array:24 [
  "pii" => "S2173572722002788"
  "issn" => "21735727"
  "doi" => "10.1016/j.medine.2022.05.013"
  "estado" => "S300"
  "fechaPublicacion" => "2022-12-01"
  "aid" => "1797"
  "copyright" => "Elsevier España, S.L.U. and SEMICYUC"
  "copyrightAnyo" => "2022"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Med Intensiva. 2022;46:724-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210569122001577"
      "issn" => "02105691"
      "doi" => "10.1016/j.medin.2022.05.004"
      "estado" => "S300"
      "fechaPublicacion" => "2022-12-01"
      "aid" => "1797"
      "copyright" => "Elsevier España, S.L.U. y SEMICYUC"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Med Intensiva. 2022;46:724-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">CARTA AL EDITOR</span>"
        "titulo" => "La personalizaci&#243;n de la ventilaci&#243;n mec&#225;nica&#58; s&#237;&#44; pero&#8230; mantengamos la calma"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "724"
            "paginaFinal" => "725"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "The customization of mechanical ventilation&#58; Yes&#44; but&#46;&#46;&#46; Keep calm"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Gonz&#225;lez-Castro, V&#46; Modesto, A&#46; Medina"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Gonz&#225;lez-Castro"
              ]
              1 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Modesto"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Medina"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173572722002788"
          "doi" => "10.1016/j.medine.2022.05.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572722002788?idApp=WMIE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569122001577?idApp=WMIE"
      "url" => "/02105691/0000004600000012/v1_202211260632/S0210569122001577/v1_202211260632/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173572722001874"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2022.07.010"
    "estado" => "S300"
    "fechaPublicacion" => "2022-12-01"
    "aid" => "1566"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Med Intensiva. 2022;46:726-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Intensive Medicine</span>"
      "titulo" => "Cardiac resynchronization therapy rapid reponse in a dilated cardiomyopathy due to Chagas disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "726"
          "paginaFinal" => "727"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Respuesta ecocardiogr&#225;fica y cl&#237;nica precoz a la resincronizaci&#243;n cardiaca en paciente con miocardiopat&#237;a dilatada secundaria a enfermedad de Chagas"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1636
              "Ancho" => 1633
              "Tamanyo" => 225521
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Navarro Mart&#237;nez, I&#46; Keituqwa Y&#225;&#241;ez, S&#46; Nicol&#225;s Franco"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Navarro Mart&#237;nez"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Keituqwa Y&#225;&#241;ez"
            ]
            2 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Nicol&#225;s Franco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021056912030259X"
        "doi" => "10.1016/j.medin.2020.07.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021056912030259X?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572722001874?idApp=WMIE"
    "url" => "/21735727/0000004600000012/v1_202211260614/S2173572722001874/v1_202211260614/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173572722002776"
    "issn" => "21735727"
    "doi" => "10.1016/j.medine.2022.04.017"
    "estado" => "S300"
    "fechaPublicacion" => "2022-12-01"
    "aid" => "1794"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and SEMICYUC"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Intensiva. 2022;46:722-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>"
      "titulo" => "What is the pressure to follow&#63;&#58; Driving pressure versus Tidal pressure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "722"
          "paginaFinal" => "723"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#191;Cu&#225;l es la presi&#243;n a seguir&#63;&#58; <span class="elsevierStyleItalic">Driving pressure</span> frente a <span class="elsevierStyleItalic">Tidal pressure</span>"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 926
              "Ancho" => 2507
              "Tamanyo" => 233733
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pearson correlation coefficient &#40;<span class="elsevierStyleBold">1 A</span>&#41;&#44; and Bland-Altman analysis &#40;<span class="elsevierStyleBold">1 B</span>&#41; comparing driving pressure and tidal pressure&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">DP&#44; driving pressure&#59; TP&#44; tidal pressure&#59; <span class="elsevierStyleBold">1 A&#58;</span> Pearson r<span class="elsevierStyleSup">2</span>&#8239;&#61;&#8239;0&#44;44&#59; IC 95&#37;&#44; 0&#46;31&#8211;0&#46;55&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;0001&#46; <span class="elsevierStyleBold">1 B&#58;</span> 0&#46;02&#8239;cmH<span class="elsevierStyleInf">2</span>O overestimation with 95&#37; confidence intervals from &#8722;0&#46;58 to 0&#46;63&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Gonz&#225;lez-Castro, V&#46; Modesto i Alapont, A&#46; Fernandez, A&#46; Medina Villanueva, E&#46; Cuenca Fito, Y&#46; Pe&#241;asco"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Gonz&#225;lez-Castro"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Modesto i Alapont"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Fernandez"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Medina Villanueva"
            ]
            4 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Cuenca Fito"
            ]
            5 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Pe&#241;asco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210569122001498"
        "doi" => "10.1016/j.medin.2022.04.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210569122001498?idApp=WMIE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572722002776?idApp=WMIE"
    "url" => "/21735727/0000004600000012/v1_202211260614/S2173572722002776/v1_202211260614/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "The customization of mechanical ventilation&#58; Yes&#44; but&#8230; Keep calm"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "724"
