Journal Information
Vol. 47. Issue 10.
Pages 565-574 (October 2023)
Share
Share
Download PDF
More article options
ePub
Visits
74
Vol. 47. Issue 10.
Pages 565-574 (October 2023)
Original article
Obesity and the obesity paradox in patients with severe COVID-19
Obesidad y paradoja de la obesidad en pacientes con COVID-19 severo: Resultados de dos cohortes prospectivas
Visits
74
John Jaime Sprockel Díaza,b,c,
Corresponding author
jjsprockel@fucsalud.edu.co

Corresponding author.
, Victoria Eugenia Coral Zuñigab, Eliana Angarita Gonzalezb, Sebastián Camilo Tabares Rodríguezb, María Paula Carrillo Ayerbeb, Iván Santiago Acuña Cortesb, Ruddy Paola Montoya Rumpfb, Luis Oswaldo Martínez Ariasa,b, Jhon Edisson Parrac, Juan José Diaztagle Fernándeza,b,d
a Internal Medicine Department, Hospital San Jose (San Jose Hospital), Bogota, Colombia
b Fundacion Universitaria De Ciencias De La Salud (University Foundation of Health Sciences), Bogota, Colombia
c Intensive Care Unit of El Tunal Hospital — Comprehensive Health Services Southern Sub-network (Unidad de Cuidados Intensivos del Hospital El Tunal – Subred Integrada de Servicios de Salud del Sur), Bogota, Colombia
d Department of Physiological Sciences, School of Medicine, National University of Colombia – Bogota, Bogota, Colombia
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (3)
Table 1. General characteristics of the population hospitalized in general and intensive care wards classified on the basis of the presence or absence of obesity.
Table 2. Classification of weight grading and bivariate analysis with respect to admission to intensive care (done on 359 inpatients with BMI data) and to death (done on 251 intensive care patients with BMI data).
Table 3. Results of bi- and multivariate Cox analyses regarding the association of various risk factors with admission of patients hospitalized in the general ward for COVID-19 to intensive care.
Show moreShow less
Additional material (1)
Abstract
Objective

To test the presence of the obesity paradox in two cohorts of patients hospitalized for COVID-19.

Design

Two multicenter prospective cohorts.

Setting

Three fourth level institutions.

Patients

Adults hospitalized in the general ward for confirmed COVID-19 in the three institutions and those admitted to one of the 9 critical care units of one of the institutions.

Interventions

None.

Main variables of interest

Categorized weight and its relationship with admission to the ICU in hospitalized patients and death in the ICU.

Result

Of 402 hospitalized patients, 30.1% were obese. Of these, 36.1% were admitted to the ICU vs. 27.1% of non-obese patients. Of the 302 ICU patients, 46.4% were obese. Of these, mortality was 45.0% vs. 52.5% for non-obese. The requirement to transfer hospitalized patients to the ICU admission get a HR of 1.47 (95%CI 0.87–2.51, p = 0.154) in the multivariate analysis. In intensive care patients, an HR of 0.99 (95%CI: 0.92–1.07, p = 0.806) was obtained to the association of obesity with mortality.

Conclusions

The present study does not demonstrate an association between obesity and risk of inpatient transfer to intensive care or death of intensive care patients due to COVID-19 therefore, the presence of an obesity paradox is not confirmed.

Keywords:
COVID-19
Prognosis
Death
Intensive care
Resumen
Objetivo

Comprobar la presencia la paradoja de la obesidad en dos cohortes de pacientes hospitalizados por COVID-19.

Diseño

Dos cohortes prospectivas multicéntricas.

Ámbito

Tres instituciones de cuarto nivel.

Pacientes

Adultos hospitalizados en pabellón general por COVID-19 confirmado en las tres instituciones y aquellos internados en alguna de las 9 unidades de cuidado crítico de una de las instituciones.

Intervenciones

Ninguna.

Variables de interés principales

El peso categorizado y su relación con el ingreso a UCI en hospitalizados y de muerte en UCI.

Resultado

Entre 402 hospitalizados 30.1% fueron obesos, de los que 36.1% ingresaron a UCI vs. 27.1% en los no obesos. De los 302 pacientes en UCI, el 46.4% fueron obesos, entre ellos la mortalidad fue de 45.0% vs. 52.5% en los no obesos. En hospitalizados el análisis multivariado obtuvo HR de 1.47 (IC95% 0.87–2.51, p = 0.154) para traslado a UCI. En UCI se obtuvo un OR de 0.99 (IC95%: 0.92–1.07, p = 0.806) para la muerte.

Conclusiones

El presente estudio no demuestran una asociación entre la obesidad y el riesgo de traslados a cuidados intensivos en pacientes hospitalizados ni con la muerte en pacientes en cuidados intensivos por COVID-19 por lo que no se confirma la presencia de una paradoja de la obesidad.

Palabras clave:
COVID-19
Pronóstico
Muerte
Cuidados intensivos

Article

These are the options to access the full texts of the publication Medicina Intensiva (English Edition)
Member
If you are a member of the Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias::
Go to the members area of the website of the SEMICYUC (www.semicyuc.org )and click the link to the magazine.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Medicina Intensiva (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Medicina Intensiva (English Edition)
Article options
Tools
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?