001&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mohamed A&#46; et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and hospital mortality&#58;</span></span>Survivors &#61; 0&#46;89Deceased &#61; 1&#46;05&#44; p &#62; 0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wu A&#46; et al&#46; &#40;2018&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;35 &#177; 0&#46;32Deceased &#61; 1&#46;62 &#177; 0&#46;46 &#40;p &#60; 0&#46;01&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI 3 hours post-admssion and 28-day mortality&#58;</span></span>Survivors &#61; 0&#46;93 &#177; 0&#46;15Deceased &#61; 1&#46;36 &#177; 0&#46;24 &#40;p &#60; 0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and in-hospital mortality&#58;</span></span>Survivors &#61; 0&#46;73 &#40;0&#46;61&#8211;1&#46;00&#41;Deceased &#61; 0&#46;80 &#40;0&#46;66&#8211;1&#46;10&#41;&#44; p &#60; 0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xiao J&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;36 &#177; 0&#46;31Deceased &#61; 1&#46;63 &#177; 0&#46;29 &#40;p &#60; 0&#46;001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1&#46;72&#58;</span></span>Sensitivity &#61; 91&#46;2&#37;&#44; Specificity &#61; 89&#46;4&#37;&#44; PPV &#61; 0&#46;91&#44; NPV &#61; 0&#46;92<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI 3 hours post-admission&#58;</span></span>Survivors &#61; 0&#46;92 &#177; 0&#46;14Deceased &#61; 1&#46;37 &#177; 0&#46;13 &#40;p &#60; 0&#46;001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1&#46;22&#58;</span></span>Sensitivity &#61; 90&#46;1&#37;&#44; Specificity &#61; 85&#46;7&#37;&#44; PPV &#61; 0&#46;89&#44; NPV &#61; 0&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI and in-hospital mortality&#58;</span></span>Survivors &#61; 1&#46;1 &#177; 0&#46;5Deceased &#61; 1&#46;1 &#177; 0&#46;5&#44; p &#61; 0&#46;706&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI &#62; 1 and in-hospital mortality&#58;</span></span>Survivors&#44; n &#61; 38 &#40;32&#37;&#41;Deceased&#44; n &#61; 28 &#40;28&#37;&#41;&#44; p &#61; 0&#46;213&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lee S&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Mean SI within the first 6 hours and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;06Deceased &#61; 1&#46;06&#44; p &#61; 0&#46;244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI delta and 28-day mortality&#58;</span></span>Negative delta HR&#44; 1&#46;88 &#40;95&#37; CI&#44; 1&#46;07&#8211;3&#46;31&#41; &#40;p &#61; 0&#46;03&#41;Positive delta HR&#44; 0&#46;53 &#40;95&#37; CI&#44; 0&#46;30&#8211;0&#46;94&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI before the start of vasopressors and 3-day mortality&#58;</span></span>Average SI &#61; 1&#46;32 vs 0&#46;64 OR&#44; 6&#46;43 &#40;95&#37; CI&#44; 3&#46;26&#8211;14&#46;22&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SI&#59; shock index&#58; MSI&#59; modified shock index&#58; DSI&#59; diastolic shock index&#58; AUC&#59; area under the ROC Curve&#58; OR&#59; odds ratio&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lead author&#44; year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Main results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Jayaprakash N&#46; et al&#46; &#40;2017&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI with dysfunction and myocardial depression&#58;</span></span>AUC of various measurements within the first 6 hours and myocardial depression&#58; OR&#44; 1&#46;28&#44; 95&#37; CI&#44; 1&#46;07&#8211;1&#46;53&#44; p &#61; 0&#46;007&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ospina-Tasc&#243;n G&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI before the start of vasopressors and 90-day mortality&#58;</span></span>RR increased between quintile 1 &#40;Q1&#41; and quintile 5 &#40;Q5&#41; &#40;p &#60; 0&#46;001&#41;Decrease wihtin the first 8 hours of resuscitation among survivors vs non-survivors&#44; p &#60; 0&#46;001&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI before the start of vasopressors and 3-day mortality&#58;</span></span>Range&#44; fourth quartile IS &#61; 1&#46;64&#8211;5&#46;78 vs Range&#44; first quartile IS &#61; 0&#46;44&#8211;1&#46;12OR&#44; 3&#46;78 &#40;95&#37; CI&#44; 2&#46;05&#8211;7&#46;45&#41; &#40;p &#60; 0&#46;0001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI before the start of vasopressors and 3-day mortality&#58;</span></span>Range&#44; fourth quartile IS &#61; 1&#46;96&#8211;11&#46;9 vs Range&#44; first quartile IS &#61; 0&#46;46&#8211;1&#46;35OR&#44; 4 &#40;95&#37; CI&#44; 2&#46;18&#8211;7&#46;86&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#225;nchez-D&#237;az JS&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI at admission &#62; 1&#46;3 and in-hospital mortality&#58;</span></span>Survivors&#44; n &#61; 26 &#40;83&#46;9&#37;&#41;Deceased&#44; n &#61; 24 &#40;82&#46;8&#37;&#41;&#44; p &#61; 0&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Razazi et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI and dobutamine dose&#58;</span></span>0 mcg&#47;kg&#47;min&#44; DSI &#61; 1&#46;7 &#40;1&#46;4&#8211;1&#46;0&#41;&#8805; 5 mcg&#47;kg&#47;min&#44;DSI &#61; 2&#46;1 &#40;1&#46;7&#8211;2&#46;7&#41; &#40;p &#60; 0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Prognostic evaluation of MSI and DSI values in septic shock population&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:36 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shock index&#58; a re-evaluation in acute circulatory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;Y&#46; Rady"
                            1 => "P&#46; Nightingale"
                            2 => "R&#46;A&#46; Little"
                            3 => "J&#46;D&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0300-9572(92)90006-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Resuscitation"
                        "fecha" => "1992"
                        "volumen" => "23"
                        "paginaInicial" => "227"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1321482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shock index as a predictor for mortality in trauma patients&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Vang"
                            1 => "M&#46; &#216;stberg"
                            2 => "J&#46; Steinmetz"
                            3 => "L&#46;S&#46; Rasmussen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00068-022-01932-z"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Trauma Emerg Surg"
                        "fecha" => "2022"
                        "volumen" => "48"
                        "paginaInicial" => "2559"
                        "paginaFinal" => "2566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35258641"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674922014774"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shock index predicts outcome in patients with suspected sepsis or community-acquired pneumonia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Smith Middleton"
                            1 => "Neilly Bedford"
                            2 => "Myint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/jcm8081144"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Med"
                        "fecha" => "2019"
                        "volumen" => "8"
                        "paginaInicial" => "1144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31370356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilizaci&#243;n del &#237;ndice de shock en el manejo de pacientes con sepsis severa y choque s&#233;ptico&#58; una revisi&#243;n sistem&#225;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;J&#46; Diaztagle Fern&#225;ndez"
                            1 => "W&#46;A&#46; G&#243;mez N&#250;&#241;ez"
                            2 => "M&#46; Plazas Vargas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Colomb Cuid Intensivo"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "262"
                        "paginaFinal" => "269"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated modified shock index in early sepsis is associated with myocardial dysfunction and mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Jayaprakash"
                            1 => "O&#46; Gajic"
                            2 => "R&#46;D&#46; Frank"
                            3 => "N&#46; Smischney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcrc.2017.08.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2018"
                        "volumen" => "43"
                        "paginaInicial" => "30"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28843067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic shock index and clinical outcomes in patients with septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Ospina-Tasc&#243;n"
                            1 => "J&#46;L&#46; Teboul"
                            2 => "G&#46; Hernandez"
                            3 => "I&#46; Alvarez"
                            4 => "A&#46;I&#46; S&#225;nchez-Ortiz"
                            5 => "L&#46;E&#46; Calder&#243;n-Tapia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13613-020-00658-8"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Intensive Care"
                        "fecha" => "2020"
                        "volumen" => "10"
                        "paginaInicial" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32296976"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surviving sepsis campaign&#58; international guidelines for management of sepsis and septic shock 2021"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Evans"
                            1 => "A&#46; Rhodes"
                            2 => "W&#46; Alhazzani"
                            3 => "M&#46; Antonelli"
                            4 => "C&#46;M&#46; Coopersmith"
                            5 => "C&#46; French"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-021-06506-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2021"
                        "volumen" => "47"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34599691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rayyan&#8212;a web and mobile app for systematic reviews"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ouzzani"
                            1 => "H&#46; Hammady"
                            2 => "Z&#46; Fedorowicz"
                            3 => "A&#46; Elmagarmid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13643-016-0384-4"
                      "Revista" => array:5 [
                        "tituloSerie" => "Syst Rev"
                        "fecha" => "2016"
                        "volumen" => "5"
                        "paginaInicial" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27919275"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "JBI&#8217;s systematic reviews"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Z&#46; Munn"
                            1 => "C&#46; Tufanaru"
                            2 => "E&#46; Aromataris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.NAJ.0000451683.66447.89"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJN&#44; Am J Nurs"
                        "fecha" => "2014"
                        "volumen" => "114"
                        "paginaInicial" => "49"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25742352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central venous pressure and shock index predict lack of hemodynamic response to volume expansion in septic shock&#58; a prospective&#44; observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Lanspa"
                            1 => "S&#46;M&#46; Brown"
                            2 => "E&#46;L&#46; Hirshberg"
                            3 => "J&#46;P&#46; Jones"
                            4 => "C&#46;K&#46; Grissom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "609"
                        "paginaFinal" => "615"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of Shock Index in prognosticating the short-term outcome of death for patients presenting with severe sepsis and septic shock in the emergency department"
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                          "etal" => false
                          "autores" => array:6 [
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                            3 => "M&#46;A&#46; Bujang"
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                            5 => "A&#46;H&#46; Asaari"
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                        "tituloSerie" => "Med J Malaysia"
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                        "paginaInicial" => "406"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "The shock index as a predictor of vasopressor use in emergency department patients with severe sepsis"
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                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Wira"
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                            2 => "S&#46; Bhat"