        "paginaFinal" => "725"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Gonz&#225;lez-Castro, V&#46; Modesto, A&#46; Medina"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Gonz&#225;lez-Castro"
            "email" => array:1 [
              0 => "e409@humv.es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "V&#46;"
            "apellidos" => "Modesto"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Medina"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Intensiva&#44; Hospital Universitario Marqu&#233;s de Valdecilla&#44; Santander&#44; Cantabria&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Grupo Internacional de Ventilaci&#243;n Mec&#225;nica&#44; WeVent&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "PICU&#44; Hospital Universitario La Fe&#44; Valencia&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "PICU&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "La personalizaci&#243;n de la ventilaci&#243;n mec&#225;nica&#58; s&#237;&#44; pero&#8230; mantengamos la calma"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Individualizing mechanical ventilation &#40;MV&#41; based on physiology and lung morphology&#44; etiology&#44; pulmonary images&#44; and phenotypes should be understood as the titration of ventilation parameters based on close monitoring of specific physiological variables and individual objectives&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">However&#44; individualizing mechanical ventilation parameters&#44; and the speed at which ventilator variables are changed can have important biological effects&#46; This is due to the viscoelastic nature of lung tissue where extracellular matrix components like epithelial&#47;endothelial cells require adaptation time &#40;&#171;stress relaxation&#187;&#41; to alleviate the tension &#40;stress&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Under controlled mechanical ventilation &#40;CMV&#41;&#44; the ventilator needs to exceed elastic and resistive forces to trigger respiratory movement&#46; Whichever the model used to explain lung deformation phenomena &#40;strain&#41;&#44; time must be taken into consideration in such a way that it should explain why alveoli don&#8217;t close immediately or instantaneously fill up with air&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this sense&#44; strain rate is referred to as the speed at which a material expands or contracts&#46; Strain rate is inversely associated with time&#58; with the same tension&#44; the longest times &#40;slow changes to the ventilator variables&#41; are associated with lower strain rates&#46; The shortest times&#44; however&#44; &#40;quick changes to the ventilator variables&#41; are associated with higher strain rates&#46; Therefore&#44; quick changes will end up fracturing interstitial alveolar structures following rapid displacement with poor accommodation to static or dynamic efforts&#46; If these changes occur over time&#44; more fractures of alveolar structures will happen as well&#46; However&#44; slow changes preserve interstitial alveolar structure thanks to a greater accommodation to deformation &#40;strain&#41;&#46; In time&#44; and although alveoli may be heterogeneous&#44; fractures of alveolar structures will be less likely&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Therefore&#44; sudden changes to any ventilation parameters whether static or dynamic &#40;changes to tidal volume&#44; positive end-expiratory pressure &#91;PEEP&#93;&#44; and inspiratory and expiratory flows&#41; capable of changing deformation &#40;strain&#41; over time&#44; can make ventilation-induced damage worse&#46; This premise turns mechanical power into a particularly appealing variable for the management of ventilation parameters since with the basic equation of movement it includes all potential causes of ventilator-induced lung lesion&#58; tidal volume&#44; conduction pressure&#44; flow&#44; respiratory rate&#44; and PEEP&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> As a matter of fact&#44; mechanical power keeps a significant correlation with mortality despite adapting to conduction pressure&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> This proves that mechanical power provides an additional risk estimate beyond conduction pressure <span class="elsevierStyleItalic">per se</span> because it captures the energy applied in a different way compared to conduction pressure&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">However&#44; despite the repercussions this can have in the routine clinical practice<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> maybe little attention is being paid to expiratory phase during CMV&#46; The active control of expiratory phase &#40;in modes of flow-controlled ventilation&#41;&#8212;providing constant and active gas flow during the entire respiratory cycle whether in inspiration or expiration&#8212;minimizes dissipated energy to the lowest possible level&#44; improves lung ventilation in dependent lung regions and&#44; consequently&#44; gas exchange&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0035" class="elsevierStylePara elsevierViewall">This manuscript has not received any funding&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">None reported&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Funding"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Conflicts of interest"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Personalized mechanical ventilation in acute respiratory distress syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Pelosi"
                            1 => "L&#46; Ball"
                            2 => "C&#46;S&#46;V&#46; Barbas"
                            3 => "R&#46; Bellomo"
                            4 => "K&#46;E&#46;A&#46; Burns"
                            5 => "S&#46; Einav"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s13054-021-03686-3"
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Care&#46;"
                        "fecha" => "2021"
                        "volumen" => "25"
                        "paginaInicial" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34271958"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Personalized Mechanical Ventilation Settings&#58; Slower Is Better&#33;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;L&#46; Silva"
                            1 => "P&#46;R&#46;M&#46; Rocco"
