Publish in this journal
Journal Information
Vol. 44. Issue 8.
Pages 485-492 (November 2020)
Share
Share
Download PDF
More article options
ePub
Visits
...
Vol. 44. Issue 8.
Pages 485-492 (November 2020)
Original
DOI: 10.1016/j.medine.2020.08.002
Mortality study in patients at weaning from mechanical ventilation
Estudio de mortalidad de pacientes en desconexión progresiva del ventilador
Visits
...
J.A. Santos Rodriguez
Corresponding author
jsantosr@santpau.cat

Corresponding author.
, J. Mancebo Cortés
Servicio de Medicina Intensiva. Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (5)
Show moreShow less
Tables (6)
Table 1. Patient’s characteristics and progression.
Table 2. Relevant variables between alive and death patients.
Table 3a. Logistics regression without adjustments in the IMS setting, odds ratio of WIND groups 3 vs. 1: 11.3; 95%CI (3.7-34.7); P < .001. Logistics regression adjusted in the IMS setting.
Table 3b. Cox proportional hazards regression model without adjustments in the IMS setting, hazard ratio of WIND groups 3 vs. 1: 1.2; 95%CI (0.4-3.6); P = .728. Cox proportional hazards regression model adjusted in the IMS setting.
Table 4a. Logistics regression without adjustments in the hospital setting. Odds ratio of groups WIND 3 vs. 1: 4.0; 95%CI 1.5-10.8; P = .007. Logistics regression adjusted in the hospital setting.
Table 4b. Cox proportional hazards regression model without adjustments in the hospital setting, hazard ratio of WIND groups 3 vs. 1: 1.6; 95%CI 0.7-3.4; P = .233. Cox proportional hazards regression model adjusted in the hospital setting.
Show moreShow less
Abstract
Objective

To explain mortality in the ICU and in hospital among patients subjected to invasive mechanical ventilation.

Design

A prospective, 9-month observational cohort study was carried out.

Setting

A Department of Intensive Care Medicine.

Patients

Consecutive patients requiring invasive mechanical ventilation were followed-up on until hospital discharge or death.

Interventions

None.

Interest variables

Date of admission, day of first spontaneous breathing test, length of mechanical ventilation, final extubation date, days in ICU, days in hospital or discharge from ICU, SAPS 3 score, WIND study classification, day of death, hospital discharge.

Measurements and main results

There were 266 patients: 40 in group 0 of the WIND classification, 15% 95%CI (11-20%); 166 in group 1, 62% 95%CI (56-68%); 38 in group 2, 14% 95%CI (11-19%); and 22 in group 3, 8% 95%CI (6-12%). Logistic regression analysis showed group 3 to have the highest hospital mortality (group 3 vs group 1; OR 4.0 95%CI (1.5–10.8)). However, Cox regression analysis showed no significant differences (HR group 3 vs group 1, 1.6 95%CI (0.7–3.4), p = ns).

Conclusions

In our study, considering exposure time, the probability of mortality was the same among the three different groups of patients with at least one spontaneous breathing test.

Keywords:
Outcomes
Weaning from mechanical ventilation
Logistic regression
Cox regression
Resumen
Objetivo

Explicar mortalidad de pacientes con ventilación mecánica invasiva en el Servicio de Medicina Intensiva (SMI) y en el hospital.

Diseño

Prospectivo de cohortes. Duración: 9 meses.

Ámbito

Servicio de Medicina Intensiva.

Pacientes

En ventilación mecánica en el Servicio de Medicina Intensiva, desde la intubación hasta el alta del hospital.

Intervenciones

Ninguna.

Variables de interés

Fecha de ingreso, día de primera prueba de desconexión de la ventilación, días de ventilación mecánica, día de extubación final, los días de estancia en SMI y en el hospital, día de muerte o traslado del SMI, SAPS 3, clasificación del estudio WIND, día de muerte o alta de hospital.

Resultados

De 266 pacientes, 40 eran del grupo 0 de la clasificación WIND, 15% IC 95%, (11-20%); 166 del grupo 1, 62% IC 95%, (56-68%); 38 del grupo 2, 14% IC 95%, (11-19%); y 22 del grupo 3, 8% IC 95%, (6-12%). Usando regresión logística, el grupo 3 tiene la más alta probabilidad de muerte en el hospital: grupo 3 vs 1, “odds ratio” 4,0 IC95% (1,5-10,8) p = 0,007). Sin embargo, no se observaron diferencias en la mortalidad del grupo 3 vs 1 empleando el método de regresión de Cox (“hazard ratio” 1,6 IC95% (0,7−3,4), p = ns).

Conclusión

En nuestro estudio, y teniendo en cuenta el tiempo de exposición, la mortalidad es la misma entre los tres diferentes grupos de pacientes que se han sometido a una prueba de desconexión de la ventilación.

Palabras clave:
Desenlaces
Desconexión de la ventilación mecánica
Regresión logística
Regresión de Cox

Article

These are the options to access the full texts of the publication Medicina Intensiva (English Edition)
Member
If you are a member of the Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias::
Go to the members area of the website of the SEMICYUC (www.semicyuc.org )and click the link to the magazine.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Intensiva (English Edition)

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Medicina Intensiva (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.