                            3 => "R&#46; Ehrman"
                            4 => "D&#46; Conner"
                            5 => "M&#46; Siegel"
                          ]
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                    0 => array:2 [
                      "doi" => "10.5811/westjem.2013.7.18472"
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                        "tituloSerie" => "West J Emerg Med"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "60"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24696751"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Disturbed fluid responsiveness and lactate&#47;pyruvate ratio as predictors for mortality of septic shock patients"
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                          "etal" => false
                          "autores" => array:2 [
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                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Egypt J Anaesth"
                        "fecha" => "2016"
                        "volumen" => "32"
                        "paginaInicial" => "451"
                        "paginaFinal" => "461"
                      ]
                    ]
                  ]
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              "identificador" => "bib0070"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Correlation between shock index and severity of septic shock and its prognostic value"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Wu"
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                            2 => "F&#46; Han"
                            3 => "Y&#46; Ni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3760/cma.j.issn.2095-4352.2018.012.008"
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                        "tituloSerie" => "Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"
                        "fecha" => "2018"
                        "volumen" => "30"
                        "paginaInicial" => "1141"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30592947"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prehospital shock index to assess 28-day mortality for septic shock"
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                            0 => "R&#46; Jouffroy"
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                            2 => "P&#46; Gueye"
                            3 => "E&#46; Bloch-Laine"
                            4 => "V&#46; Bounes"
                            5 => "G&#46; Debaty"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Emerg Med"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The use of the shock index to predict hemodynamic collapse in hypotensive sepsis patients&#58; a cross-sectional analysis"
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                          "etal" => false
                          "autores" => array:3 [
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                            2 => "M&#46; Binkharfi"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/sja.SJA_780_19"
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                        "tituloSerie" => "Saudi J Anaesth"
                        "fecha" => "2020"
                        "volumen" => "14"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32317874"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Correlation between pulmonary vascular permeability index&#44; shock index&#44; and severity of septic shock and their evaluation values for prognosis"
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                            2 => "Y&#46; Guo"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Iran Red Crescent Med J"
                        "fecha" => "2020"
                        "volumen" => "22"
                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
                      ]
                    ]
                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The prehospital SIGARC score to assess septic shock in-hospital&#44; 30-day and 90-day mortality"
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                          "etal" => true
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                            3 => "E&#46; Bloch-Laine"
                            4 => "P&#46; Ecollan"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajem.2020.10.014"
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                        "tituloSerie" => "Am J Emerg Med"
                        "fecha" => "2021"
                        "volumen" => "46"
                        "paginaInicial" => "355"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34348435"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0095"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Prehospital Shock Precautions on Triage &#40;PSPoT&#41; score to assess in-hospital mortality for septic shock"
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                            5 => "P&#46; Gueye-Ngalgou"
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                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy"
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                          "etal" => false
                          "autores" => array:5 [
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                            1 => "Y&#46;J&#46; Kim"
                            2 => "G&#46;N&#46; Yu"
                            3 => "J&#46;C&#46; Jeon"
                            4 => "W&#46;Y&#46; Kim"
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                        ]
                      ]
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                  ]
                  "host" => array:1 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "Korean J Intern Med"
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                        "volumen" => "36"
                        "paginaInicial" => "924"
                        "paginaFinal" => "931"
                      ]
                    ]
                  ]
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              "identificador" => "bib0105"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between prehospital shock index variation and 28-day mortality among patients with septic shock"
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                            1 => "B&#46; Gilbert"
                            2 => "L&#46; Thomas"
                            3 => "E&#46; Bloch-Laine"
                            4 => "P&#46; Ecollan"
                            5 => "J&#46; Boularan"
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                      "doi" => "10.1186/s12873-022-00645-1"
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                        "tituloSerie" => "BMC Emerg Med"
                        "fecha" => "2022"
                        "volumen" => "22"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35590250"
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              "identificador" => "bib0110"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Evaluation of SI&#44; MSI and DSI for very early &#40;3-day&#41; mortality in patients with septic shock"
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                            2 => "S&#46;Y&#46; Gao"
                            3 => "C&#46;F&#46; Liu"
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                        "tituloSerie" => "Eur J Med Res"
                        "fecha" => "2022"
                        "volumen" => "27"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36329534"
                            "web" => "Medline"
                          ]
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              ]
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              "identificador" => "bib0115"
              "etiqueta" => "23"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simplified acute physiology score II and Mannheim peritonitis index are associated with in-hospital mortality in patients with abdominal sepsis admitted to ICU"
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                        0 => array:2 [
                          "etal" => true
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                            5 => "K&#46;G&#46; Peniche-Moguel"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cir Cir"
                        "fecha" => "2022"
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                          "estado" => "S300"
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              "identificador" => "bib0120"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic effects and tolerance of dobutamine for myocardial dysfunction during septic shock&#58; An observational multicenter prospective echocardiographic study"
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                        0 => array:2 [
                          "etal" => true
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                            4 => "G&#46; Carteaux"
                            5 => "N&#46; de Prost"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Front Cardiovasc Med"
                        "fecha" => "2022"
                        "volumen" => "9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Review article&#58; Shock Index for prediction of critical bleeding post&#8208;trauma&#58; a systematic review"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "B&#46; Mitra"
                            3 => "M&#46; Fitzgerald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Emerg Med Australas"
                        "fecha" => "2014"
                        "volumen" => "26"
                        "paginaInicial" => "223"
                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24712642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood lactate levels in sepsis&#58; in 8 questions"
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                        0 => array:2 [
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                          "autores" => array:2 [
                            0 => "J&#46;L&#46; Vincent"
                            1 => "J&#46; Bakker"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0000000000000824"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2021"
                        "volumen" => "27"
                        "paginaInicial" => "298"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33852499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Porcentajes de cambio del lactato en pacientes con choque s&#233;ptico tard&#237;o&#46; Un an&#225;lisis de pacientes individuales"
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                        0 => array:2 [
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                            3 => "J&#46;I&#46; Alvarado S&#225;nchez"
                            4 => "J&#46;A&#46; Navarrete Ria&#241;o"
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                          ]
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Colomb Cuid Intensivo"
                        "fecha" => "2021"
                        "volumen" => "21"
                        "paginaInicial" => "33"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
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              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Passive leg raising predicts fluid responsiveness in the critically ill&#42;"
                      "autores" => array:1 [
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                            0 => "X&#46; Monnet"
                            1 => "M&#46; Rienzo"
                            2 => "D&#46; Osman"
                            3 => "N&#46; Anguel"
                            4 => "C&#46; Richard"
                            5 => "M&#46;R&#46; Pinsky"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.CCM.0000215453.11735.06"
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                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "34"
                        "paginaInicial" => "1402"
                        "paginaFinal" => "1407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16540963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of fluid responsiveness&#46; What&#8217;s new&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Monnet"
                            1 => "R&#46; Shi"
                            2 => "J&#46;L&#46; Teboul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13613-022-01022-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intensive Care"
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Original article
Assessment of the shock index in septic shock: A systematic review
Evaluación del índice de shock en choque séptico: una revisión sistemática
Juan José Diaztagle Fernándeza,
Corresponding author
jjdiaztagle@fucsalud.edu.co

Corresponding author.