                            2 => "P&#46; Pelosi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/978-3-030-93433-0_9"
                      "LibroEditado" => array:5 [
                        "editores" => "J&#46;L&#46;Vincent"
                        "titulo" => "Annual Update in Intensive Care and Emergency Medicine 2022&#46; Annual Update in Intensive Care and Emergency Medicine"
                        "paginaInicial" => "113"
                        "paginaFinal" => "128"
                        "serieFecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stress&#44; strain and mechanical power&#58; is material science the answer to prevent ventilator induced lung injury&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Modesto"
                            1 => "V&#46; Alapont"
                            2 => "M&#46; Aguar Carrascosa"
                            3 => "A&#46; Medina Villanueva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medin.2018.06.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva&#46;"
                        "fecha" => "2019"
                        "volumen" => "43"
                        "paginaInicial" => "165"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30409677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilator-related causes of lung injury&#58; the mechanical power"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Gattinoni"
                            1 => "T&#46; Tonetti"
                            2 => "M&#46; Cressoni"
                            3 => "P&#46; Cadringher"
                            4 => "P&#46; Herrmann"
                            5 => "O&#46; Moerer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-016-4505-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med&#46;"
                        "fecha" => "2016"
                        "volumen" => "42"
                        "paginaInicial" => "1567"
                        "paginaFinal" => "1575"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27620287"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanical power and driving pressure as predictors of mortality among patients with ARDS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;E&#46; Tonna"
                            1 => "I&#46; Peltan"
                            2 => "S&#46;M&#46; Brown"
                            3 => "J&#46;S&#46; Herrick"
                            4 => "H&#46;T&#46; Keenan"
                            5 => "University of Utah Mechanical Power Study Group"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-020-06130-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med&#46;"
                        "fecha" => "2020"
                        "volumen" => "46"
                        "paginaInicial" => "1941"
                        "paginaFinal" => "1943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32504104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inspiratory and expiratory pause during pressure support ventilation&#58; maneuvers that we should incorporate into clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Pavez"
                            1 => "L&#46;F&#46; Damiani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medine.2022.02.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2022"
                        "volumen" => "46"
                        "paginaInicial" => "213"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35210174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudo reverse trigger with double-cycling due to active expiration during pressure support ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Ben&#237;tez Lozano"
                            1 => "J&#46;M&#46; Serrano Sim&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medine.2022.02.011"
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Intensiva"
                        "fecha" => "2022"
                        "volumen" => "2"
                        "paginaInicial" => "4288"
                        "paginaFinal" => "4946"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minimisation of dissipated energy in the airways during mechanical ventilation by using constant inspiratory and expiratory flows - Flow-controlled ventilation &#40;FCV&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Barnes"
                            1 => "D&#46; van Asseldonk"
                            2 => "D&#46; Enk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mehy.2018.09.038"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Hypotheses&#46;"
                        "fecha" => "2018"
                        "volumen" => "121"
                        "paginaInicial" => "167"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30396474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Flow-controlled ventilation attenuates lung injury in a porcine model of acute respiratory distress syndrome&#58; a preclinical randomized controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Schmidt"
                            1 => "C&#46; Wenzel"
                            2 => "S&#46; Spassov"
                            3 => "S&#46; Borgmann"
                            4 => "Z&#46; Lin"
                            5 => "J&#46; Wollborn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0000000000004209"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med&#46;"
                        "fecha" => "2020"
                        "volumen" => "48"
                        "paginaInicial" => "e241"
                        "paginaFinal" => "e248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31856000"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735727/0000004600000012/v1_202211260614/S2173572722002788/v1_202211260614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "64268"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letter to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735727/0000004600000012/v1_202211260614/S2173572722002788/v1_202211260614/en/main.pdf?idApp=WMIE&text.app=https://medintensiva.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173572722002788?idApp=WMIE"
]
Share
Journal Information
Vol. 46. Issue 12.
Pages 724-725 (December 2022)
Vol. 46. Issue 12.
Pages 724-725 (December 2022)
Letter to the Editor
Full text access
The customization of mechanical ventilation: Yes, but… Keep calm
La personalización de la ventilación mecánica: sí, pero… mantengamos la calma
Visits
1599
A. González-Castroa,b,
Corresponding author
e409@humv.es