, Juan Pablo Castañeda-Gonzálezb, José Ignacio Trujillo Zambranoc, Francy Esmith Duarte Martínezc, Miguel Ángel Saavedra Ortizc
a Servicio de Medicina Interna, Fundación Universitaria de Ciencias de la Salud – FUCS, Hospital de San José de Bogotá. Departamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia
b Semillero de Investigación en Medicina Interna, Fundación Universitaria de Ciencias de la Salud – FUCS, Bogotá, Colombia
c Servicio de Medicina de Urgencias, Fundación Universitaria de Ciencias de la Salud – FUCS, Bogotá, Colombia
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        "titulo" => "Evaluaci&#243;n del &#237;ndice de <span class="elsevierStyleItalic">shock</span> en choque s&#233;ptico&#58; una revisi&#243;n sistem&#225;tica"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The Shock Index &#40;SI&#41; is defined as the ratio between heart rate &#40;HR&#41; and systolic blood pressure &#40;SBP&#41;&#46; This index is a simple and quick measure that is part of the initial evaluation of a patient&#8217;s hemodynamic status in emergency settings&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and is primarily used in patients with hemorrhagic shock&#44; where it has been associated with various clinical outcomes or tissue perfusion parameters&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although it has an easily understandable physiological rationale&#44; few studies have explored its measurement in patients diagnosed with sepsis or septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> A previous systematic review identified only five publications that evaluated SI in patients with septic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> However&#44; in recent years&#44; new studies have been published that continue to highlight the importance of this index in prognosis&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and recently other forms of evaluating SI have been described&#44; such as the Modified Shock Index &#40;MSI&#41; and the Diastolic Shock Index &#40;DSI&#41;&#44; considering the pathophysiological basis of sepsis&#44; with results suggesting a benefit in using it as a prognostic tool and potentially for the management of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The latest version of the Surviving Sepsis Campaign &#40;SSC&#41; recommends measuring mean arterial pressure and establishes a therapeutic target for this measure during the initial management of patients with septic shock&#46; Additionally&#44; they suggest measuring blood lactate and capillary refill time as a way to evaluate tissue perfusion status&#44; recommending their normalization when altered&#46; Although other hemodynamic and tissue perfusion variables have been investigated&#44; the SSC does not offer recommendations on evaluating other types of physiological variables&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> SI may be a useful measure to complement patient care&#44; particularly due to its ease of measurement in any medical care setting&#46; The objective of this review is to determine the association of SI and its various derivatives with clinical outcomes and mortality in patients with septic shock&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patients and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We conducted a systematic literature review&#44; including observational studies &#40;cohorts&#44; case-controls&#44; cross-sectional&#41; and experimental studies in humans&#44; published in any language from 1969 through September 2023&#44; which included adult patients diagnosed with severe sepsis or septic shock &#40;using a standardized definition&#41;&#44; and evaluated SI &#40;heart rate&#47;systolic blood pressure&#41; or some modified version including the MSI &#40;HR&#47;MAP&#41; &#40;MAP&#44; mean arterial pressure&#41; and the DSI &#40;HR&#47;DBP&#41; &#40;DBP&#44; diastolic blood pressure&#41;&#46; Studies published in abstract format or that could not be obtained in full text&#44; studies in COVID-19 patients&#44; and obstetric populations were excluded&#46; The protocol for this systematic review was registered in PROSPERO with No&#46; CRD42023473588&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Search structure</span><p id="par0025" class="elsevierStylePara elsevierViewall">A systematic literature search was conducted across various databases including PubMed&#44; Embase&#44; Cochrane Library&#44; and Lilacs&#46; In PubMed&#44; the search structure used was&#58; &#40;&#40;&#40;&#40;shock index&#41; OR Modified shock index&#41; OR index shock&#41; OR &#40;Diastolic shock index&#41;&#41; AND &#40;&#40;&#40;&#40;&#40;&#40;&#40;&#8220;Sepsis&#8221;&#91;Mesh&#93;&#41; OR &#8220;Sepsis&#8221;&#41; OR septic shock&#41; OR severe sepsis&#41; OR &#8220;Shock&#44; Septic&#8221;&#91;Mesh&#93;&#41; OR septic&#41; OR sepsis septic&#41; Filters&#58; Humans&#46; In the Lilacs database&#44; the structure used was&#58; &#40;&#40;tw&#58;&#40;&#40;tw&#58;&#40;choque septico&#41;&#41; OR &#40;tw&#58;&#40;sepsis&#41;&#41; OR &#40;tw&#58;&#40;septico&#41;&#41; OR &#40;tw&#58;&#40;septicemia&#41;&#41; OR &#40;tw&#58;&#40;sepsis severa&#41;&#41;&#41;&#41; AND &#40;tw&#58;&#40;&#40;tw&#58;&#40;index shock&#41;&#41; OR &#40;tw&#58;&#40;shock index&#41;&#41;&#41;&#41;&#46; A manual search of all references of articles that met the inclusion criteria was also conducted&#44; and sources of grey literature including Google Scholar&#44; OpenGrey&#44; and ClinicalTrials&#46;gov were reviewed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Article selection and data curation</span><p id="par0030" class="elsevierStylePara elsevierViewall">Initially&#44; studies were selected based on titles and abstracts&#46; Studies that initially met the eligibility criteria were read in full text to confirm these criteria&#46; This process was carried out independently by JPC&#44; FD&#44; and JT&#46; Disagreements were assessed by a third author &#40;JJDF&#41; when pertinent&#46; Rayyan software &#40;R&#41; was used for the selection process&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Data curation was performed by 2 authors &#40;JJDF and JPC&#41;&#46; Data about the study objective&#44; methods including the statistical analysis plan and sample size&#44; main results related to the shock index&#44; and conclusions of each study were obtained&#46; An Excel format was designed for this process&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Risk of bias assessment</span><p id="par0040" class="elsevierStylePara elsevierViewall">The risk of bias for each study was determined using the Joanna Briggs Institute &#40;JBI&#41; checklist forms based on each study design&#46; Two authors &#40;JJDF and JPC&#41; applied the tool to the various articles and categorized the overall risk of bias for each study using 3 levels&#58; high&#44; moderate&#44; and low risk&#46; The level of inter-rater agreement was calculated using the Kappa-Cohen test&#44; which was then categorized as null &#40;0&#46;0&#8211;0&#46;2&#41;&#44; low &#40;0&#46;2&#8211;0&#46;4&#41;&#44; moderate &#40;0&#46;4&#8211;0&#46;6&#41;&#44; good &#40;0&#46;6&#8211;0&#46;8&#41;&#44; and very good agreement &#40;0&#46;8&#8211;1&#46;0&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Effect measures</span><p id="par0045" class="elsevierStylePara elsevierViewall">To determine the effect of SI as a prognostic factor in different contexts and outcomes&#44; absolute and relative frequencies mentioned in the text were extracted&#44; as well as the respective measures of central tendency and dispersion&#46; When possible&#44; effect estimators including Odds Ratio &#40;OR&#41;&#44; Relative Risk &#40;RR&#41;&#44; and Hazard Ratio &#40;HR&#41; were extracted according to the context and methodological setting of each study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Ethical considerations</span><p id="par0050" class="elsevierStylePara elsevierViewall">The study was approved by the School of Medicine Research and Ethics Committee of the Health Sciences University Foundation&#44; under Act No&#46; 636 &#40;DI-I-0555-21&#41;&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">The search identified a total of 601 articles&#44; 67 of which were duplicates&#46; Additionally&#44; 752 articles from grey literature sources were identified&#46; After applying the selection criteria&#44; 337 manuscripts were selected for abstract review&#46; Finally&#44; 17 articles were identified for inclusion in the review &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the characteristics&#44; methodology&#44; and objectives of the included studies&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">All included studies were observational&#44; with only one being prospective&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and 8 &#40;47&#46;1&#37;&#41; being conducted in the ER&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;15&#8211;20</span></a> Sample sizes ranged from 25 to 1266 patients&#46; Twelve articles &#40;70&#46;5&#37;&#41; evaluated the SI&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;21</span></a> 4 evaluated the MSI or DSI&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;23&#44;24</span></a> and 1 study evaluated the SI&#44; MSI&#44; and DSI&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Regarding the risk of bias assessment determined using the JBI tool&#44; two reviewers conducted a paired and independent evaluation of the risk of each included study according to the epidemiological design&#46; There was a statistically significant agreement between the reviewers &#40;p &#60; 0&#46;001&#41;&#59; however&#44; the level of this agreement was low &#40;0&#46;286&#41;&#46; We found that all included articles presented a &#8220;low risk&#8221; assessment in 60&#37; or more of the content of each&#46; Concerns identified in the included studies according to their design revealed deficiencies in the identification and management of confounding factors in cross-sectional&#44; case-control&#44; and cohort studies&#46; Additionally&#44; in cohort studies&#44; further concerns were identified related to strategies employed to address incomplete follow-up in some cases&#46; The risk of bias assessment for the studies is shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Among the studies that evaluated the prognostic value of SI&#44; 4 showed statistically significant differences between the admission SI value in the survivor vs the non-survivors group&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;14&#44;15&#44;17</span></a> and one more in the evaluation of SI before the initiation of vasopressors&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Two more studies showed favorable results between the average of several SI measures in the emergency department or the variation of prehospital SI and clinical outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;21</span></a> In contrast&#44; in 4 studies&#44; prehospital SI&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a> admission SI&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> or the average SI within the first 6 hours were not associated with mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> See <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Among the 3 studies that evaluated the MSI&#44; 2 showed a favorable relationship with clinical outcomes such as myocardial depression<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> while 1 was not associated with mortality whatsoever&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Three other studies that evaluated the DSI showed a relationship with mortality<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;22</span></a> and the dose of dobutamine received&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> It is important to note that Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> conducted several statistical adjustment models to determine the association between DSI and mortality&#46; Among them&#44; only the model adjusted for age&#44; sex&#44; race&#44; and ICU management was significant&#46; However&#44; when also adjusting for SOFA scale values&#44; it was evident that DSI was not associated with mortality in hospitalized patients&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarizes the studies with prognostic evaluation of the MSI and DSI values in the septic shock population&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; two studies evaluated the response of SI to certain medical interventions&#46; Lanspa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> demonstrated that a CVP &#8805; 8 mmHg had an NPV of 83&#37; for predicting fluid response&#44; while for SI &#8804; 1&#44; it was 88&#37;&#44; and for the combination of CVP &#8805; 8 &#43; SI &#8804; 1&#44; the NPV increased to 93&#37;&#46; Al Aseri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> showed a lower SI in patients who responded to fluid management vs those who did not&#44; with a SI &#61; 1&#46;03 &#40;0&#46;3&#41; beats&#47;min&#47;mmHg vs 1&#46;28 &#40;0&#46;5&#41;&#44; respectively&#44; p &#61; 0&#46;007&#46; An SI &#8805; 0&#46;875 had a sensitivity of 81&#37; and specificity of 72&#37; to predict poor response to fluids and the need to initiate norepinephrine&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The present systematic review demonstrates that the IS has been studied in recent years in the context of patients with septic shock&#44; showing potential value in prognosis and utility for fluid management&#46; The main feature of this variable is its easy measurement&#44; allowing it to be obtained in any hospital care setting and repeated as often as necessary&#44; which is important for close monitoring and follow-up of patients with this disease&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">When analyzing the studies that evaluated the prognostic value of the variable&#44; we observed that the results were inconsistent&#46; Several aspects must be considered in this regard&#46; First&#44; the method of evaluating prognosis varied&#59; in some studies&#44; the IS was assessed as a continuous variable&#44; yielding median and mean differences&#44; while in other cases&#44; it was assessed as a categorical variable&#44; resulting in different outcomes depending on the type of analysis&#46; Second&#44; when analyzed as a categorical variable&#44; choosing the cutoff point is crucial&#46; Studies conducted on IS in patients with other pathologies use different cutoff points&#44; some to define normality and others to establish cutoffs related to prognosis&#46; Values from 0&#46;5 to 1&#46;3 beats&#47;min&#47;mmHg have been used&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;25</span></a> This wide range of values was seen in our results&#46; This aspect affects the operational performance of the IS in different evaluations&#44; making it difficult to compare studies&#46; Third&#44; some of the included studies did not show statistically significant differences in their results&#44; possibly due to the small sample size in some or the clinical heterogeneity of the patients given the complexity of each case&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13&#44;19</span></a> Specifically&#44; in the study by Jouffroy et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> an IS &#62; 1 was observed in 57&#37; of non-survivors vs 32&#37; of survivors &#40;p &#61; 0&#46;21&#41;&#46; Even though the p-value does not show statistical significance&#44; the percentage difference can be considered important from a clinical perspective&#46; Therefore&#44; &#8220;statistical significance&#8221; for exclusive reasons of p-values should not preclude the interpretation or clinical importance of a result&#46; Additionally&#44; while clinical relevance is crucial&#44; it is important to recognize that some studies&#44; after applying statistical adjustments for possible confounding variables&#44; indicate a lack of association between various iterations of the IS and in-hospital mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Consequently&#44; when interpreting the results&#44; it is recommended to exercise special caution and consider both clinical utility and the statistical tools applied&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The temporal progression of physiological variables during the resuscitation of a patient with septic shock is of high importance&#46; The so-called &#8220;lactate clearance&#8221; is the classic example&#44; in which the percentage reduction of lactate during the first hours of resuscitation is evaluated&#46; This variable has shown an important relationship with the patient&#39;s prognosis<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> and is recommended as a therapeutic goal by the latest Surviving Sepsis Campaign guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In this regard&#44; various studies have shown the importance of the temporal evolution of the IS&#46; Wira et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> demonstrated a worse prognosis in patients who maintained a sustained elevation of the IS during resuscitation at the ER&#46; Mohamed et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> showed greater importance of the IS measurement two hours after ICU admission vs the admission measurement&#44; similar to Yussof et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> who showed a higher AUC for mortality of the IS measured 2 hours after the ER admission vs the admission IS&#44; while Ospina et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> showed that the IS decreased significantly in the survivor vs to non-survivors group&#44; and Xiao et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> showed that the mean IS measured 3 hours after resuscitation was higher in non-survivors vs survivors&#44; with a higher AUC for prognosis evaluation&#46; Similarly&#44; Jouffroy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> incorporated the IS delta as an independent variable for predicting the 28-day mortality rate&#46; Interestingly&#44; the authors concluded that a negative IS delta could help physicians identify patients with severe sepsis and septic shock at a higher risk regarding the 28-day mortality rate&#46; This type of analysis suggests that this measure should be used repeatedly during initial resuscitation&#44; paying special attention to patients who do not show a decrease in the variable&#44; indicating the need for closer monitoring and adjustment in management if possible&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Regarding the clinical and hemodynamic response to IV fluid volume&#44; Monnet et al&#46; reported that in a group of 37 patients&#44; a 10&#37; increase in stroke volume or a 15&#37; increase in pulse pressure were highlighted as simple and significant clinical indicators for predicting fluid responsiveness in critically ill patients during passive leg raising&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The IS was also investigated during fluid administration maneuvers&#46; Mohamed et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> provided data showing a decrease in IS measured 15 minutes after fluid administration in both survivors and non-survivors&#44; without observing significant differences between both groups&#46; Lanspa et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> conducted an interesting study showing how the combined measurement of CVP with IS identifies those labeled as &#8220;non-responders to fluids&#8221;&#44; patients who do not increase cardiac output by more than 15&#37; after a fluid challenge in a short time &#40;fluid challenge&#41;&#46; This is important&#44; considering that identifying this &#8220;response&#8221; is seen as fundamental to managing these patients and is part of the recommendations of the current Surviving Sepsis Campaign guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which require the use of special monitoring that is not always available in all patient care units&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a> Al Aseri et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> evaluated the IS to estimate a cutoff point that identifies the patient with hemodynamic collapse who will require vasopressors&#44; with an IS &#62; 0&#46;87 identifying the patient who will not respond to fluids&#44; meaning they will require vasopressors&#44; with greater specificity and sensitivity&#46; Similarly&#44; according to Razazi et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> the IS could function as a clinical marker of response to dobutamine resuscitation in patients with septic cardiomyopathy&#44; regardless of the dose used&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In 3 studies&#44; the DSI was evaluated&#44; an index presented not only as a variable contributing to patient prognosis but also as one with potential utility in patient management as it can identify patients requiring early vasopressor intervention&#44; an important concept today&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> The proposal is based on the fact that the loss of arterial elastance is a key element in the pathophysiology of circulatory compromise in septic shock&#46; This condition leads to a decrease in DBP and&#44; therefore&#44; a compromised DSI&#46; Ospina et al&#46; identified that the risk of higher mortality was more clearly identified with DSI rather than IS or DBP&#44; suggesting that this index could be used as a variable to define interventions in the management of these patients&#46; These hypotheses on the potential clinical use of IS and DSI in management algorithms should be evaluated in studies designed for this purpose&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The limitations of IS are notable due to its static nature&#44; which makes it difficult to