Corresponding author.
, V. Modestob,c, A. Medinab,d
a Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
b Grupo Internacional de Ventilación Mecánica, WeVent, Spain
c PICU, Hospital Universitario La Fe, Valencia, Spain
d PICU, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
Dear Editor,

Individualizing mechanical ventilation (MV) based on physiology and lung morphology, etiology, pulmonary images, and phenotypes should be understood as the titration of ventilation parameters based on close monitoring of specific physiological variables and individual objectives.1

However, individualizing mechanical ventilation parameters, and the speed at which ventilator variables are changed can have important biological effects. This is due to the viscoelastic nature of lung tissue where extracellular matrix components like epithelial/endothelial cells require adaptation time («stress relaxation») to alleviate the tension (stress).2

Under controlled mechanical ventilation (CMV), the ventilator needs to exceed elastic and resistive forces to trigger respiratory movement. Whichever the model used to explain lung deformation phenomena (strain), time must be taken into consideration in such a way that it should explain why alveoli don’t close immediately or instantaneously fill up with air.1,3

In this sense, strain rate is referred to as the speed at which a material expands or contracts. Strain rate is inversely associated with time: with the same tension, the longest times (slow changes to the ventilator variables) are associated with lower strain rates. The shortest times, however, (quick changes to the ventilator variables) are associated with higher strain rates. Therefore, quick changes will end up fracturing interstitial alveolar structures following rapid displacement with poor accommodation to static or dynamic efforts. If these changes occur over time, more fractures of alveolar structures will happen as well. However, slow changes preserve interstitial alveolar structure thanks to a greater accommodation to deformation (strain). In time, and although alveoli may be heterogeneous, fractures of alveolar structures will be less likely.1,2