objectively evaluate the clinical and hemodynamic progression of patients from their admission and during treatment&#46; Additionally&#44; IS is problematic for assessing the effect of volume administration on cardiac output&#44; as other clinical variables can modify blood pressure readings&#44; indirectly affecting the IS value&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">33&#8211;35</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Moreover&#44; it is important to note that fluid responsiveness does not guarantee better oxygen consumption&#46; It is estimated that only about half &#40;56&#37;&#41; of patients who respond to fluids experience an increase in their oxygen consumption&#46; Therefore&#44; even if there are increases in blood pressure or even cardiac output&#44; this does not necessarily guarantee an increase in tissue perfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> For this reason&#44; it is suggested that IS should be integrated into fluid resuscitation protocols in septic patients&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">IS has been frequently studied in patients with septic shock&#59; few studies have been identified with other versions of IS&#46; The results suggest that both IS and its modified versions in single and serial evaluations can be considered for evaluating patient prognosis&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Our study presents several limitations&#46; First&#44; all studies&#44; except for one&#44; are retrospective&#44; which is associated with certain biases inherent to these designs&#44; mainly confounding bias&#46; Second&#44; there is notable clinical heterogeneity in the presentation and measurement of the variables of interest&#44; including variability in the timing of measurement during the length of stay and the different contexts and places where the variables are determined&#44; such as emergency services&#44; hospitalization wards&#44; and intensive care units&#46; Additionally&#44; there are other potentially confounding factors&#44; such as comorbidities&#44; the patients&#8217; baseline clinical status&#44; and the use of pharmacological therapies&#46; Third&#44; the lack of consistency in study selection criteria limits the generalization of the results to the entire population&#46; Due to the above-mentioned limitations&#44; it is not appropriate to perform a meta-analysis of the results&#44; which prevents providing a weighted effect estimator&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Authors&#8217; contributions</span><p id="par0145" class="elsevierStylePara elsevierViewall">Conceptualization&#58; JJDF&#44; JPCG&#44; MASO&#46; Data mining and management&#58; JJDF&#44; JPCG&#44; MASO&#44; JITZ&#44; FEDM&#46; Data analysis&#58; JJDF&#44; JPCG&#46; Project administration&#58; JJDF&#46; Manuscript writing &#40;original draft&#41;&#58; JJDF&#44; JPCG&#46; Manuscript review and editing&#58; JJDF&#44; JPCG&#44; MASO&#44; JITZ&#44; FEDM&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
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    "fechaRecibido" => "2023-12-27"
    "fechaAceptado" => "2024-06-23"
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            0 => "Sepsis"
            1 => "Choque s&#233;ptico"
            2 => "Lactato"
            3 => "&#205;ndice de shock"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To identify published research on the Shock Index &#40;SI&#41; in patients with septic shock or severe sepsis and to describe its main findings and conclusions&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Systematic review of the literature following the recommendations of the PRISMA protocol &#40;Preferred Reporting Items for Systematic Reviews and Meta-Analyses&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Settings</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The following databases were consulted&#58; Pubmed&#44; Embase&#44; Library Cochrane and Lilacs&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Patients</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patients older than 14 years with septic shock&#46; Pregnant women and population with COVID-19 were excluded&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Interventions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Studies reporting measurement of the shock index or its modified variants&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Main variables of interest</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Absolute frequencies and relative frequencies were assessed with measures of central tendency and dispersion&#46; Effect estimators &#40;OR&#44; RR and HR&#41; were extracted according to the context of each study&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Seventeen articles were included&#44; of which 11 investigated the SI as a predictor of mortality&#46; Seven of them found significant differences in the SI when comparing survivors to non-survivors and observed a relationship between the SI evolution and clinical outcomes&#46; Additional research evidenced a relation between the Modified Shock Index and myocardial depression&#44; as well as mortality&#46; Furthermore&#44; they identified a relationship between the Diastolic Shock Index&#44; the dose of administered dobutamine&#44; and mortality&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">The results suggest that both the SI and its modified versions&#44; particularly in serial assessments&#44; can be considered for evaluating patient prognosis&#46; The SI can also aid in determining fluid management for patients&#46;</p></span>"
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        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objetivo</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Identificar las investigaciones publicadas sobre el &#205;ndice de Shock &#40;IS&#41; en pacientes con choque s&#233;ptico o sepsis severa y describir sus principales resultados y conclusiones&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Dise&#241;o</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n sistem&#225;tica de la literatura siguiendo las recomendaciones del protocolo PRISMA &#40;Preferred Reporting Items for Systematic Reviews and Meta-Analyses&#41;&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">&#193;mbito</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Se consultaron las bases de datos&#58; Pubmed&#44; Embase&#44; Library Cochrane y Lilacs&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Pacientes mayores de 14 a&#241;os con choque s&#233;ptico&#46; Se excluyeron mujeres embarazadas y poblaci&#243;n con COVID-19&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Intervenciones</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Estudios que reportaran la medici&#243;n del &#237;ndice de choque o sus variantes modificadas&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables de inter&#233;s principales</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Se evaluaron frecuencias absolutas y frecuencias relativas con medidas de tendencia central y dispersi&#243;n&#46; Se extrajeron estimadores de efecto &#40;OR&#44; RR y HR&#41; seg&#250;n el contexto de cada estudio&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 17 art&#237;culos&#44; de los cuales 11 investigaron el IS como un predictor de mortalidad&#46; 7 encontraron diferencias significativas en el IS al comparar supervivientes de no supervivientes&#44; y observaron una relaci&#243;n entre la evoluci&#243;n del IS y los resultados cl&#237;nicos&#46; Investigaciones adicionales evidenciaron una relaci&#243;n entre el &#205;ndice de Shock Modificado y la depresi&#243;n mioc&#225;rdica&#44; as&#237; como con la mortalidad&#46; Adem&#225;s&#44; identificaron una relaci&#243;n entre el &#205;ndice de Shock Diast&#243;lico&#44; la dosis de dobutamina administrada y la mortalidad&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Los resultados sugieren que tanto el IS como sus versiones modificadas&#44; principalmente en evaluaciones seriadas&#44; pueden ser tenidos en cuenta para evaluar el pron&#243;stico del paciente&#46; El IS tambi&#233;n puede ser &#250;til en definir el uso de l&#237;quidos en los pacientes&#46;</p></span>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">SI&#58; shock index&#59; ICU&#58; intensive care unit&#59; MSI&#58; modified shock index&#59; DSI&#58; diastolic shock index&#59; SIGARC&#58; shock index &#8805; 1&#59; Glasgow coma scale &#60; 13&#59; age &#62; 65&#59; respiratory rate &#62; 22&#59; Comorbidity&#59; PSPoT&#58; prehospital shock precautions on triage&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Author and year of publication&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lanspa MJ&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICU of shock&#47;trauma and respiratory&#46;N &#61; 25Prospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the combination of SI and central venous pressure among fluid responders and non-responders&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yussof S&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 50Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Determine the prognostic value of SI measured upon arrival at the ER and 2 hours after IV fluid resuscitation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wira C&#46; et al&#46; &#40;2014&#41;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 295Cross-sectional&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate sustained elevation of SI as a predictor of short-term cardiovascular collapse&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mohamed A&#46; et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical ICUN &#61; 58Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate changes in SI&#44; vascular permeability index&#44; and lactate&#47;pyruvate ratio in response to fluid challenge&#44; and their relation to ICU survival and non-invasive monitoring predictability&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jayaprakash N&#46; et al&#46; &#40;2017&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 578Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Explore the association of elevated MSI and myocardial dysfunction&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wu A&#46; et al&#46; &#40;2018&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 127Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the correlation between SI and severity and prognostic values&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 114Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between SI and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ospina-Tasc&#243;n G&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 761Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate MSI and clinical outcomes&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Al Aseri Z&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emergency Department N &#61; 98 Cross-sectional&#44; Single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the utility of SI as a predictive tool for poor response to IV fluid management&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xiao J&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 154Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observe the correlation among SI&#44; pulmonary vascular permeability index&#44; and clinical severity&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 406Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between SI&#44; prehospital SIGARC score&#44; and in-hospital mortality at 30 and 90 days&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 181Prospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Describe the association between the prehospital PSPoT score and hospital mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lee S&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ERN &#61; 340Retrospective&#44; single-center&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Observe the association between time-weighted mean hemodynamic parameters during initial resuscitation and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prehospital mobile ICUN &#61; 406Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the association between prehospital SI variation and 28-day mortality&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 1266Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the relationship between SI&#44; MSI&#44; and DSI with 3-day mortality and initiation of vasopressors&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#225;nchez-D&#237;az JS&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 60Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Evaluate the association between MSI and in-hospital mortality in patients with sepsis of abdominal origin&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Razazi K&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical-surgical ICUN &#61; 32Retrospective&#44; multicenter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Characterize the hemodynamic response&#44; including DSI in patients with septic cardiomyopathy on dobutamine&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">SI&#58; shock index&#59; AUC&#58; area under the ROC Curve&#59; OR&#58; odds ratio&#59; PPV&#58; positive predictive value&#59; NPV&#58; negative predictive value&#59; HR&#58; hazard ratio&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lead author&#44; year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Main Results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yussof S&#46; et al&#46; &#40;2012&#41;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- SI at admission and in-hospital mortality&#58;Survivors &#61; 1&#46;2Deceased &#61; 1&#46;4&#44; p &#61; 0&#46;009<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1 two hours post-admission&#58;</span></span>Sensitivity &#61; 80&#46;8&#37;&#44; Specificity &#61; 79&#46;2&#37;&#44; AUC &#61; 0&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wira C&#46; et al&#46; &#40;2014&#41;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Sustained SI elevation &#62; 0&#46;8 during more than 80&#37; of vital sign measurements at the ER and clinical outcomes</span></span>&#58;Higher vasopressor requirement &#40;OR&#44; 4&#46;42&#44; 95&#37; CI&#44; 2&#46;28&#8211;8&#46;55&#41; and a greater number of total organ failures cs the group without such sustained elevation &#40;4&#46;0 &#177; 2&#46;1 vs 3&#46;2 &#177; 1&#46;6&#44; p &#61; 0&#46;0001&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mohamed A&#46; et al&#46; &#40;2016&#41;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and hospital mortality&#58;</span></span>Survivors &#61; 0&#46;89Deceased &#61; 1&#46;05&#44; p &#62; 0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wu A&#46; et al&#46; &#40;2018&#41;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;35 &#177; 0&#46;32Deceased &#61; 1&#46;62 &#177; 0&#46;46 &#40;p &#60; 0&#46;01&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI 3 hours post-admssion and 28-day mortality&#58;</span></span>Survivors &#61; 0&#46;93 &#177; 0&#46;15Deceased &#61; 1&#46;36 &#177; 0&#46;24 &#40;p &#60; 0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and in-hospital mortality&#58;</span></span>Survivors &#61; 0&#46;73 &#40;0&#46;61&#8211;1&#46;00&#41;Deceased &#61; 0&#46;80 &#40;0&#46;66&#8211;1&#46;10&#41;&#44; p &#60; 0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Xiao J&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI at admssion and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;36 &#177; 0&#46;31Deceased &#61; 1&#46;63 &#177; 0&#46;29 &#40;p &#60; 0&#46;001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1&#46;72&#58;</span></span>Sensitivity &#61; 91&#46;2&#37;&#44; Specificity &#61; 89&#46;4&#37;&#44; PPV &#61; 0&#46;91&#44; NPV &#61; 0&#46;92<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI 3 hours post-admission&#58;</span></span>Survivors &#61; 0&#46;92 &#177; 0&#46;14Deceased &#61; 1&#46;37 &#177; 0&#46;13 &#40;p &#60; 0&#46;001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI &#8805; 1&#46;22&#58;</span></span>Sensitivity &#61; 90&#46;1&#37;&#44; Specificity &#61; 85&#46;7&#37;&#44; PPV &#61; 0&#46;89&#44; NPV &#61; 0&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI and in-hospital mortality&#58;</span></span>Survivors &#61; 1&#46;1 &#177; 0&#46;5Deceased &#61; 1&#46;1 &#177; 0&#46;5&#44; p &#61; 0&#46;706&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI &#62; 1 and in-hospital mortality&#58;</span></span>Survivors&#44; n &#61; 38 &#40;32&#37;&#41;Deceased&#44; n &#61; 28 &#40;28&#37;&#41;&#44; p &#61; 0&#46;213&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lee S&#46; et al&#46; &#40;2021&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Mean SI within the first 6 hours and 28-day mortality&#58;</span></span>Survivors &#61; 1&#46;06Deceased &#61; 1&#46;06&#44; p &#61; 0&#46;244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jouffroy R&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- Prehospital SI delta and 28-day mortality&#58;</span></span>Negative delta HR&#44; 1&#46;88 &#40;95&#37; CI&#44; 1&#46;07&#8211;3&#46;31&#41; &#40;p &#61; 0&#46;03&#41;Positive delta HR&#44; 0&#46;53 &#40;95&#37; CI&#44; 0&#46;30&#8211;0&#46;94&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- SI before the start of vasopressors and 3-day mortality&#58;</span></span>Average SI &#61; 1&#46;32 vs 0&#46;64 OR&#44; 6&#46;43 &#40;95&#37; CI&#44; 3&#46;26&#8211;14&#46;22&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Prognostic evaluation of SI value in septic shock population&#46;</p>"
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      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SI&#59; shock index&#58; MSI&#59; modified shock index&#58; DSI&#59; diastolic shock index&#58; AUC&#59; area under the ROC Curve&#58; OR&#59; odds ratio&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lead author&#44; year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Main results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Jayaprakash N&#46; et al&#46; &#40;2017&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI with dysfunction and myocardial depression&#58;</span></span>AUC of various measurements within the first 6 hours and myocardial depression&#58; OR&#44; 1&#46;28&#44; 95&#37; CI&#44; 1&#46;07&#8211;1&#46;53&#44; p &#61; 0&#46;007&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ospina-Tasc&#243;n G&#46; et al&#46; &#40;2020&#41;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI before the start of vasopressors and 90-day mortality&#58;</span></span>RR increased between quintile 1 &#40;Q1&#41; and quintile 5 &#40;Q5&#41; &#40;p &#60; 0&#46;001&#41;Decrease wihtin the first 8 hours of resuscitation among survivors vs non-survivors&#44; p &#60; 0&#46;001&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zhang TN&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI before the start of vasopressors and 3-day mortality&#58;</span></span>Range&#44; fourth quartile IS &#61; 1&#46;64&#8211;5&#46;78 vs Range&#44; first quartile IS &#61; 0&#46;44&#8211;1&#46;12OR&#44; 3&#46;78 &#40;95&#37; CI&#44; 2&#46;05&#8211;7&#46;45&#41; &#40;p &#60; 0&#46;0001&#41;<span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI before the start of vasopressors and 3-day mortality&#58;</span></span>Range&#44; fourth quartile IS &#61; 1&#46;96&#8211;11&#46;9 vs Range&#44; first quartile IS &#61; 0&#46;46&#8211;1&#46;35OR&#44; 4 &#40;95&#37; CI&#44; 2&#46;18&#8211;7&#46;86&#41; &#40;p &#60; 0&#46;0001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#225;nchez-D&#237;az JS&#46; et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- MSI at admission &#62; 1&#46;3 and in-hospital mortality&#58;</span></span>Survivors&#44; n &#61; 26 &#40;83&#46;9&#37;&#41;Deceased&#44; n &#61; 24 &#40;82&#46;8&#37;&#41;&#44; p &#61; 0&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Razazi et al&#46; &#40;2022&#41;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">- DSI and dobutamine dose&#58;</span></span>0 mcg&#47;kg&#47;min&#44; DSI &#61; 1&#46;7 &#40;1&#46;4&#8211;1&#46;0&#41;&#8805; 5 mcg&#47;kg&#47;min&#44;DSI &#61; 2&#46;1 &#40;1&#46;7&#8211;2&#46;7&#41; &#40;p &#60; 0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Prognostic evaluation of MSI and DSI values in septic shock population&#46;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:36 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shock index&#58; a re-evaluation in acute circulatory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;Y&#46; Rady"
                            1 => "P&#46; Nightingale"
                            2 => "R&#46;A&#46; Little"
                            3 => "J&#46;D&#46; Edwards"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0300-9572(92)90006-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Resuscitation"
                        "fecha" => "1992"
                        "volumen" => "23"
                        "paginaInicial" => "227"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1321482"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shock index as a predictor for mortality in trauma patients&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Vang"
                            1 => "M&#46; &#216;stberg"
                            2 => "J&#46; Steinmetz"
                            3 => "L&#46;S&#46; Rasmussen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00068-022-01932-z"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Trauma Emerg Surg"
                        "fecha" => "2022"
                        "volumen" => "48"
                        "paginaInicial" => "2559"