Therefore, sudden changes to any ventilation parameters whether static or dynamic (changes to tidal volume, positive end-expiratory pressure [PEEP], and inspiratory and expiratory flows) capable of changing deformation (strain) over time, can make ventilation-induced damage worse. This premise turns mechanical power into a particularly appealing variable for the management of ventilation parameters since with the basic equation of movement it includes all potential causes of ventilator-induced lung lesion: tidal volume, conduction pressure, flow, respiratory rate, and PEEP.4 As a matter of fact, mechanical power keeps a significant correlation with mortality despite adapting to conduction pressure.5 This proves that mechanical power provides an additional risk estimate beyond conduction pressure per se because it captures the energy applied in a different way compared to conduction pressure.

However, despite the repercussions this can have in the routine clinical practice6,7 maybe little attention is being paid to expiratory phase during CMV. The active control of expiratory phase (in modes of flow-controlled ventilation)—providing constant and active gas flow during the entire respiratory cycle whether in inspiration or expiration—minimizes dissipated energy to the lowest possible level, improves lung ventilation in dependent lung regions and, consequently, gas exchange.8,9

Funding

This manuscript has not received any funding.

Conflicts of interest

None reported.

References
[1]
P. Pelosi, L. Ball, C.S.V. Barbas, R. Bellomo, K.E.A. Burns, S. Einav, et al.
Personalized mechanical ventilation in acute respiratory distress syndrome.
Crit Care., 25 (2021), pp. 250
[2]
P.L. Silva, P.R.M. Rocco, P. Pelosi.
Personalized Mechanical Ventilation Settings: Slower Is Better!.
Annual Update in Intensive Care and Emergency Medicine 2022. Annual Update in Intensive Care and Emergency Medicine, pp. 113-128 http://dx.doi.org/10.1007/978-3-030-93433-0_9
[3]
I. Modesto, V. Alapont, M. Aguar Carrascosa, A. Medina Villanueva.
Stress, strain and mechanical power: is material science the answer to prevent ventilator induced lung injury?.
Med Intensiva., 43 (2019), pp. 165-175
[4]
L. Gattinoni, T. Tonetti, M. Cressoni, P. Cadringher, P. Herrmann, O. Moerer, et al.
Ventilator-related causes of lung injury: the mechanical power.
Intensive Care Med., 42 (2016), pp. 1567-1575
[5]
J.E. Tonna, I. Peltan, S.M. Brown, J.S. Herrick, H.T. Keenan, University of Utah Mechanical Power Study Group.
Mechanical power and driving pressure as predictors of mortality among patients with ARDS.
Intensive Care Med., 46 (2020), pp. 1941-1943
[6]
N. Pavez, L.F. Damiani.
Inspiratory and expiratory pause during pressure support ventilation: maneuvers that we should incorporate into clinical practice.
Med Intensiva, 46 (2022), pp. 213-216
[7]
J.A. Benítez Lozano, J.M. Serrano Simón.
Pseudo reverse trigger with double-cycling due to active expiration during pressure support ventilation.
Med Intensiva, 2 (2022), pp. 4288-4946
[8]
T. Barnes, D. van Asseldonk, D. Enk.
Minimisation of dissipated energy in the airways during mechanical ventilation by using constant inspiratory and expiratory flows - Flow-controlled ventilation (FCV).
Med Hypotheses., 121 (2018), pp. 167-176
[9]
J. Schmidt, C. Wenzel, S. Spassov, S. Borgmann, Z. Lin, J. Wollborn, et al.
Flow-controlled ventilation attenuates lung injury in a porcine model of acute respiratory distress syndrome: a preclinical randomized controlled study.
Crit Care Med., 48 (2020), pp. e241-e248
Copyright © 2022. Elsevier España, S.L.U. and SEMICYUC
Idiomas
Medicina Intensiva (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?