                        "paginaFinal" => "2566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35258641"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0015"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Shock index predicts outcome in patients with suspected sepsis or community-acquired pneumonia&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Smith Middleton"
                            1 => "Neilly Bedford"
                            2 => "Myint"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/jcm8081144"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Med"
                        "fecha" => "2019"
                        "volumen" => "8"
                        "paginaInicial" => "1144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31370356"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Utilizaci&#243;n del &#237;ndice de shock en el manejo de pacientes con sepsis severa y choque s&#233;ptico&#58; una revisi&#243;n sistem&#225;tica"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;J&#46; Diaztagle Fern&#225;ndez"
                            1 => "W&#46;A&#46; G&#243;mez N&#250;&#241;ez"
                            2 => "M&#46; Plazas Vargas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Colomb Cuid Intensivo"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "262"
                        "paginaFinal" => "269"
                      ]
                    ]
                  ]
                ]
              ]
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            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elevated modified shock index in early sepsis is associated with myocardial dysfunction and mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Jayaprakash"
                            1 => "O&#46; Gajic"
                            2 => "R&#46;D&#46; Frank"
                            3 => "N&#46; Smischney"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jcrc.2017.08.019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2018"
                        "volumen" => "43"
                        "paginaInicial" => "30"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28843067"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic shock index and clinical outcomes in patients with septic shock"
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                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Ospina-Tasc&#243;n"
                            1 => "J&#46;L&#46; Teboul"
                            2 => "G&#46; Hernandez"
                            3 => "I&#46; Alvarez"
                            4 => "A&#46;I&#46; S&#225;nchez-Ortiz"
                            5 => "L&#46;E&#46; Calder&#243;n-Tapia"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13613-020-00658-8"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Intensive Care"
                        "fecha" => "2020"
                        "volumen" => "10"
                        "paginaInicial" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32296976"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0035"
              "etiqueta" => "7"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Surviving sepsis campaign&#58; international guidelines for management of sepsis and septic shock 2021"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46; Rhodes"
                            2 => "W&#46; Alhazzani"
                            3 => "M&#46; Antonelli"
                            4 => "C&#46;M&#46; Coopersmith"
                            5 => "C&#46; French"
                          ]
                        ]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1007/s00134-021-06506-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2021"
                        "volumen" => "47"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34599691"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rayyan&#8212;a web and mobile app for systematic reviews"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ouzzani"
                            1 => "H&#46; Hammady"
                            2 => "Z&#46; Fedorowicz"
                            3 => "A&#46; Elmagarmid"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13643-016-0384-4"
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                        "tituloSerie" => "Syst Rev"
                        "fecha" => "2016"
                        "volumen" => "5"
                        "paginaInicial" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27919275"
                            "web" => "Medline"
                          ]
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            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "JBI&#8217;s systematic reviews"
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                          "autores" => array:3 [
                            0 => "Z&#46; Munn"
                            1 => "C&#46; Tufanaru"
                            2 => "E&#46; Aromataris"
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "AJN&#44; Am J Nurs"
                        "fecha" => "2014"
                        "volumen" => "114"
                        "paginaInicial" => "49"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25742352"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Central venous pressure and shock index predict lack of hemodynamic response to volume expansion in septic shock&#58; a prospective&#44; observational study"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "S&#46;M&#46; Brown"
                            2 => "E&#46;L&#46; Hirshberg"
                            3 => "J&#46;P&#46; Jones"
                            4 => "C&#46;K&#46; Grissom"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "609"
                        "paginaFinal" => "615"
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0055"
              "etiqueta" => "11"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Value of Shock Index in prognosticating the short-term outcome of death for patients presenting with severe sepsis and septic shock in the emergency department"
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                          "etal" => false
                          "autores" => array:6 [
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                            2 => "F&#46;L&#46; Mohamed"
                            3 => "M&#46;A&#46; Bujang"
                            4 => "S&#46; Lakshmanan"
                            5 => "A&#46;H&#46; Asaari"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med J Malaysia"
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                        "volumen" => "67"
                        "paginaInicial" => "406"
                        "paginaFinal" => "411"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23082451"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The shock index as a predictor of vasopressor use in emergency department patients with severe sepsis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;R&#46; Wira"
                            1 => "M&#46;W&#46; Francis"
                            2 => "S&#46; Bhat"
                            3 => "R&#46; Ehrman"
                            4 => "D&#46; Conner"
                            5 => "M&#46; Siegel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5811/westjem.2013.7.18472"
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                        "tituloSerie" => "West J Emerg Med"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "60"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24696751"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0065"
              "etiqueta" => "13"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Disturbed fluid responsiveness and lactate&#47;pyruvate ratio as predictors for mortality of septic shock patients"
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                          "etal" => false
                          "autores" => array:2 [
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Egypt J Anaesth"
                        "fecha" => "2016"
                        "volumen" => "32"
                        "paginaInicial" => "451"
                        "paginaFinal" => "461"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Correlation between shock index and severity of septic shock and its prognostic value"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            3 => "Y&#46; Ni"
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                        "tituloSerie" => "Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"
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                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prehospital shock index to assess 28-day mortality for septic shock"
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                        "tituloSerie" => "Am J Emerg Med"
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                      "titulo" => "The use of the shock index to predict hemodynamic collapse in hypotensive sepsis patients&#58; a cross-sectional analysis"
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                        "tituloSerie" => "Saudi J Anaesth"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32317874"
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                        "paginaInicial" => "1"
                        "paginaFinal" => "8"
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                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
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                        "paginaInicial" => "355"
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                        "link" => array:1 [
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              "identificador" => "bib0095"
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                0 => array:2 [
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                      "titulo" => "Prehospital Shock Precautions on Triage &#40;PSPoT&#41; score to assess in-hospital mortality for septic shock"
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                        "link" => array:1 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy"
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                        "tituloSerie" => "Korean J Intern Med"
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                        "volumen" => "36"
                        "paginaInicial" => "924"
                        "paginaFinal" => "931"
                      ]
                    ]
                  ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Association between prehospital shock index variation and 28-day mortality among patients with septic shock"
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                          "autores" => array:6 [
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                            1 => "B&#46; Gilbert"
                            2 => "L&#46; Thomas"
                            3 => "E&#46; Bloch-Laine"
                            4 => "P&#46; Ecollan"
                            5 => "J&#46; Boularan"
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                      ]
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                  ]
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                    0 => array:2 [
                      "doi" => "10.1186/s12873-022-00645-1"
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                        "fecha" => "2022"
                        "volumen" => "22"
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                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of SI&#44; MSI and DSI for very early &#40;3-day&#41; mortality in patients with septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;N&#46; Zhang"
                            1 => "P&#46;H&#46; Hao"
                            2 => "S&#46;Y&#46; Gao"
                            3 => "C&#46;F&#46; Liu"
                            4 => "N&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s40001-022-00857-y"
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Med Res"
                        "fecha" => "2022"
                        "volumen" => "27"
                        "paginaInicial" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36329534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simplified acute physiology score II and Mannheim peritonitis index are associated with in-hospital mortality in patients with abdominal sepsis admitted to ICU"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; S&#225;nchez-D&#237;az"
                            1 => "D&#46; Escarraman-Mart&#237;nez"
                            2 => "M&#46;A&#46; Guerrero-Guti&#233;rrez"
                            3 => "H&#46;D&#46; Meza-Compar&#225;n"
                            4 => "J&#46; Mancilla-Galindo"
                            5 => "K&#46;G&#46; Peniche-Moguel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cir Cir"
                        "fecha" => "2022"
                        "volumen" => "90"
                        "itemHostRev" => array:3 [
                          "pii" => "S009167492030573X"
                          "estado" => "S300"
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                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic effects and tolerance of dobutamine for myocardial dysfunction during septic shock&#58; An observational multicenter prospective echocardiographic study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Razazi"
                            1 => "V&#46; Labb&#233;"
                            2 => "L&#46; Laine"
                            3 => "A&#46; Bedet"
                            4 => "G&#46; Carteaux"
                            5 => "N&#46; de Prost"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Front Cardiovasc Med"
                        "fecha" => "2022"
                        "volumen" => "9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Review article&#58; Shock Index for prediction of critical bleeding post&#8208;trauma&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Olaussen"
                            1 => "T&#46; Blackburn"
                            2 => "B&#46; Mitra"
                            3 => "M&#46; Fitzgerald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1742-6723.12232"
                      "Revista" => array:6 [
                        "tituloSerie" => "Emerg Med Australas"
                        "fecha" => "2014"
                        "volumen" => "26"
                        "paginaInicial" => "223"
                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24712642"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood lactate levels in sepsis&#58; in 8 questions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;L&#46; Vincent"
                            1 => "J&#46; Bakker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCC.0000000000000824"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Crit Care"
                        "fecha" => "2021"
                        "volumen" => "27"
                        "paginaInicial" => "298"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33852499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Porcentajes de cambio del lactato en pacientes con choque s&#233;ptico tard&#237;o&#46; Un an&#225;lisis de pacientes individuales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Diaztagle Fern&#225;ndez"
                            1 => "J&#46;D&#46; Caicedo Ruiz"
                            2 => "A&#46;F&#46; Hern&#225;ndez Segura"
                            3 => "J&#46;I&#46; Alvarado S&#225;nchez"
                            4 => "J&#46;A&#46; Navarrete Ria&#241;o"
                            5 => "L&#46;E&#46; Cruz Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Colomb Cuid Intensivo"
                        "fecha" => "2021"
                        "volumen" => "21"
                        "paginaInicial" => "33"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Passive leg raising predicts fluid responsiveness in the critically ill&#42;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Monnet"
                            1 => "M&#46; Rienzo"
                            2 => "D&#46; Osman"
                            3 => "N&#46; Anguel"
                            4 => "C&#46; Richard"
                            5 => "M&#46;R&#46; Pinsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.CCM.0000215453.11735.06"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "34"
                        "paginaInicial" => "1402"
                        "paginaFinal" => "1407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16540963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of fluid responsiveness&#46; What&#8217;s new&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Monnet"
                            1 => "R&#46; Shi"
                            2 => "J&#46;L&#46; Teboul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13613-022-01022-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intensive Care"
                        "fecha" => "2022"
                        "volumen" => "12"
                        "paginaInicial" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35633423"
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              "identificador" => "bib0150"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The prediction of fluid responsiveness"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2023"
                        "volumen" => "49"
                        "paginaInicial" => "83"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36323911"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of very early start of norepinephrine in patients with septic shock&#58; a propensity score-based analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "G&#46; Hernandez"
                            2 => "I&#46; Alvarez"
                            3 => "L&#46;E&#46; Calder&#243;n-Tapia"
                            4 => "R&#46; Manzano-Nunez"
                            5 => "A&#46;I&#46; S&#225;nchez-Ortiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13054-020-2756-3"
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2020"
                        "volumen" => "24"
                        "paginaInicial" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32059682"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How I personalize fluid therapy in septic shock&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Monnet"
                            1 => "C&#46; Lai"
                            2 => "J&#46;L&#46; Teboul"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Crit Care"
                        "fecha" => "2023"
                        "volumen" => "27"
                        "paginaInicial" => "123"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluaci&#243;n de la contractilidad y la poscarga en la unidad de cuidados intensivos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Ochagav&#237;a"
                            1 => "L&#46; Zapata"
                            2 => "A&#46; Carrillo"
                            3 => "A&#46; Rodr&#237;guez"
                            4 => "M&#46; Guerrero"
                            5 => "J&#46;M&#46; Ayuela"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2012.02.010"
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                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2012"
                        "volumen" => "36"
                        "paginaInicial" => "365"
                        "paginaFinal" => "374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22482957"
                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge in patients with septic shock&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Pierrakos"
                            1 => "D&#46; Velissaris"
                            2 => "S&#46; Scolletta"
                            3 => "S&#46; Heenen"
                            4 => "D&#46; De Backer"
                            5 => "J&#46;-L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-011-2457-0"
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                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2012"
                        "volumen" => "38"
                        "paginaInicial" => "422"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22278593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactate and venoarterial carbon dioxide difference&#47;arterial-venous oxygen difference ratio&#44; but not central venous oxygen saturation&#44; predict increase in oxygen consumption in fluid responders&#42;"
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                        0 => array:2 [
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                            4 => "C&#46; Gosset"
                            5 => "M&#46; Jozwiak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e318275cece"
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                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "41"
                        "paginaInicial" => "1412"
                        "paginaFinal" => "1420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23442986"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Assessment of volume responsiveness during mechanical ventilation&#58; Recent advances"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "X&#46; Monnet"
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                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:4 [
                        "tituloSerie" => "Crit Care"
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                      ]
                    ]
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Original language: English
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